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SYNJ2 [cytosol]
Stable Identifier
R-HSA-1806193
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
KIAA0348
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Homo sapiens)
MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2 [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)
SYNJ/INPP5(1) [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Homo sapiens)
MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2 [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15056 SYNJ2
Gene Names
SYNJ2, KIAA0348
Chain
chain:1-1496
Reference Genes
BioGPS Gene:8871 SYNJ2
COSMIC (genes):SYNJ2 SYNJ2
CTD Gene:8871 SYNJ2
dbSNP Gene:8871 SYNJ2
ENSEMBL:ENSG00000078269 SYNJ2
HGNC:11504 SYNJ2
KEGG:hsa:8871 SYNJ2
Monarch:8871 SYNJ2
NCBI Gene:8871 SYNJ2
OMIM:609410 SYNJ2
UCSC:O15056 SYNJ2
Reference Transcript
RefSeq:NM_003898.3 SYNJ2
RefSeq:XM_011536225.1 SYNJ2
RefSeq:NM_001178088.1 SYNJ2
RefSeq:XM_006715592.3 SYNJ2
Other Identifiers
11734961_a_at
11750260_a_at
11750857_a_at
11754394_a_at
1555009_PM_a_at
1555009_a_at
17014114
210612_PM_s_at
210612_s_at
212828_PM_at
212828_at
216180_PM_s_at
216180_s_at
216181_PM_at
216181_at
240257_at
2933393
2933394
2933395
2933396
2933404
2933405
2933406
2933407
2933408
2933413
2933414
2933415
2933416
2933417
2933420
2933421
2933422
2933423
2933436
2933441
2933445
2933446
2933447
2933450
2933451
2933453
2933454
2933455
2933459
2933460
2933463
2933464
2933465
2933467
2933468
2933472
2933473
2933476
2933477
2933478
2933479
2933480
2933481
2933483
2933484
2933485
2933486
2933487
2933491
2933492
2933495
2933498
2933499
2933501
2933502
2933503
2933505
2933506
2933507
2933508
2933509
2933510
36532_at
57630_at
70556_at
8123006
8871
A_14_P125709
A_23_P316974
A_23_P344719
A_24_P294821
A_33_P3354990
GE56813
GO:0003676
GO:0003723
GO:0003824
GO:0004438
GO:0004439
GO:0005515
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006629
GO:0006661
GO:0016192
GO:0016787
GO:0016791
GO:0017124
GO:0019637
GO:0034596
GO:0036092
GO:0042995
GO:0043226
GO:0043813
GO:0045121
GO:0045202
GO:0046856
GO:0048471
GO:0048488
GO:0052629
GO:0052866
GO:0061024
GO:0098793
HMNXSV003001608
HMNXSV003012097
HMNXSV003023119
Hs.207911.0.A1_3p_at
Hs.306877.0.S1_3p_at
Hs.61289.1.S2_3p_at
Hs2.61289.2.A1_3p_s_at
ILMN_2215119
PH_hs_0035978
TC06001128.hg
g12034891_3p_a_at
p33826
Participates
as a member of
SYNJs,OCRL [cytosol] (Homo sapiens)
MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2 [cytosol] (Homo sapiens)
SYNJ/INPP5(1) [cytosol] (Homo sapiens)
Inferred To
INP51 [cytosol]
(Saccharomyces cerevisiae)
Homologues of SYNJ2 [cytosol]
(Saccharomyces cerevisiae)
Homologues of SYNJ2 [cytosol]
(Schizosaccharomyces pombe)
SYNJ2 [cytosol]
(Bos taurus)
SYNJ2 [cytosol]
(Canis familiaris)
SYNJ2 [cytosol]
(Gallus gallus)
SYNJ2 [cytosol]
(Plasmodium falciparum)
SYNJ2 [cytosol]
(Sus scrofa)
Synj [cytosol]
(Drosophila melanogaster)
syj2 [cytosol]
(Schizosaccharomyces pombe)
Synj2 [cytosol]
(Mus musculus)
Synj2 [cytosol]
(Rattus norvegicus)
INP52 [cytosol]
(Saccharomyces cerevisiae)
syj1 [cytosol]
(Schizosaccharomyces pombe)
Dd5P3 [cytosol]
(Dictyostelium discoideum)
INP53 [cytosol]
(Saccharomyces cerevisiae)
unc-26 [cytosol]
(Caenorhabditis elegans)
synj2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011534527.1
,
NP_003889.1
,
XP_006715655.1
,
NP_001171559.1
Guide to Pharmacology - Targets
1462
ENSEMBL
ENSP00000347792
,
ENST00000640338
,
ENSP00000492532
,
ENST00000355585
OpenTargets
ENSG00000078269
HPA
ENSG00000078269-SYNJ2
PRO
O15056
Pharos - Targets
O15056
GlyGen
O15056
HMDB Protein
HMDBP01571
PDB
1UFW
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.669
6
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.573
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.536
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.483
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.483
2
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