Reactome | VAC14 [early endosome membrane]

VAC14 [early endosome membrane]

Stable Identifier

R-HSA-1806207

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome membrane

Synonyms

Protein VAC14 homolog, VAC14_HUMAN, ArPIKfyve, TAX1BP2, TRX

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q08AM6 VAC14

Gene Names

VAC14, TAX1BP2, TRX

Chain

chain:1-782

Reference Genes

BioGPS Gene:55697 VAC14

COSMIC (genes):VAC14 VAC14

CTD Gene:55697 VAC14

dbSNP Gene:55697 VAC14

ENSEMBL:ENSG00000103043 VAC14

ENSEMBL_homo_sapiens_GENE:ENSG00000103043.15 VAC14

HGNC:25507 VAC14

KEGG Gene (Homo sapiens):55697 VAC14

Monarch:55697 VAC14

NCBI Gene:55697 VAC14

OMIM:604632 VAC14

UCSC:Q08AM6 VAC14

Reference Transcript

RefSeq:NM_018052.3 VAC14

Other Identifiers

11719751_a_at

11719752_x_at

11750690_a_at

16827850

218169_PM_at

218169_at

3697219

3697220

3697226

3697227

3697231

3697233

3697234

3697235

3697236

3697261

3697266

3697275

3697276

3697277

3697283

3697284

3697294

3697295

3697296

3697297

3697298

3697299

3697300

3697301

3697302

3697311

3697312

55697

64468_at

8002421

A_23_P77590

GE55709

GE86666

GE86794

GO:0000139

GO:0005515

GO:0005768

GO:0005773

GO:0005783

GO:0005794

GO:0005829

GO:0006629

GO:0006661

GO:0007165

GO:0010008

GO:0016020

GO:0016192

GO:0023052

GO:0031410

GO:0031901

GO:0031902

GO:0038023

GO:0042802

GO:0043226

GO:0043231

GO:0060089

GO:0070772

GO:0098830

GO:0099149

HMNXSV003013007

HMNXSV003013912

ILMN_1750792

ILMN_1776092

ILMN_1799024

PH_hs_0026022

TC16001240.hg

g8922339_3p_at

g8922339_3p_x_at

Participates

as a component of

Other forms of this molecule

VAC14 [Golgi membrane]

VAC14 [late endosome membrane]

Inferred To

Vac14 [early endosome membrane] (Mus musculus)

Vac14 [early endosome membrane] (Rattus norvegicus)

VAC14 [early endosome membrane] (Bos taurus)

VAC14 [early endosome membrane] (Canis familiaris)

VAC14 [early endosome membrane] (Gallus gallus)

VAC14 [early endosome membrane] (Sus scrofa)

Cross References

RefSeq

NP_060522.3

OpenTargets

ENSG00000103043

GeneCards

Q08AM6

HPA

ENSG00000103043-VAC14

Ensembl

ENSG00000103043, ENSP00000261776, ENSP00000439284, ENST00000261776, ENST00000536184

PRO

Q08AM6

Pharos - Targets

Q08AM6

Orphanet

25848

PDB

7K1Y

HMDB Protein

HMDBP14042

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRX5 GINS3	1	GINS3 [nucleoplasm] (R-HSA-5688046)	0.718	6
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.718	6
UniProt:Q9NUB1 ACSS1	1	ACSS1 [mitochondrial matrix] (R-HSA-449914)	0.718	6
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) TP53BP1 [nucleoplasm] (R-HSA-61175)	0.718	6
UniProt:Q9NNX6 CD209	1	CD209 [plasma membrane] (R-HSA-2079928)	0.666	4
UniProt:Q53HV7 SMUG1	1	SMUG1 [nucleoplasm] (R-HSA-110161)	0.666	4
UniProt:P29466 CASP1	5	CASP1(1-119) [cytosol] (R-HSA-448680) CASP1(120-297) [cytosol] (R-HSA-448686) CASP1(317-404) [cytosol] (R-HSA-448704) CASP1(298-316) [cytosol] (R-HSA-448674) CASP1(1-404) [cytosol] (R-HSA-448692)	0.666	4
UniProt:P29475 NOS1	1	NOS1 [cytosol] (R-HSA-419293)	0.618	5
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.556	3
UniProt:O14561 NDUFAB1	4	Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8934586) PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8933545) octanoyl-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-9857608) NDUFAB1 [mitochondrial inner membrane] (R-HSA-163925)	0.556	3
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P35680 HNF1B	1	HNF1B [nucleoplasm] (R-HSA-3004721)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [platelet alpha granule membrane] (R-HSA-61489) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772)	0.556	3
UniProt:Q96QG7 MTMR9	1	MTMR9 [cytosol] (R-HSA-6809239)	0.556	3
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.556	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.527	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.488	2

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