Conversion of Ran-GDP to Ran-GTP

Stable Identifier
R-HSA-180687
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Conversion of Ran-GDP to Ran-GTP
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Free, nuclear RanGTP is required for export processes out of the nucleus. RCC1 catalyses the conversion of Ran-GDP to Ran-GTP in the nucleus.
Literature References
PubMed ID Title Journal Year
7878053 Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport

Bischoff, FR, Krebber, H, Kempf, T, Hermes, I, Ponstingl, H

Proc Natl Acad Sci U S A 1995
1944575 Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

Bischoff, FR, Ponstingl, H

Nature 1991
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of RCC1 [nucleoplasm]

Physical Entity
RCC1 [nucleoplasm] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Authored
Matthews, L  (2006-06-08)
Reviewed
Kumar, A  (2007-02-01)
Created
Matthews, L  (2006-06-02)
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