Reactome | Disassembly of the Rev-importin beta-B23:Ran-GTP complex

Disassembly of the Rev-importin beta-B23:Ran-GTP complex

Stable Identifier

R-HSA-180736

Type

Reaction [dissociation]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - Host Interactions of HIV factors (Homo sapiens)
        
        Interactions of Rev with host cellular proteins (Homo sapiens)
        
        Nuclear import of Rev protein (Homo sapiens)
        
        Disassembly of the Rev-importin beta-B23:Ran-GTP complex (Homo sapiens)

General

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Disassembly of the Rev-importin beta-B23:Ran-GTP complex

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The association of importin-beta with Ran-GTP causes the disassembly of the Rev-importin ß-B23 complex releasing the Rev in the nucleus.

Literature References

PubMed ID	Title	Journal	Year
9405152	Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta Henderson, BR, Percipalle, P	J Mol Biol	1997

Participants

Input

Rev:importin-beta:B23:Ran-GTP complex [nucleoplasm] (Homo sapiens)

Output

Participates

as an event of

Nuclear import of Rev protein (Homo sapiens)

Orthologous Events

Translocation of Rev:importin-beta:B23 to the nucleus (Homo sapiens)

Disease

Name	Identifier	Synonyms
Human immunodeficiency virus infectious disease	DOID:526	HIV infection

Authored

Matthews, L (2006-06-08)

Reviewed

Kumar, A (2007-02-01)

Created

Matthews, L (2006-06-02)

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