Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HIST3H3 [nucleoplasm]
Stable Identifier
R-HSA-181914
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone H3.4
Locations in the PathwayBrowser for interactor UniProt:Q9UHJ3 SMBT1
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Inhibition of DNA recombination at telomere (Homo sapiens)
Histone H3.3 deposition at telomere (Homo sapiens)
HIST3H3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16695 H3-4
Gene Names
H3-4, H3FT, HIST3H3
Chain
initiator methionine:, chain:2-136
Reference Genes
BioGPS Gene:8290 H3-4
COSMIC (genes):HIST3H3 H3-4
CTD Gene:8290 H3-4
dbSNP Gene:8290 H3-4
ENSEMBL:ENSG00000168148 HIST3H3
HGNC:4778 H3-4
KEGG:hsa:8290 H3-4
Monarch:8290 H3-4
NCBI Gene:8290 H3-4
OMIM:602820 H3-4
UCSC:Q16695 H3-4
Reference Transcript
RefSeq:NM_003493.2 H3-4
Other Identifiers
11734595_at
16700233
208572_PM_at
208572_at
2459606
2459607
7924884
8290
ADDON002893.hg
A_23_P137909
GE568338
GO:0000781
GO:0000786
GO:0003677
GO:0005198
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006334
GO:0030527
GO:0043226
GO:0043229
GO:0046982
GO:0065003
GO:0070062
HMNXSV003053825
ILMN_1707173
PH_hs_0029513
TC01003915.hg
g4504298_3p_at
Participates
as an output of
Histone H3.3 deposition at telomere (Homo sapiens)
as a component of
Acetyl H4- Nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome [nucleoplasm] (Homo sapiens)
K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
as a candidate of
Histone H3 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Me2K5-HIST3H3 [nucleoplasm]
Me3K5-HIST3H3 [nucleoplasm]
Inferred To
cnp1 [nucleoplasm]
(Schizosaccharomyces pombe)
H3a [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of HIST3H3 [nucleoplasm]
(Canis familiaris)
Ghost homologue of HIST3H3 [nucleoplasm]
(Danio rerio)
Ghost homologue of HIST3H3 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of HIST3H3 [nucleoplasm]
(Gallus gallus)
Ghost homologue of HIST3H3 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of HIST3H3 [nucleoplasm]
(Sus scrofa)
Ghost homologue of HIST3H3 [nucleoplasm]
(Xenopus tropicalis)
H3f4 [nucleoplasm]
(Mus musculus)
CSE4 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of HIST3H3 [nucleoplasm]
(Plasmodium falciparum)
HIST3H3 [nucleoplasm]
(Bos taurus)
HIST3H3 [nucleoplasm]
(Plasmodium falciparum)
Cross References
RefSeq
NP_003484.1
ENSEMBL
ENSP00000355657
,
ENST00000366696
,
ENSP00000494070
,
ENST00000644869
OpenTargets
ENSG00000168148
HPA
ENSG00000168148-H3-4
PRO
Q16695
Pharos - Targets
Q16695
GlyGen
Q16695
PDB
6WAU
,
6WAT
,
2YBP
,
2YBS
,
6OIE
,
3T6R
,
4V2V
,
3A6N
,
4V2W
,
2V1D
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62805 H4C1
17
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
HIST1H4A [extracellular region]
(R-HSA-977569)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
0.676
3
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.641
12
UniProt:O75164 KDM4A
2
KDM4A [nucleoplasm]
(R-HSA-351646)
K48PolyUb-KDM4A [nucleoplasm]
(R-HSA-5683049)
0.618
6
UniProt:P04908 H2AC4
13
HIST1H2AB [nucleoplasm]
(R-HSA-181888)
Ack-HIST1H2AB [nucleoplasm]
(R-HSA-4551332)
HIST1H2AB [extracellular region]
(R-HSA-977555)
MeR12-HIST1H2AB [nucleoplasm]
(R-HSA-5229221)
Me2aR12-HIST1H2AB [nucleoplasm]
(R-HSA-5229308)
Me2sR4-HIST1H2AB [nucleoplasm]
(R-HSA-5218304)
MeR4-HIST1H2AB [nucleoplasm]
(R-HSA-5244595)
Me2aR4-HIST1H2AB [nucleoplasm]
(R-HSA-5244628)
MeR30-HIST1H2AB [nucleoplasm]
(R-HSA-5244576)
Me2aR30-HIST1H2AB [nucleoplasm]
(R-HSA-5244538)
Ack6-HIST1H2AB [nucleoplasm]
(R-HSA-4568598)
Ub-HIST1H2AB [nucleoplasm]
(R-HSA-6782483)
K63polyUb-HIST1H2AB [nucleoplasm]
(R-HSA-6783287)
0.589
2
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.564
2
UniProt:Q9UHJ3 SMBT1
0.558
4
UniProt:Q0D2K3 RIPP1
0.556
3
UniProt:P49321-2 NASP
0.556
6
UniProt:Q96GD4 AURKB
3
AURKB [cytosol]
(R-HSA-174231)
AURKB [nucleoplasm]
(R-HSA-4655360)
polySUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
0.544
8
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text