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CD4 [early endosome]
Stable Identifier
R-HSA-182147
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
early endosome
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
Nef Mediated CD4 Down-regulation (Homo sapiens)
Degradation of CD4 (Homo sapiens)
Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
CD4 [early endosome] (Homo sapiens)
Formation of a Nef:ARF1:CD4 complex (Homo sapiens)
Arf1:Nef:endosomal CD4 [early endosome membrane] (Homo sapiens)
CD4 [early endosome] (Homo sapiens)
Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
CD4 [early endosome] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01730 CD4
Gene Names
CD4
Chain
signal peptide:1-25, chain:26-458
Reference Genes
BioGPS Gene:920 CD4
COSMIC (genes):CD4 CD4
CTD Gene:920 CD4
dbSNP Gene:920 CD4
ENSEMBL:ENSG00000010610 CD4
HGNC:1678 CD4
KEGG:hsa:920 CD4
Monarch:920 CD4
NCBI Gene:920 CD4
OMIM:186940 CD4
UCSC:P01730 CD4
Reference Transcript
RefSeq:NM_000616.4 CD4
Other Identifiers
1146_at
11738979_x_at
11738980_a_at
11738981_x_at
11738982_at
11750157_at
16747417
203547_PM_at
203547_at
3402787
3402788
3402790
3402791
3402793
3402794
3402795
3402798
3402799
3402800
3402801
3402802
3402803
3402804
3402805
3402807
3402810
3402811
3402812
3402813
3402815
35517_at
48538_at
7953428
920
A_14_P100337
A_14_P109852
A_21_P0000664
A_24_P295999
GE61155
GE84064
GO:0001618
GO:0001934
GO:0002250
GO:0002376
GO:0004888
GO:0005198
GO:0005201
GO:0005515
GO:0005768
GO:0005769
GO:0005788
GO:0005789
GO:0005886
GO:0006355
GO:0006955
GO:0007155
GO:0007165
GO:0007166
GO:0007167
GO:0007169
GO:0008270
GO:0008289
GO:0009897
GO:0009986
GO:0015026
GO:0016020
GO:0019722
GO:0019899
GO:0019901
GO:0023026
GO:0030154
GO:0030217
GO:0030225
GO:0030669
GO:0031410
GO:0032507
GO:0032743
GO:0033674
GO:0035397
GO:0035723
GO:0038023
GO:0042011
GO:0042012
GO:0042101
GO:0042110
GO:0042289
GO:0042802
GO:0042803
GO:0043123
GO:0043226
GO:0043410
GO:0045058
GO:0045121
GO:0045657
GO:0045860
GO:0045893
GO:0046598
GO:0046718
GO:0050731
GO:0050829
GO:0050850
GO:0050863
GO:0050870
GO:0051924
GO:0060089
GO:0070374
GO:0097011
GO:0098542
GO:1990782
HMNXSV003005320
HMNXSV003009618
HMNXSV003037992
Hs.17483.0.S2_3p_at
ILMN_1727284
PH_hs_0001579
PH_hs_0040481
TC12000092.hg
TC12002205.hg
Participates
as a component of
Arf1:Nef:endosomal CD4 [early endosome membrane] (Homo sapiens)
Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
Other forms of this molecule
CD4 [plasma membrane]
CD4 [endoplasmic reticulum membrane]
CD4 [clathrin-coated endocytic vesicle membrane]
Cross References
RefSeq
NP_000607.1
Guide to Pharmacology - Targets
2995
OpenTargets
ENSG00000010610
ENSEMBL
ENSP00000011653
,
ENST00000011653
HPA
ENSG00000010610-CD4
ZINC - Substances
CD4_HUMAN
ZINC target
P01730
PRO
P01730
Pharos - Targets
P01730
GlyGen
P01730
ZINC - Predictions - Purchasable
CD4_HUMAN
PDB
3CD4
,
8FYJ
,
6L1Y
,
3JCB
,
3JWO
,
3JCC
,
6U0L
,
4H8W
,
2NXY
,
2B4C
,
4Q6I
,
5A7X
,
1Q68
,
8D5C
,
1GC1
,
6OPQ
,
6X5C
,
6OPP
,
6OPO
,
6QH6
,
3S5L
,
4P9H
,
2NY0
,
2NY4
,
2NY2
,
6MEO
,
3O2D
,
7T0O
,
2KLU
,
5VN3
,
7TXD
,
1CDI
,
2NY5
,
1CDH
,
2NY6
,
5CAY
,
1WIP
,
1G9N
,
1CDY
,
2QAD
,
5U1F
,
1JL4
,
6X5B
,
3S4S
,
6OPN
,
8FYI
,
2NXZ
,
5THR
,
1WBR
,
4R4H
,
1CDJ
,
3JWD
,
6QH7
,
6CM3
,
3B71
,
3J70
,
5A8H
,
6U0N
,
2JKR
,
4JM2
,
2NY3
,
2NY1
,
6MET
,
3LQA
,
7T0R
,
6URI
,
1RZJ
,
1RZK
,
6EDU
,
3T0E
,
4R2G
,
1WIQ
,
1WIO
,
1G9M
,
4RQS
,
2JKT
,
1CDU
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06239 LCK
4
LCK [cytosol]
(R-HSA-167609)
p-Y394-LCK [cytosol]
(R-HSA-202308)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
0.702
3
UniProt:P51681 CCR5
1
CCR5 [plasma membrane]
(R-HSA-171279)
0.667
3
UniProt:Q2N0S6 Q2N0S6
0.618
3
UniProt:P04578-PRO_0000038427 ENV
0.618
3
UniProt:P04578 env
7
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
0.558
2
UniProt:P03407 NEF
0.558
2
UniProt:P01730 CD4
4
CD4 [plasma membrane]
(R-HSA-167542)
CD4 [endoplasmic reticulum membrane]
(R-HSA-180575)
CD4 [early endosome]
(R-HSA-182147)
CD4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869082)
0.558
2
UniProt:Q1PHM6 Q1PHM6
0.558
2
UniProt:P13473-2 P134732
0.556
3
UniProt:Q9Y371 SHLB1
0.556
3
UniProt:Q9NPF0 CD320
2
CD320 [plasma membrane]
(R-HSA-2980909)
CD320 E88del [plasma membrane]
(R-HSA-3325560)
0.527
2
UniProt:Q9H2C2 ARV1
1
ARV1 [endoplasmic reticulum membrane]
(R-HSA-5216144)
0.527
2
UniProt:Q15836 VAMP3
6
VAMP3 [recycling endosome membrane]
(R-HSA-2029063)
VAMP3 [phagocytic vesicle membrane]
(R-HSA-2029013)
VAMP3 [plasma membrane]
(R-HSA-8867599)
VAMP3 [trans-Golgi network membrane]
(R-HSA-6814624)
VAMP3 [transport vesicle]
(R-HSA-6814625)
VAMP3 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869130)
0.527
2
UniProt:Q9Y487 ATP6V0A2
2
ATP6V0A2 [phagocytic vesicle membrane]
(R-HSA-1222546)
ATP6V0A2 [endosome membrane]
(R-HSA-912595)
0.527
2
UniProt:Q96ER3 SAAL1
0.527
2
UniProt:A6NKD9 CC85C
0.527
2
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.524
3
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