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AP2A2(1-939) [cytosol]
Stable Identifier
R-HSA-182155
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Adaptor protein complex AP-2 alpha-2 subunit
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
Clathrin internalises EPH:EFN complexes (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
Nef Mediated CD4 Down-regulation (Homo sapiens)
Degradation of CD4 (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
CD4:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
CD4:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Nef Mediated CD8 Down-regulation (Homo sapiens)
Degradation of CD8 (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Internalized CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
CD8:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
CD8:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Internalized CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
AP2 binds chlorpromazine (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
AP2:chlorpromazine [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (Homo sapiens)
FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Homo sapiens)
clathrin:AP-2 [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
WNT5A-dependent internalization of FZD4 (Homo sapiens)
WNT5A:FZD4 is endocytosed (Homo sapiens)
WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Homo sapiens)
clathrin:AP-2 [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Homo sapiens)
WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Homo sapiens)
clathrin:AP-2 [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
clathrin:AP-2 [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
AP-2 directly binds some endocytic cargo (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
AP2:chlorpromazine [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
AP2 binds chlorpromazine (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
AP2:chlorpromazine [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Clathrin-coated vesicle [cytosol] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
Recruitment of AP-2 complex and clathrin (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
p-T156 AP-2 Complex [cytosol] (Homo sapiens)
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
AP2A2(1-939) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94973 AP2A2
Gene Names
AP2A2, ADTAB, CLAPA2, HIP9, HYPJ, KIAA0899
Chain
chain:1-939
Reference Genes
BioGPS Gene:161 AP2A2
COSMIC (genes):AP2A2 AP2A2
CTD Gene:161 AP2A2
dbSNP Gene:161 AP2A2
ENSEMBL:ENSG00000183020 AP2A2
ENSEMBL_homo_sapiens_GENE:ENSG00000183020.15 AP2A2
HGNC:562 AP2A2
KEGG Gene (Homo sapiens):161 AP2A2
Monarch:161 AP2A2
NCBI Gene:161 AP2A2
OMIM:607242 AP2A2
UCSC:O94973 AP2A2
Reference Transcript
RefSeq:NM_012305.3 AP2A2
RefSeq:NM_001242837.1 AP2A2
Other Identifiers
11741016_a_at
11741017_s_at
11755014_a_at
161
16720440
211779_PM_x_at
211779_x_at
212159_PM_x_at
212159_x_at
212161_3p_at
212161_PM_at
212161_at
215764_3p_x_at
215764_PM_x_at
215764_x_at
32228_at
3316451
3316452
3316453
3316454
3316455
3316471
3316477
3316481
3316484
3316488
3316492
3316493
3316494
3316502
3316508
3316512
3316514
3316515
3316516
3316520
3316528
3316532
3316540
3316542
3316543
3316544
3316546
3316547
3316548
3316549
3316550
3316551
3316552
3316553
3316554
3316555
3316556
3316557
3316558
3316559
3316560
3316562
7937533
A_14_P126629
A_23_P21853
A_24_P339974
A_24_P932418
A_33_P3311863
GE53571
GO:0003674
GO:0005515
GO:0005764
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0005905
GO:0006886
GO:0006897
GO:0008289
GO:0009898
GO:0015031
GO:0016020
GO:0016192
GO:0019900
GO:0019901
GO:0019904
GO:0030117
GO:0030122
GO:0030131
GO:0030666
GO:0030667
GO:0030669
GO:0031410
GO:0035615
GO:0036020
GO:0043226
GO:0045334
GO:0060090
GO:0072583
GO:0097718
GO:0098794
GO:0098884
GO:0101003
HMNXSV003023222
HMNXSV003045833
Hs.19121.0.S2_3p_a_at
Hs.19121.0.S2_3p_at
Hs.19121.0.S2_3p_x_at
Hs.19121.1.S1_3p_a_at
Hs.19121.1.S1_3p_at
ILMN_1803779
PH_hs_0001684
TC11000036.hg
g13544040_3p_s_at
Participates
as a member of
Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Homo sapiens)
Other forms of this molecule
AP2A2(1-939) [endolysosome membrane]
AP2A2(1-939) [ficolin-1-rich granule membrane]
AP2A2(1-939) [secretory granule membrane]
AP2A2(1-939) [plasma membrane]
AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]
Inferred To
APL3 [cytosol]
(Saccharomyces cerevisiae)
ap2a1-2 [cytosol]
(Dictyostelium discoideum)
apl3 [cytosol]
(Schizosaccharomyces pombe)
AP-2alpha [cytosol]
(Drosophila melanogaster)
AP2A2(1-939) [cytosol]
(Bos taurus)
AP2A2(1-939) [cytosol]
(Caenorhabditis elegans)
AP2A2(1-939) [cytosol]
(Canis familiaris)
AP2A2(1-939) [cytosol]
(Gallus gallus)
AP2A2(1-939) [cytosol]
(Mus musculus)
AP2A2(1-939) [cytosol]
(Plasmodium falciparum)
AP2A2(1-939) [cytosol]
(Rattus norvegicus)
AP2A2(1-939) [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001229766.1
,
NP_036437.1
OpenTargets
ENSG00000183020
HPA
ENSG00000183020-AP2A2
GeneCards
O94973
Ensembl
ENSP00000431630
,
ENSG00000183020
,
ENST00000448903
,
ENSP00000413234
,
ENSP00000327694
,
ENST00000528815
,
ENST00000332231
PRO
O94973
Pharos - Targets
O94973
HMDB Protein
HMDBP14130
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.643
5
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
SHC1 [cytosol]
(R-HSA-74680)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.643
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.569
4
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.527
2
UniProt:P98078
3
Dab2 [cytosol]
(R-MMU-8862456)
Dab2 [lysosomal membrane]
(R-MMU-2980807)
Dab2 [plasma membrane]
(R-MMU-2980808)
0.499
2
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