Degradation of MHC I Complex

Stable Identifier
R-HSA-182263
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
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Degradation of MHC I Complex
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Once the complex of Nef, major histocompatibility complex class I molecules, PACS-1 and AP-1 arrives at the endosome, the MHC I complex is targeted for degradation.

Literature References
PubMed ID Title Journal Year
15569716 HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail

Filzen, TM, Williams, M, Roeth, JF, Collins, KL, Kasper, MR

J Cell Biol 2004
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Gillespie, ME  (2007-07-25)
Reviewed
Skowronski, J  (2007-08-07)
Created
Gillespie, ME  (2006-07-06)
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