Reactome | EPS15 [cytosol]

EPS15 [cytosol]

Stable Identifier

R-HSA-182920

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Eps15

Locations in the PathwayBrowser for interactor UniProt:O95782 AP2A1

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External Reference Information

External Reference

UniProt:P42566 EPS15

Gene Names

EPS15, AF1P

Chain

initiator methionine:, chain:2-896

Reference Genes

COSMIC (genes):EPS15 EPS15

dbSNP Gene:2060 EPS15

ENSEMBL:ENSG00000085832 EPS15

Participates

as an output of

Dissociation of clathrin-associated proteins (Homo sapiens)

as a component of

as an input of

FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)

as a member of

EPS15,EPN1,EPN2 [cytosol] (Homo sapiens)

Other forms of this molecule

p-Y849 EPS15 [cytosol]

Inferred To

EPS15 [cytosol] (Bos taurus)

EPS15 [cytosol] (Canis familiaris)

EPS15 [cytosol] (Gallus gallus)

EPS15 [cytosol] (Mus musculus)

EPS15 [cytosol] (Plasmodium falciparum)

EPS15 [cytosol] (Saccharomyces cerevisiae)

EPS15 [cytosol] (Schizosaccharomyces pombe)

EPS15 [cytosol] (Sus scrofa)

Eps15 [cytosol] (Rattus norvegicus)

Eps-15 [cytosol] (Drosophila melanogaster)

ehs-1 [cytosol] (Caenorhabditis elegans)

eps15 [cytosol] (Dictyostelium discoideum)

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WXE9 STON2	2	NEDD8-STON2 [cytosol] (R-HSA-8863733) STON2 [cytosol] (R-HSA-8862856)	0.84	19
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.75	6
UniProt:P53680 AP2S1	4	AP2S1 [endolysosome membrane] (R-HSA-6784821) AP2S1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130707) AP2S1 [cytosol] (R-HSA-182197) AP2S1 [plasma membrane] (R-HSA-389382)	0.725	6
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.725	7
UniProt:Q9JJ50	1	HGS [cytosol] (R-RNO-182954)	0.72	5
UniProt:Q0JRZ9 FCHO2	1	FCHO2 [cytosol] (R-HSA-8862260)	0.695	4
UniProt:P52594 AGFG1	1	AGFG1 [cytosol] (R-HSA-8863714)	0.656	3
UniProt:P63010 AP2B1	4	AP2B1 [endolysosome membrane] (R-HSA-6784827) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [cytosol] (R-HSA-182166) AP2B1 [plasma membrane] (R-HSA-167690)	0.643	4
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.643	5
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.641	4
UniProt:Q9Y6I3 EPN1	2	EPN1 [cytosol] (R-HSA-8865826) EPN1 [plasma membrane] (R-HSA-182952)	0.623	2
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.609	2
UniProt:Q13492 PICALM	3	PICALM [Golgi membrane] (R-HSA-434341) PICALM [cytoplasmic vesicle membrane] (R-HSA-429812) PICALM [cytosol] (R-HSA-8867593)	0.59	2
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.564	3
UniProt:Q3UQN2	1	Fcho2 [cytosol] (R-MMU-8862260)	0.557	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	5
UniProt:Q9QYW3 PHOCN			0.544	2
UniProt:Q9QZS3-2 NUMB			0.539	3
UniProt:Q9QZS3-1 NUMB			0.539	3
UniProt:P09497 CLTB	5	CLTB [cytosol] (R-HSA-8856819) CLTB [trans-Golgi network membrane] (R-HSA-5333645) CLTB [clathrin-coated endocytic vesicle membrane] (R-HSA-5138428) CLTB [lysosomal membrane] (R-HSA-2980616) CLTB [plasma membrane] (R-HSA-2980617)	0.527	2
UniProt:O95782 AP2A1	5	AP2A1 [endolysosome membrane] (R-HSA-6784829) AP2A1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138449) AP2A1 [cytosol] (R-HSA-182143) AP2A1 [plasma membrane] (R-HSA-177494) AP2A1 [endocytic vesicle membrane] (R-HSA-416641)	0.527	2
UniProt:P55809 OXCT1	1	OXCT1 [mitochondrial matrix] (R-HSA-74317)	0.527	2
UniProt:O94973 AP2A2	6	AP2A2(1-939) [endolysosome membrane] (R-HSA-6784819) AP2A2(1-939) [secretory granule membrane] (R-HSA-6800412) AP2A2(1-939) [ficolin-1-rich granule membrane] (R-HSA-6800414) AP2A2(1-939) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138448) AP2A2(1-939) [cytosol] (R-HSA-182155) AP2A2(1-939) [plasma membrane] (R-HSA-177502)	0.527	2
UniProt:Q96FJ0 STAMBPL1	1	STAMBPL1 [cytosol] (R-HSA-6783264)	0.527	2
UniProt:Q86X29 LSR	1	LSR [plasma membrane] (R-HSA-8933138)	0.527	2
UniProt:Q10567 AP1B1	5	AP1B1 [cytoplasmic vesicle membrane] (R-HSA-351181) AP1B1 [Golgi membrane] (R-HSA-350809) AP1B1 [lysosomal membrane] (R-HSA-432699) AP1B1 [trans-Golgi network membrane] (R-HSA-2130596) AP1B1 [cytosol] (R-HSA-167705)	0.527	2
UniProt:Q9HBM1 SPC25	1	SPC25 [cytosol] (R-HSA-375307)	0.527	4
UniProt:Q8N5S1 S2541			0.527	2
UniProt:P0C7W6 CC172			0.527	2
UniProt:Q9NVZ3 NECAP2	1	NECAP2 [cytosol] (R-HSA-8863466)	0.527	2
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.527	3
UniProt:Q9UBC2 EPS15L1	2	EPS15L1 [plasma membrane] (R-HSA-182937) EPS15L1 [cytosol] (R-HSA-8935900)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P98078-1 DAB2			0.463	2

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