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EPS15 [cytosol]
Stable Identifier
R-HSA-182920
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Eps15
Locations in the PathwayBrowser for interactor UniProt:Q13492 PICALM
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
EPS15 [cytosol] (Homo sapiens)
FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)
EPS15 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42566 EPS15
Gene Names
EPS15, AF1P
Chain
initiator methionine:, chain:2-896
Reference Genes
BioGPS Gene:2060 EPS15
COSMIC (genes):EPS15 EPS15
CTD Gene:2060 EPS15
dbSNP Gene:2060 EPS15
ENSEMBL:ENSG00000085832 EPS15
ENSEMBL_homo_sapiens_GENE:ENSG00000085832.18 EPS15
HGNC:3419 EPS15
KEGG Gene (Homo sapiens):2060 EPS15
Monarch:2060 EPS15
NCBI Gene:2060 EPS15
OMIM:600051 EPS15
UCSC:P42566 EPS15
Reference Transcript
RefSeq:NM_001159969.1 EPS15
RefSeq:NM_001981.2 EPS15
Other Identifiers
11719484_at
11719485_x_at
11719486_s_at
11750789_a_at
11751985_a_at
11756703_a_at
16687028
2060
217886_PM_at
217886_at
217887_PM_s_at
217887_s_at
2412361
2412362
2412363
2412364
2412365
2412368
2412369
2412370
2412371
2412372
2412387
2412389
2412390
2412392
2412394
2412395
2412397
2412398
2412399
2412400
2412401
2412402
2412406
2412408
2412410
2412413
2412418
2412419
2412420
2412422
2412423
2412424
2412428
2412441
2412442
37731_at
78641_at
7916045
A_23_P202
A_24_P28578
A_33_P3322328
GE60385
GO:0001921
GO:0005509
GO:0005515
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0005905
GO:0006895
GO:0006897
GO:0009925
GO:0015031
GO:0016020
GO:0016050
GO:0016192
GO:0016197
GO:0016235
GO:0016324
GO:0017124
GO:0019065
GO:0023052
GO:0030132
GO:0031410
GO:0031593
GO:0031901
GO:0032456
GO:0042127
GO:0043226
GO:0043231
GO:0045202
GO:0045296
GO:0046718
GO:0046872
GO:0048268
GO:0065003
GO:0098794
GO:0098884
GO:0098978
HMNXSV003032069
Hs.79095.0.S2_3p_at
ILMN_1665357
PH_hs_0027703
TC01002649.hg
Z29064_at
g4503592_3p_a_at
Participates
as an output of
Dissociation of clathrin-associated proteins (Homo sapiens)
as a component of
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
EPS15:HGS:STAM [cytosol] (Homo sapiens)
as an input of
FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)
as a member of
EPS15,EPN1,EPN2 [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y849 EPS15 [cytosol]
Inferred To
EPS15 [cytosol]
(Bos taurus)
EPS15 [cytosol]
(Canis familiaris)
EPS15 [cytosol]
(Gallus gallus)
EPS15 [cytosol]
(Mus musculus)
EPS15 [cytosol]
(Plasmodium falciparum)
EPS15 [cytosol]
(Saccharomyces cerevisiae)
EPS15 [cytosol]
(Schizosaccharomyces pombe)
EPS15 [cytosol]
(Sus scrofa)
Eps15 [cytosol]
(Rattus norvegicus)
Eps-15 [cytosol]
(Drosophila melanogaster)
ehs-1 [cytosol]
(Caenorhabditis elegans)
eps15 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001153441.1
,
NP_001972.1
OpenTargets
ENSG00000085832
HPA
ENSG00000085832-EPS15
GeneCards
P42566
Ensembl
ENSP00000516332
,
ENSG00000085832
,
ENST00000493793
,
ENSP00000360798
,
ENST00000371733
PRO
P42566
Pharos - Targets
P42566
PDB
5JP2
,
1FF1
,
2JXC
,
4RH9
,
1EH2
,
4RHG
,
4RH5
,
1F8H
,
4S0G
,
1C07
,
5AWU
,
5AWT
,
2IV9
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WXE9 STON2
2
NEDD8-STON2 [cytosol]
(R-HSA-8863733)
STON2 [cytosol]
(R-HSA-8862856)
0.84
19
UniProt:P49757 NUMB
1
NUMB [plasma membrane]
(R-HSA-443595)
0.75
6
UniProt:P53680 AP2S1
4
AP2S1 [cytosol]
(R-HSA-182197)
AP2S1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130707)
AP2S1 [plasma membrane]
(R-HSA-389382)
AP2S1 [endolysosome membrane]
(R-HSA-6784821)
0.725
6
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.725
7
UniProt:Q9JJ50
1
HGS [cytosol]
(R-RNO-182954)
0.72
5
UniProt:Q0JRZ9 FCHO2
1
FCHO2 [cytosol]
(R-HSA-8862260)
0.695
4
UniProt:P52594 AGFG1
1
AGFG1 [cytosol]
(R-HSA-8863714)
0.656
3
UniProt:P63010 AP2B1
4
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
AP2B1 [plasma membrane]
(R-HSA-167690)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
0.643
4
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.643
5
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.641
4
UniProt:Q9Y6I3 EPN1
2
EPN1 [plasma membrane]
(R-HSA-182952)
EPN1 [cytosol]
(R-HSA-8865826)
0.623
2
UniProt:Q9P0V3 SH3BP4
1
SH3BP4 [cytosol]
(R-HSA-8866227)
0.609
2
UniProt:Q13492 PICALM
3
PICALM [cytosol]
(R-HSA-8867593)
PICALM [cytoplasmic vesicle membrane]
(R-HSA-429812)
PICALM [Golgi membrane]
(R-HSA-434341)
0.59
2
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.564
3
UniProt:Q3UQN2
1
Fcho2 [cytosol]
(R-MMU-8862260)
0.557
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
5
UniProt:Q9QYW3 PHOCN
0.544
2
UniProt:Q9QZS3-2 NUMB
0.539
3
UniProt:Q9QZS3-1 NUMB
0.539
3
UniProt:P09497 CLTB
5
CLTB [cytosol]
(R-HSA-8856819)
CLTB [trans-Golgi network membrane]
(R-HSA-5333645)
CLTB [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138428)
CLTB [lysosomal membrane]
(R-HSA-2980616)
CLTB [plasma membrane]
(R-HSA-2980617)
0.527
2
UniProt:O95782 AP2A1
5
AP2A1 [endolysosome membrane]
(R-HSA-6784829)
AP2A1 [endocytic vesicle membrane]
(R-HSA-416641)
AP2A1 [plasma membrane]
(R-HSA-177494)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138449)
AP2A1 [cytosol]
(R-HSA-182143)
0.527
2
UniProt:P55809 OXCT1
1
OXCT1 [mitochondrial matrix]
(R-HSA-74317)
0.527
2
UniProt:O94973 AP2A2
6
AP2A2(1-939) [endolysosome membrane]
(R-HSA-6784819)
AP2A2(1-939) [ficolin-1-rich granule membrane]
(R-HSA-6800414)
AP2A2(1-939) [secretory granule membrane]
(R-HSA-6800412)
AP2A2(1-939) [plasma membrane]
(R-HSA-177502)
AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138448)
AP2A2(1-939) [cytosol]
(R-HSA-182155)
0.527
2
UniProt:Q96FJ0 STAMBPL1
1
STAMBPL1 [cytosol]
(R-HSA-6783264)
0.527
2
UniProt:Q86X29 LSR
1
LSR [plasma membrane]
(R-HSA-8933138)
0.527
2
UniProt:Q10567 AP1B1
5
AP1B1 [cytoplasmic vesicle membrane]
(R-HSA-351181)
AP1B1 [Golgi membrane]
(R-HSA-350809)
AP1B1 [lysosomal membrane]
(R-HSA-432699)
AP1B1 [trans-Golgi network membrane]
(R-HSA-2130596)
AP1B1 [cytosol]
(R-HSA-167705)
0.527
2
UniProt:Q9HBM1 SPC25
1
SPC25 [cytosol]
(R-HSA-375307)
0.527
4
UniProt:Q8N5S1 S2541
0.527
2
UniProt:P0C7W6 CC172
0.527
2
UniProt:Q9NVZ3 NECAP2
1
NECAP2 [cytosol]
(R-HSA-8863466)
0.527
2
UniProt:O14965 AURKA
6
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.527
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q9UBC2 EPS15L1
2
EPS15L1 [plasma membrane]
(R-HSA-182937)
EPS15L1 [cytosol]
(R-HSA-8935900)
0.527
3
UniProt:P98078-1 DAB2
0.463
2
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