Reactome | EPS15 [cytosol]

EPS15 [cytosol]

Stable Identifier

R-HSA-182920

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Eps15

Locations in the PathwayBrowser for interactor UniProt:Q13492 PICALM

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 Function (Homo sapiens)
        
        Degradation of CDH1 (Homo sapiens)
        
        The complex of MDM2 and CDH1 translocates to early endosomes (Homo sapiens)
        
        EPS15 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P42566 EPS15

Gene Names

EPS15, AF1P

Chain

initiator methionine:1, chain:2-896

Reference Genes

BioGPS Gene:2060 EPS15

COSMIC (genes):EPS15 EPS15

CTD Gene:2060 EPS15

dbSNP Gene:2060 EPS15

ENSEMBL:ENSG00000085832 EPS15

HGNC:3419 EPS15

KEGG:hsa:2060 EPS15

Monarch:2060 EPS15

NCBI Gene:2060 EPS15

OMIM:600051 EPS15

UCSC:P42566 EPS15

Reference Transcript

Participates

as an output of

Dissociation of clathrin-associated proteins (Homo sapiens)

as a component of

as an input of

FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)

as a member of

EPS15,EPN1,EPN2 [cytosol] (Homo sapiens)

This entity regulates

Positively

The complex of MDM2 and CDH1 translocates to early endosomes (Homo sapiens)

Other forms of this molecule

p-Y849 EPS15 [cytosol]

Inferred To

Homologues of EPS15 [cytosol] (Plasmodium falciparum)

EPS15 [cytosol] (Bos taurus)

EPS15 [cytosol] (Canis familiaris)

EPS15 [cytosol] (Gallus gallus)

EPS15 [cytosol] (Plasmodium falciparum)

EPS15 [cytosol] (Sus scrofa)

Eps15 [cytosol] (Mus musculus)

Eps15 [cytosol] (Rattus norvegicus)

Eps-15 [cytosol] (Drosophila melanogaster)

ehs-1 [cytosol] (Caenorhabditis elegans)

eps15 [cytosol] (Danio rerio)

eps15 [cytosol] (Dictyostelium discoideum)

eps15 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001972.1, NP_001153441.1

OpenTargets

ENSG00000085832

ENSEMBL

ENSP00000360798, ENSG00000085832, ENSP00000516332, ENST00000371733, ENST00000493793

GeneCards

EPS15

HPA

ENSG00000085832-EPS15

PRO

P42566

Pharos - Targets

P42566

GlyGen

P42566

PDB

5AWT, 4S0G, 2JXC, 4RH9, 1FF1, 1F8H, 5AWU, 4RHG, 2IV9, 1C07, 1EH2, 5JP2, 4RH5

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WXE9 STON2	2	NEDD8-STON2 [cytosol] (R-HSA-8863733) STON2 [cytosol] (R-HSA-8862856)	0.84	19
UniProt:P53680 AP2S1	4	AP2S1 [cytosol] (R-HSA-182197) AP2S1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130707) AP2S1 [plasma membrane] (R-HSA-389382) AP2S1 [endolysosome membrane] (R-HSA-6784821)	0.788	7
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.75	6
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.725	7
UniProt:Q9JJ50	1	Hgs [cytosol] (R-RNO-182954)	0.72	5
UniProt:Q0JRZ9 FCHO2	1	FCHO2 [cytosol] (R-HSA-8862260)	0.695	4
UniProt:P52594 AGFG1	1	AGFG1 [cytosol] (R-HSA-8863714)	0.656	3
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.643	5
UniProt:P63010 AP2B1	4	AP2B1 [cytosol] (R-HSA-182166) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [endolysosome membrane] (R-HSA-6784827)	0.643	4
UniProt:P42566 EPS15	2	EPS15 [cytosol] (R-HSA-182920) p-Y849 EPS15 [cytosol] (R-HSA-8867028)	0.641	4
UniProt:Q9Y6I3 EPN1	2	EPN1 [plasma membrane] (R-HSA-182952) EPN1 [cytosol] (R-HSA-8865826)	0.623	2
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.609	2
UniProt:Q13492 PICALM	3	PICALM [cytosol] (R-HSA-8867593) PICALM [cytoplasmic vesicle membrane] (R-HSA-429812) PICALM [Golgi membrane] (R-HSA-434341)	0.59	2
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.564	3
UniProt:Q3UQN2	1	Fcho2 [cytosol] (R-MMU-8862260)	0.557	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	5
UniProt:Q9QYW3 PHOCN			0.544	2
UniProt:Q9QZS3-1 NUMB			0.539	3
UniProt:Q9QZS3-2 NUMB			0.539	3
UniProt:Q9UBC2 EPS15L1	2	EPS15L1 [plasma membrane] (R-HSA-182937) EPS15L1 [cytosol] (R-HSA-8935900)	0.527	3
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.527	3
UniProt:Q9NVZ3 NECAP2	1	NECAP2 [cytosol] (R-HSA-8863466)	0.527	2
UniProt:P0C7W6 CC172			0.527	2
UniProt:Q8N5S1 S2541			0.527	2
UniProt:Q8NBZ0 INO80E	1	INO80E [nucleoplasm] (R-HSA-5689552)	0.527	2
UniProt:Q9HBM1 SPC25	1	SPC25 [cytosol] (R-HSA-375307)	0.527	4
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q10567 AP1B1	5	AP1B1 [cytosol] (R-HSA-167705) AP1B1 [trans-Golgi network membrane] (R-HSA-2130596) AP1B1 [lysosomal membrane] (R-HSA-432699) AP1B1 [Golgi membrane] (R-HSA-350809) AP1B1 [cytoplasmic vesicle membrane] (R-HSA-351181)	0.527	2
UniProt:Q86X29 LSR	1	LSR [plasma membrane] (R-HSA-8933138)	0.527	2
UniProt:Q96FJ0 STAMBPL1	1	STAMBPL1 [cytosol] (R-HSA-6783264)	0.527	2
UniProt:O94973 AP2A2	6	AP2A2(1-939) [endolysosome membrane] (R-HSA-6784819) AP2A2(1-939) [secretory granule membrane] (R-HSA-6800412) AP2A2(1-939) [ficolin-1-rich granule membrane] (R-HSA-6800414) AP2A2(1-939) [plasma membrane] (R-HSA-177502) AP2A2(1-939) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138448) AP2A2(1-939) [cytosol] (R-HSA-182155)	0.527	2
UniProt:P55809 OXCT1	1	OXCT1 [mitochondrial matrix] (R-HSA-74317)	0.527	2
UniProt:O95782 AP2A1	5	AP2A1 [endolysosome membrane] (R-HSA-6784829) AP2A1 [plasma membrane] (R-HSA-177494) AP2A1 [endocytic vesicle membrane] (R-HSA-416641) AP2A1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138449) AP2A1 [cytosol] (R-HSA-182143)	0.527	2
UniProt:P09497 CLTB	5	CLTB [trans-Golgi network membrane] (R-HSA-5333645) CLTB [cytosol] (R-HSA-8856819) CLTB [clathrin-coated endocytic vesicle membrane] (R-HSA-5138428) CLTB [lysosomal membrane] (R-HSA-2980616) CLTB [plasma membrane] (R-HSA-2980617)	0.527	2
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.527	2
UniProt:P98078-1 DAB2			0.463	2

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