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SH3KBP1 [cytosol]
Stable Identifier
R-HSA-182957
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CIN85, Cbl-interacting protein of 85K
Locations in the PathwayBrowser for interactor UniProt:Q9Y6R4 M3K4
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Reelin signalling pathway (Homo sapiens)
RELN:VLDLR:DAB1 binds SH3KBP1 (Homo sapiens)
SH3KBP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96B97 SH3KBP1
Gene Names
SH3KBP1, CIN85
Chain
chain:1-665
Reference Genes
BioGPS Gene:30011 SH3KBP1
COSMIC (genes):SH3KBP1 SH3KBP1
CTD Gene:30011 SH3KBP1
dbSNP Gene:30011 SH3KBP1
ENSEMBL:ENSG00000147010 SH3KBP1
ENSEMBL_homo_sapiens_GENE:ENSG00000147010.19 SH3KBP1
HGNC:13867 SH3KBP1
KEGG Gene (Homo sapiens):30011 SH3KBP1
Monarch:30011 SH3KBP1
NCBI Gene:30011 SH3KBP1
OMIM:300374 SH3KBP1
UCSC:Q96B97 SH3KBP1
Reference Transcript
RefSeq:XM_017029469.1 SH3KBP1
RefSeq:NM_001184960.1 SH3KBP1
RefSeq:NM_031892.2 SH3KBP1
RefSeq:NM_001024666.2 SH3KBP1
Other Identifiers
11724816_a_at
11724817_a_at
11724818_a_at
11724819_a_at
1554168_PM_a_at
1554168_a_at
17109612
223082_PM_at
223082_at
235692_PM_at
235692_at
30011
4001865
4001866
4001867
4001868
4001869
4001871
4001873
4001878
4001880
4001884
4001896
4001898
4001900
4001905
4001909
4001913
4001920
4001928
4001936
4001941
4001954
4001965
4001966
4001978
4001979
4001980
4001994
4001995
4001996
45889_at
8171684
83386_at
A_23_P374782
A_24_P289139
A_33_P3387145
GE54993
GO:0002376
GO:0003824
GO:0005515
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005925
GO:0006897
GO:0006915
GO:0007010
GO:0007015
GO:0007267
GO:0008360
GO:0012501
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0017124
GO:0023052
GO:0030139
GO:0030659
GO:0031410
GO:0031625
GO:0043005
GO:0043226
GO:0045202
GO:0048856
GO:0048870
GO:0050871
GO:0070161
HMNXSV003018719
Hs.31922.0.A1_3p_at
Hs2.153260.2.S1_3p_s_at
ILMN_1652650
ILMN_1808501
ILMN_1810782
PH_hs_0009216
TC0X000903.hg
g7188748_3p_at
Participates
as an input of
RELN:VLDLR:DAB1 binds SH3KBP1 (Homo sapiens)
as a component of
RELN:VLDLR:p-Y198,220,232-DAB1:SH3KBP1 [plasma membrane] (Homo sapiens)
RELN:VLDLR:DAB1:SH3KBP1 [plasma membrane] (Homo sapiens)
SH3KBP1 tetramer [cytosol] (Homo sapiens)
BLNK:GRB2:SOS1:CIN85 [cytosol] (Homo sapiens)
Other forms of this molecule
SH3KBP1 [plasma membrane]
Ub-SH3KBP1 [cytosol]
Inferred To
Ghost homologue of SH3KBP1 [cytosol]
(Danio rerio)
Ghost homologue of SH3KBP1 [cytosol]
(Xenopus tropicalis)
cdap-2 [cytosol]
(Caenorhabditis elegans)
Homologues of SH3KBP1 [cytosol]
(Dictyostelium discoideum)
SH3KBP1 [cytosol]
(Bos taurus)
SH3KBP1 [cytosol]
(Canis familiaris)
SH3KBP1 [cytosol]
(Dictyostelium discoideum)
SH3KBP1 [cytosol]
(Gallus gallus)
SH3KBP1 [cytosol]
(Sus scrofa)
cindr [cytosol]
(Drosophila melanogaster)
Sh3kbp1 [cytosol]
(Mus musculus)
Sh3kbp1 [cytosol]
(Rattus norvegicus)
sfp47 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001171889.1
,
NP_114098.1
,
XP_016884958.1
,
NP_001019837.1
OpenTargets
ENSG00000147010
HPA
ENSG00000147010-SH3KBP1
GeneCards
Q96B97
Ensembl
ENST00000699723
,
ENSP00000369039
,
ENST00000397821
,
ENSP00000514545
,
ENSP00000380921
,
ENST00000379716
,
ENSG00000147010
,
ENSP00000369020
,
ENST00000379698
PRO
Q96B97
Pharos - Targets
Q96B97
PDB
2BZ8
,
2YDL
,
2K9G
,
2O2O
,
2K6D
,
5ABS
,
2N64
Interactors (63)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.974
28
UniProt:Q13191 CBLB
1
CBLB [cytosol]
(R-HSA-976009)
0.939
25
UniProt:Q9ULH1 ASAP1
1
ASAP1 [cytosol]
(R-HSA-5620905)
0.848
13
UniProt:Q99962 SH3GL2
4
SH3GL2 [cytosol]
(R-HSA-182958)
SH3GL2 [plasma membrane]
(R-HSA-177495)
SH3GL2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130629)
SH3GL2 [Golgi membrane]
(R-HSA-351189)
0.788
5
UniProt:P52907 CAPZA1
2
CAPZA1(265-276) [extracellular region]
(R-HSA-879421)
CAPZA1 [cytosol]
(R-HSA-879363)
0.773
7
UniProt:Q9ULZ2 STAP1
0.752
7
UniProt:Q9Y5K6 CD2AP
1
CD2AP [cytosol]
(R-HSA-373620)
0.738
6
UniProt:P47755 CAPZA2
2
CAPZA2 [cytosol]
(R-HSA-879448)
CAPZA2(265-276) [extracellular region]
(R-HSA-879417)
0.725
7
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.695
4
UniProt:Q99963 SH3GL3
1
SH3GL3 [cytosol]
(R-HSA-8867734)
0.691
4
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.683
6
UniProt:O15056 SYNJ2
1
SYNJ2 [cytosol]
(R-HSA-1806193)
0.669
6
UniProt:O43150 ASAP2
0.669
4
UniProt:P98078
3
Dab2 [cytosol]
(R-MMU-8862456)
Dab2 [lysosomal membrane]
(R-MMU-2980807)
Dab2 [plasma membrane]
(R-MMU-2980808)
0.669
9
UniProt:Q8IZC4 RTKN2
0.643
5
UniProt:Q96P48 ARAP1
2
ARAP1 [cytosol]
(R-HSA-3211582)
p-Y231-ARAP1 [cytosol]
(R-HSA-8848869)
0.643
5
UniProt:Q9Y3L3 SH3BP1
1
SH3BP1 [cytosol]
(R-HSA-3006458)
0.643
5
UniProt:A6NNY8 UBP27
0.643
4
UniProt:Q8N3F8 MILK1
0.643
5
UniProt:Q68EM7 ARHGAP17
1
ARHGAP17 [cytosol]
(R-HSA-427895)
0.643
5
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.643
5
UniProt:P78314 3BP2
0.639
8
UniProt:P06729 CD2
1
CD2 [plasma membrane]
(R-HSA-197795)
0.618
3
UniProt:O94850 DEND
0.616
5
UniProt:Q99961 SH3GL1
1
SH3GL1 [cytosol]
(R-HSA-8867732)
0.593
3
UniProt:Q8WUM4 PDCD6IP
1
PDCD6IP [cytosol]
(R-HSA-917717)
0.591
5
UniProt:Q9Y6R4 M3K4
0.591
5
UniProt:Q8WWN8 ARAP3
1
ARAP3 [cytosol]
(R-HSA-195185)
0.564
4
UniProt:Q9JLQ0 Cd2ap
1
CD2AP_MOUSE [cytosol]
(R-MMU-451711)
0.564
2
UniProt:Q3LI67 KRTAP6-3
1
KRTAP6-3 [cytosol]
(R-HSA-6810281)
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:Q5T749 KPRP
1
KPRP [cytosol]
(R-HSA-9839614)
0.556
5
UniProt:Q6PI77 GASP3
0.556
5
UniProt:Q86UU5 GGN
0.556
3
UniProt:Q05BL1 Q05BL1
0.556
3
UniProt:Q9ULE3-2 DENND2A
0.556
3
UniProt:Q7Z783 Q7Z783
0.556
3
IntAct:EBI-22317115 CCSB ORF ID
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q2TAC2-2 CCDC57
0.556
3
UniProt:A6NC98 CC88B
0.556
3
UniProt:Q49AR9 Q49AR9
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:O15156-2 ZBTB7B
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.556
3
UniProt:Q9H3P2 NELFA
1
NELFA [nucleoplasm]
(R-HSA-112426)
0.556
3
UniProt:P53803 POLR2K
2
POLR2K [nucleoplasm]
(R-HSA-63537)
POLR2K [cytosol]
(R-HSA-1964445)
0.556
3
UniProt:P39052 Dnm2
5
DNM2 [Golgi membrane]
(R-RNO-2980842)
DNM2 [endocytic vesicle membrane]
(R-RNO-2029000)
Dnm2 [cytosol]
(R-RNO-9619847)
DNM2 [lysosomal membrane]
(R-RNO-2980840)
Dynamin-2 [plasma membrane]
(R-RNO-941852)
0.544
4
UniProt:P52815 MRPL12
2
MRPL12 [mitochondrial matrix]
(R-HSA-9839674)
MRPL12 [mitochondrial inner membrane]
(R-HSA-5368256)
0.527
2
UniProt:Q96H86 ZNF764
1
ZNF764 [nucleoplasm]
(R-HSA-3343766)
0.527
2
UniProt:Q9NZZ3 CHMP5
1
CHMP5 [cytosol]
(R-HSA-917694)
0.527
2
UniProt:Q8TDR4 TCP1L
0.527
3
UniProt:Q9NVF7 FBX28
0.527
4
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.527
2
UniProt:Q17R89 ARHGAP44
1
ARHGAP44 [cytosol]
(R-HSA-195160)
0.527
2
UniProt:Q9H3D4 TP63
1
TP63 [nucleoplasm]
(R-HSA-2997585)
0.527
2
UniProt:Q9H0B6 KLC2
1
KLC2 [cytosol]
(R-HSA-983191)
0.527
2
UniProt:Q13501 SQSTM1
7
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.524
4
UniProt:Q8CHC4
1
Synj1 [cytosol]
(R-MMU-1604634)
0.524
6
UniProt:P50570 DNM2
5
DNM2 [Golgi membrane]
(R-HSA-2980842)
DNM2 [endocytic vesicle membrane]
(R-HSA-2029000)
DNM2 [cytosol]
(R-HSA-2213180)
DNM2 [lysosomal membrane]
(R-HSA-2980840)
DNM2 [plasma membrane]
(R-HSA-2984201)
0.524
5
UniProt:O43597 SPRY2
8
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
p-S111,S120-SPRY2 [cytosol]
(R-HSA-1295590)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
SPRY2 [plasma membrane]
(R-HSA-182924)
SPRY2 [cytosol]
(R-HSA-182949)
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
0.499
2
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