CBL ubiquitinates Sprouty

Stable Identifier
R-HSA-183051
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Sprouty is ubiquitinated by CBL in an EGF-dependent manner. EGF stimulation induces the tyrosine phosphorylation of Sprouty, which in turn enhances the interaction of Sprouty with CBL. The CBL-mediated ubiquitination of Sprouty targets the protein for degradation by the 26S proteasome.
Literature References
PubMed ID Title Journal Year
12593796 hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

Hall, AB, Jura, N, Gong, D, DaSilva, J, Bar-Sagi, D, Jang, YJ

Curr Biol 2003
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!