Reactome | IFI16 [cytosol]

IFI16 [cytosol]

Stable Identifier

R-HSA-1834934

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Gamma-interferon-inducible protein 16

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q16666 IFI16

Gene Names

IFI16, IFNGIP1

Chain

chain:1-785

Reference Genes

BioGPS Gene:3428 IFI16

COSMIC (genes):IFI16 IFI16

CTD Gene:3428 IFI16

dbSNP Gene:3428 IFI16

ENSEMBL:ENSG00000163565 IFI16

HGNC:5395 IFI16

KEGG:hsa:3428 IFI16

Monarch:3428 IFI16

NCBI Gene:3428 IFI16

OMIM:147586 IFI16

UCSC:Q16666 IFI16

Reference Transcript

Participates

as an input of

IFI16 binds cytosolic dsDNA (Homo sapiens)

as a component of

dsDNA:IFI16 [cytosol] (Homo sapiens)

Cross References

Guide to Pharmacology - Targets

2924

ENSEMBL

ENST00000359709, ENST00000368131, ENST00000368132, ENST00000295809, ENSP00000295809, ENSP00000404325, ENSG00000163565, ENST00000448393, ENSP00000357113, ENSP00000357114, ENSP00000352740

OpenTargets

ENSG00000163565

GeneCards

IFI16

HPA

ENSG00000163565-IFI16

PRO

Q16666

Pharos - Targets

Q16666

GlyGen

Q16666

PDB

2OQ0, 3RLN, 3B6Y, 3RLO, 4QGU, 8X70, 3RNU

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.556	9
UniProt:Q86WV6 STING1	5	STING [endoplasmic reticulum membrane] (R-HSA-1834940) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) TMEM173 [secretory granule membrane] (R-HSA-6804798) TMEM173 [plasma membrane] (R-HSA-6804815)	0.524	2
UniProt:P10275 AR	4	AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.524	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.488	2

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