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pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol]
Stable Identifier
R-HSA-1839043
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)
Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
cytosolic activated FGFR1 fusion mutants [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
Activated FGFR1 mutants and fusions:PLCG1 [cytosol] (Homo sapiens)
Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
cytosolic activated FGFR1 fusion mutants [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
Activated FGFR1 mutants and fusions phosphorylate PLCG1 (Homo sapiens)
Activated FGFR1 mutants and fusion:p-PLCG1 [cytosol] (Homo sapiens)
Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
cytosolic activated FGFR1 fusion mutants [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
Activated FGFR1 mutants and fusions:PLCG1 [cytosol] (Homo sapiens)
Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
cytosolic activated FGFR1 fusion mutants [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
cytosolic activated FGFR1 fusion mutants [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
FGFR1 mutant receptor activation (Homo sapiens)
Signaling by cytosolic FGFR1 fusion mutants (Homo sapiens)
BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Homo sapiens)
p-Y177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2:PIK3R1 [cytosol] (Homo sapiens)
pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2 [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K [cytosol] (Homo sapiens)
p-Y177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2:PIK3R1 [cytosol] (Homo sapiens)
pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2 [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K [cytosol] (Homo sapiens)
p-Y177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2:PIK3R1 [cytosol] (Homo sapiens)
pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2 [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1 (Homo sapiens)
p-Y177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2:PIK3R1 [cytosol] (Homo sapiens)
pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2 [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2 [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
Phosphorylation of BCR moiety of BCR-FGFR1 (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
p-BCR-p-FGFR1 phosphorylates GAB2 (Homo sapiens)
pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2 [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
p-BCR-pFGFR1 binds GRB2:GAB2 (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions (Homo sapiens)
Activated FGFR1 mutants and fusion:p-PLCG1 [cytosol] (Homo sapiens)
Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
cytosolic activated FGFR1 fusion mutants [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
Activated FGFR1 mutants and fusions [plasma membrane] (Homo sapiens)
cytosolic activated FGFR1 fusion mutants [cytosol] (Homo sapiens)
pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
Participants
components
x 2
p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]
(Homo sapiens)
Participates
as an output of
Phosphorylation of BCR moiety of BCR-FGFR1 (Homo sapiens)
as an input of
p-BCR-pFGFR1 binds GRB2:GAB2 (Homo sapiens)
as a component of
pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 [cytosol] (Homo sapiens)
pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2 [cytosol] (Homo sapiens)
as a member of
cytosolic activated FGFR1 fusion mutants [cytosol] (Homo sapiens)
Disease
Name
Identifier
Synonyms
subacute leukemia
DOID:3264
myelodysplastic myeloproliferative cancer
DOID:4972
Myeloproliferative/Myelodysplastic syndromes, unclassifiable myelodysplastic myeloproliferative disease, Unclassifiable Myeloproliferative/Myelodysplastic syndrome, Myelodysplastic/myeloproliferative disease (morphologic abnormality)
acute lymphocytic leukemia
DOID:9952
chronic myeloid leukemia
DOID:8552
CML, chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality), chronic myeloid leukemia, disease (disorder), chronic myeloid leukemia without mention of remission, CML - chronic Myelogenous Leukemia, chronic myeloid leukemia in remission (disorder), Myeloid Leukemia, chronic, CML in Remission, chronic myeloid leukemia in remission, chronic myeloid leukaemia, chronic myeloid leukemia NOS (disorder)
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