Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PDGFA-1 [extracellular region]
Stable Identifier
R-HSA-184199
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
PDGFA isoform 1, Platelet-derived growth factor, A chain isoform 1, PDGF A-chain, Platelet-derived growth factor alpha polypeptide
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
PDGF dimer [extracellular region] (Homo sapiens)
PDGF A homodimer [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF AB heterodimer [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Autophosphorylation of PDGF alpha receptors (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
Downstream signal transduction (Homo sapiens)
Activated PLC gamma dissociates from the PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
Activation of Src (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
Crk binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
GRB2:SOS1 complex binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
Grb7 binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb7 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
Nck binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PI3-kinase binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PLC-gamma binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
Phosphorylation of PLCgamma by PDGFR (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
SH2 domain of Src binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
SHP2 binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
STAT binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
p130Cas and C3G bind PDGFR bound Crk (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF binds to extracellular matrix proteins (Homo sapiens)
PDGF A and B chains with retention motif [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF A and B chains:ECM complex [extracellular region] (Homo sapiens)
PDGF A and B chains with retention motif [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF dimer binds two receptors simultaneously (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF:PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGF-AA clevage by Furin (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGFRs bind type I TKI (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-AA dimer [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
PDGFA-1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04085-1 PDGFA
Gene Names
PDGFA, PDGF1
Other Identifiers
1109_s_at
11729062_a_at
11729063_a_at
11750974_a_at
17054243
205463_PM_s_at
205463_s_at
216867_PM_s_at
216867_s_at
35703_at
4049075
4049082
4049083
4049419
4049421
4049426
4049428
4049430
4049431
4049440
5154
8137670
A_33_P3372666
GE59683
GO:0000139
GO:0001525
GO:0001775
GO:0001942
GO:0002053
GO:0005161
GO:0005515
GO:0005518
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0005902
GO:0006629
GO:0007010
GO:0007267
GO:0008083
GO:0008284
GO:0009611
GO:0009887
GO:0009986
GO:0010512
GO:0010544
GO:0014910
GO:0016020
GO:0023052
GO:0030031
GO:0030036
GO:0030335
GO:0031093
GO:0031410
GO:0031954
GO:0032956
GO:0035790
GO:0035793
GO:0036211
GO:0042060
GO:0042802
GO:0042803
GO:0043226
GO:0043406
GO:0043410
GO:0043588
GO:0046982
GO:0048008
GO:0048018
GO:0048146
GO:0048286
GO:0048407
GO:0048856
GO:0048870
GO:0050730
GO:0050919
GO:0051781
GO:0051897
GO:0060683
GO:0070374
GO:0098772
GO:1990265
GO:1990401
HMNXSV003003506
HMNXSV003023053
HMNXSV003029734
HMNXSV003038532
Hs.37040.2.S1_3p_a_at
ILMN_1685982
ILMN_1782661
ILMN_2342695
M19989_cds2_at
PH_hs_0028268
TC07001073.hg
g4505678_3p_at
Participates
as a component of
PDGF A homodimer [extracellular region] (Homo sapiens)
PDGF AB heterodimer [extracellular region] (Homo sapiens)
as a member of
PDGF A and B chains with retention motif [extracellular region] (Homo sapiens)
Active platelet-derived growth factor A chain isoforms [extracellular region] (Homo sapiens)
Other forms of this molecule
PDGFA-1 [platelet alpha granule lumen]
PDGFA-1(1-211) [endoplasmic reticulum lumen]
N-ter PDGFA-1 fragment [Golgi lumen]
PDGFA-1(1-211) [Golgi membrane]
Inferred To
Pdgfa [extracellular region]
(Mus musculus)
Pdgfa [extracellular region]
(Rattus norvegicus)
Pvf1 [extracellular region]
(Drosophila melanogaster)
PDGFA [extracellular region]
(Bos taurus)
PDGFA [extracellular region]
(Canis familiaris)
PDGFA [extracellular region]
(Sus scrofa)
pdgfab [extracellular region]
(Danio rerio)
PDGF-A (L) [extracellular region]
(Gallus gallus)
pvf-1 [extracellular region]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_002598.4
,
NP_148983.1
OpenTargets
ENSG00000197461
HPA
ENSG00000197461-PDGFA
GeneCards
P04085
ZINC - Substances
PDGFA_HUMAN
Ensembl
ENSP00000383889
,
ENST00000402802
,
ENST00000354513
,
ENSP00000346508
,
ENSG00000197461
ZINC target
P04085
PRO
P04085
Pharos - Targets
P04085
ZINC - Predictions - Purchasable
PDGFA_HUMAN
PDB
3MJK
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P16234 PDGFRA
20
PDGFRA L629P [plasma membrane]
(R-HSA-9673596)
PDGFRA N659K [plasma membrane]
(R-HSA-9671535)
PDGFRA T674I [plasma membrane]
(R-HSA-9673603)
PDGFRA S601P [plasma membrane]
(R-HSA-9673600)
PDGFRA Y288C [endoplasmic reticulum membrane]
(R-HSA-9671971)
PDGFRA Y375_K455del [endoplasmic reticulum membrane]
(R-HSA-9673609)
p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
(R-HSA-9672027)
p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane]
(R-HSA-9673634)
PDGFRA D842_M844del [plasma membrane]
(R-HSA-9671526)
PDGFRA D842Y [plasma membrane]
(R-HSA-9671956)
PDGFRA D842V [plasma membrane]
(R-HSA-9671549)
PDGFRA I843_D846del [plasma membrane]
(R-HSA-9671537)
PDGFRA D842_H845del [plasma membrane]
(R-HSA-9671545)
PDGFRA D842del [plasma membrane]
(R-HSA-9671538)
PDGFRA D842_I843delinsV [plasma membrane]
(R-HSA-9671563)
PDGFRA D846Y [plasma membrane]
(R-HSA-9671958)
PDGFRA D843_845del [plasma membrane]
(R-HSA-9671552)
PDGFRA D842_D846del [plasma membrane]
(R-HSA-9671547)
PDGFRA N848K [plasma membrane]
(R-HSA-9671961)
PDGFRA Y849C [plasma membrane]
(R-HSA-9671974)
0.691
6
UniProt:P09619 PDGFRB
3
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
0.524
5
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text