Reactome | NMT2 [cytosol]

NMT2 [cytosol]

Stable Identifier

R-HSA-184377

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

N-myristoyltransferase 2

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Late Phase of HIV Life Cycle (Homo sapiens)
        
        Assembly Of The HIV Virion (Homo sapiens)
        
        Synthesis And Processing Of GAG, GAGPOL Polyproteins (Homo sapiens)
        
        Membrane binding and targetting of GAG proteins (Homo sapiens)
        
        N-myristoylation of GAG polyprotein by NMT2 (Homo sapiens)
        
        NMT2 [cytosol] (Homo sapiens)

Sensory Perception (Homo sapiens)

- Visual phototransduction (Homo sapiens)
  - The phototransduction cascade (Homo sapiens)
    - Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
      - NMT1/2 transfer MYS to GNAT1 (Homo sapiens)
        
        NMT1/2 [cytosol] (Homo sapiens)
        
        NMT2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60551 NMT2

Gene Names

NMT2

Chain

chain:1-498

Reference Genes

BioGPS Gene:9397 NMT2

COSMIC (genes):NMT2 NMT2

CTD Gene:9397 NMT2

dbSNP Gene:9397 NMT2

ENSEMBL:ENSG00000152465 NMT2

HGNC:7858 NMT2

KEGG:hsa:9397 NMT2

Monarch:9397 NMT2

NCBI Gene:9397 NMT2

OMIM:603801 NMT2

UCSC:O60551 NMT2

Reference Transcript

Other Identifiers

11736512_at

11736513_s_at

11750949_a_at

11757973_x_at

16712046

205005_PM_s_at

205005_s_at

205006_PM_s_at

205006_s_at

215069_PM_at

215069_at

215743_PM_at

215743_at

3279107

3279109

3279110

3279111

3279112

3279113

3279114

3279115

3279116

3279117

3279120

3279121

3279122

3279123

3279124

3279126

3279132

3279133

3279134

3279140

3279141

3279142

41656_at

7932227

9397

A_23_P138686

A_23_P138693

A_33_P3272563

GE81442

GO:0003824

GO:0004379

GO:0005515

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006499

GO:0016020

GO:0016740

GO:0016746

GO:0018008

GO:0018030

GO:0019107

GO:0022400

GO:0043226

GO:0043657

GO:0075733

GO:0140096

HMNXSV003024951

HMNXSV003025173

Hs.122647.0.S1_3p_s_at

Hs.288066.0.S1_3p_at

Hs.94986.1.S1_3p_at

ILMN_2062620

PH_hs_0022160

TC10001061.hg

g4758815_3p_a_at

Participates

as a member of

NMT1/2 [cytosol] (Homo sapiens)

Inferred To

Nmt2 [cytosol] (Rattus norvegicus)

nmt2 [cytosol] (Xenopus tropicalis)

NMT2 [cytosol] (Bos taurus)

NMT2 [cytosol] (Canis familiaris)

NMT2 [cytosol] (Danio rerio)

NMT2 [cytosol] (Dictyostelium discoideum)

NMT2 [cytosol] (Mus musculus)

NMT2 [cytosol] (Saccharomyces cerevisiae)

NMT2 [cytosol] (Schizosaccharomyces pombe)

NMT2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_004799.1, NP_001295224.1

OpenTargets

ENSG00000152465

ENSEMBL

ENSP00000367407, ENST00000378165

IntEnz

2.3.1.97

HPA

ENSG00000152465-NMT2

ZINC - Substances

NMT2_HUMAN

ZINC target

O60551

PRO

O60551

Pharos - Targets

O60551

ZINC - Predictions - Purchasable

NMT2_HUMAN

PDB

6PAU, 4C2X

HMDB Protein

HMDBP01580

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BR61 ACBD6	1	ACBD6 [cytosol] (R-HSA-8848243)	0.827	17
UniProt:Q96KN1 LRAT2			0.641	3
ChEBI:15532 MYRISTOYL-COA			0.618	3
UniProt:P42574 CASP3	5	CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.609	2
linoleoyl-CoA [ChEBI:15530]	2	LA-CoA [endoplasmic reticulum lumen] (R-ALL-2046063) LIN-CoA [mitochondrial matrix] (R-ALL-77359)	0.558	2
ChEBI:15525 PALMITOYL-COA			0.558	2
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:P20290-2 BTF3			0.556	3
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [secretory granule lumen] (R-HSA-6801319) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290)	0.547	2
UniProt:P49006 MRP			0.527	4
UniProt:Q9BY76 ANGPTL4	3	ANGPTL4 [extracellular region] (R-HSA-381271) ANGPTL4 [extracellular region] (R-HSA-6784897) ANGPTL4(164-406) [extracellular region] (R-HSA-9762251)	0.527	3
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.527	3
UniProt:O14880 MGST3	1	MGST3 [endoplasmic reticulum membrane] (R-HSA-176053)	0.527	2
UniProt:Q3SX64 CMA1D			0.527	3
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.527	2
UniProt:Q6P9B6 MEAK7			0.527	2
UniProt:Q8ND25 ZNRF1	1	ZNRF1 [cytosol] (R-HSA-8850903)	0.527	3
UniProt:Q9NWX5 ASB6	1	ASB6 [cytosol] (R-HSA-975412)	0.527	3
UniProt:Q96EF6 FBXO17	1	FBXO17 [cytosol] (R-HSA-976036)	0.527	3
UniProt:P60022 DEFB1	3	DEFB1(?-68) [extracellular region] (R-HSA-975682) DEFB1(?-68) [Golgi lumen] (R-HSA-1467268) DEFB1(1-68) [Golgi lumen] (R-HSA-1467227)	0.527	2
UniProt:P62166 NCS1			0.527	3
UniProt:P60891 PRPS1	1	PRPS1 [cytosol] (R-HSA-73483)	0.527	3

Cite Us!