Reactome | I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol

I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol

Stable Identifier

R-HSA-1855154

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol

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Inositol monophosphatase 1 (IMPA1) and 2 (IMPA2) homodimers dephosphorylate inositol 1-phosphate (I1P) to inositol (Ins). In vitro, IMPA1 and 2 differ in their pH optima and IMPA1 has a significantly greater activity on IP4 than does IMPA2 (McAllister et al. 1992, Ohnishi et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
1377913	cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme Atack, JR, McAllister, G, Knowles, MR, Maigetter, R, Ragan, CI, Whiting, P, Hammond, EA, Bailey, FJ	Biochem J	1992
17068342	Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1 Seo, KC, Sato, Y, Ohba, H, Ohnishi, T, Chung, SK, Furuichi, T, Im, J, Yoshikawa, T, Iwayama, Y	J Biol Chem	2007