1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus

Stable Identifier
R-HSA-1855157
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus
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In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate 1-diphospho-2,3,4,5,6-pentakisphosphate (1-PP-IP5) to make inositol 1,5-bisdiphospho-2,3,4,6-tetrakisphosphate (1,5-(PP)2-IP4) (Saiardi et al. 2001, Mulugu et al. 2007).
Literature References
PubMed ID Title Journal Year
11502751 Identification and characterization of a novel inositol hexakisphosphate kinase

Nagata, E, Saiardi, A, Snyder, SH, Snowman, AM, Luo, HR

J Biol Chem 2001
17412958 A conserved family of enzymes that phosphorylate inositol hexakisphosphate

Haystead, TA, Dollins, DE, Ribeiro, AA, Otto, JC, Bai, W, York, JD, Mulugu, S, Fridy, PC, Bastidas, RJ

Science 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

inositol heptakisphosphate kinase activity of IP6K1/2 [nucleoplasm]

Physical Entity
IP6K1/2 [nucleoplasm] (Homo sapiens)
Activity
inositol heptakisphosphate kinase activity (GO:0000829)
Orthologous Events
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Bos taurus)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Canis familiaris)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Danio rerio)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Dictyostelium discoideum)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Drosophila melanogaster)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Gallus gallus)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Mus musculus)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Plasmodium falciparum)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Rattus norvegicus)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Sus scrofa)
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Xenopus tropicalis)
Cross References
Rhea
Authored
Williams, MG  (2011-10-28)
Reviewed
Wundenberg, T  (2012-11-07)
Created
Williams, MG  (2011-10-28)
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