Reactome | (PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol

(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol

Stable Identifier

R-HSA-1855165

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol

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Diphosphoinositol polyphosphate phosphohydrolases (DIPP), also known as nucleoside diphosphate-linked moiety X motif (NUDT) proteins, dephosphorylate inositol bisdiphospho-tetrakisphosphate ((PP)2-IP4) to inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5). The NUDT proteins involved are: nucleoside diphosphate-linked moiety X motif 3 (NUDT3), 4 (NUDT4), 10 (NUDT10), and 11 (NUDT11). The reactants consumed are: inositol 1,5-bisdiphospho-2,3,4,6-tetrakisphosphate (1,5-(PP)2-IP4) and inositol 3,5-bisdiphospho-1,2,4,6-tetrakisphosphate (3,5-(PP)2-IP4).

The following lists the above proteins with their corresponding literature references: NUDT3 (Safrany et al. 1999, Safrany et al. 1998, Yang et al. 1999, Caffrey et al. 2000), NUDT4 (Caffrey et al. 2000), NUDT10 (Leslie et al. 2002, Hidaka et al. 2002) and NUDT11 (Leslie et al. 2002, Hidaka et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
10585413	Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates Safrany, ST, Yang, X, Shears, SB	J Biol Chem	1999
10419486	The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein Barnes, LD, Safrany, ST, Falck, JR, Ingram, SW, Cartwright, JL, Shears, SB, McLennan, AG	J Biol Chem	1999
12121577	Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases Safrany, ST, Leslie, NR, McLennan, AG	BMC Biochem	2002
12105228	An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase Barnes, LD, Nickel, GC, Zhang, T, Hidaka, K, Falck, JR, Caffrey, JJ, Hua, L, Shears, SB, Carrel, L	J Biol Chem	2002
10777568	Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family Safrany, ST, Caffrey, JJ, Yang, X, Shears, SB	J Biol Chem	2000
9822604	A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase Safrany, ST, Caffrey, JJ, Bembenek, ME, Burkhart, WA, Yang, X, Shears, SB, Moyer, MB	EMBO J	1998