I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol

Stable Identifier
R-HSA-1855179
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Inositolpentakisphosphate 2-kinase (IPPK), also known as IP52K, phosphorylates inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5) to inositol 1,2,3,4,5,6-hexakisphosphate (IP6) (Verbski et al. 2002, Brehm et al. 2007, Choi et al. 2007).

Literature References
PubMed ID Title Journal Year
12084730 The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase

Wente, SR, Majerus, PW, Kisseleva, MV, Wilson, MP, Verbsky, JW

J Biol Chem 2002
17705785 Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase

Nalaskowski, MM, Windhorst, S, Schenk, TM, Kobras, M, Brehm, MA, Mayr, GW, Zhou, X, Shears, SB, Lin, H, Fanick, W

Biochem J 2007
17702752 Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress

Cho, J, Williams, J, Falck, JR, Choi, JH, Shears, SB

J Biol Chem 2007
Participants
Participates
Catalyst Activity

inositol pentakisphosphate 2-kinase activity of IPPK [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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