1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol

Stable Identifier
R-HSA-1855194
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Inositol hexakisphosphate kinase 1 (IP6K1) and 3 (IP6K3) phosphorylate 1-diphospho-2,3,4,5,6-pentakisphosphate (1-PP-IP5) to form inositol 1,5-bisdiphospho-2,3,4,6-tetrakisphosphate (1,5-(PP)2-IP4) (Saiardi et al. 2001, Mulugu et al. 2007).

Literature References
PubMed ID Title Journal Year
17412958 A conserved family of enzymes that phosphorylate inositol hexakisphosphate

Haystead, TA, Dollins, DE, Ribeiro, AA, Otto, JC, Bai, W, York, JD, Mulugu, S, Fridy, PC, Bastidas, RJ

Science 2007
11502751 Identification and characterization of a novel inositol hexakisphosphate kinase

Nagata, E, Saiardi, A, Snyder, SH, Snowman, AM, Luo, HR

J Biol Chem 2001
Participants
Participates
Catalyst Activity

inositol heptakisphosphate kinase activity of IP6K1/3 [cytosol]

Orthologous Events
Cross References
Rhea
Authored
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Created
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