I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol

Stable Identifier
R-HSA-1855219
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol
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Inositol-tetrakisphosphate 1-kinase (ITPK1) dephosphorylates inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5) to inositol 3,4,5,6-tetrakisphosphate (I(3,4,5,6)P4) (Ho et al. 2002).
Literature References
PubMed ID Title Journal Year
11909533 Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase

Zhang, T, Kwon, YU, Potter, BV, Carew, MA, Chung, SK, Riley, AM, Vogel, G, Hua, L, Ho, MW, Yang, X, Shears, SB, Adelt, S

Curr Biol 2002
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Catalyst Activity

inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity of ITPK1:Mg2+ [cytosol]

Physical Entity
ITPK1:Mg2+ [cytosol] (Homo sapiens)
Activity
inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity (GO:0052825)
Orthologous Events
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Bos taurus)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Canis familiaris)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Danio rerio)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Gallus gallus)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Mus musculus)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Sus scrofa)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)
Authored
Williams, MG  (2011-10-28)
Reviewed
Wundenberg, T  (2012-11-07)
Created
Williams, MG  (2011-10-28)
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