5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus

Stable Identifier
R-HSA-1855224
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus
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In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5) to inositol 5-triphospho- 1,2,3,4,6-pentakisphosphate (5-PPP-IP5) (Saiardi et al. 2001, Draskovic et al. 2008) and IP6K2 (Saiardi et al. 2001, Draskovic et al. 2008). While this reaction has been demonstrated to occur in vitro, the extent to which it occurs in vivo is less clear.
Literature References
PubMed ID Title Journal Year
18355727 Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups

Ilc, G, Bhandari, R, Burton, A, Kovacevic, M, Saiardi, A, Podobnik, M, Snyder, SH, Draskovic, P

Chem Biol 2008
11502751 Identification and characterization of a novel inositol hexakisphosphate kinase

Nagata, E, Saiardi, A, Snyder, SH, Snowman, AM, Luo, HR

J Biol Chem 2001
Participants
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Output
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as an event of
Catalyst Activity

inositol 5-diphosphate pentakisphosphate 5-kinase activity of IP6K1/2 [nucleoplasm]

Physical Entity
IP6K1/2 [nucleoplasm] (Homo sapiens)
Activity
inositol 5-diphosphate pentakisphosphate 5-kinase activity (GO:0052836)
Orthologous Events
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Bos taurus)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Canis familiaris)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Danio rerio)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Dictyostelium discoideum)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Drosophila melanogaster)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Gallus gallus)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Mus musculus)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Plasmodium falciparum)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Rattus norvegicus)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Sus scrofa)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Xenopus tropicalis)
Authored
Williams, MG  (2011-10-28)
Reviewed
Wundenberg, T  (2012-11-07)
Created
Williams, MG  (2011-10-28)
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