Reactome | IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen

IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen

Stable Identifier

R-HSA-1855225

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

ReviewStatus

5/5

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IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen

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In the endoplasmic reticulum (ER) lumen, multiple inositol polyphosphate phosphatase 1 (MINPP1) dephosphorylates 1,2,3,4,5,6-hexakisphosphate (IP6) to inositol 1,2,4,5,6-pentakisphosphate (I(1,2,4,5,6)P5) (Caffrey et al. 1999, Chi et al. 1999, Deleu et al. 2006, Nogimori et al. 1991).

Literature References

PubMed ID	Title	Journal	Year
10087200	Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19 Chi, H, Reynolds, PR, O'keefe, RJ, Romano, PR, Rosier, RN, Wang, J, Tiller, GE, Dasouki, MJ, Puzas, JE	Genomics	1999
1653239	Purification of an inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity from rat liver and the evaluation of its substrate specificity Hughes, PJ, Hodgson, ME, Putney JW, Jr, Glennon, MC, Shears, SB, Nogimori, K	J Biol Chem	1991
9923613	The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification Hidaka, K, Matsuda, M, Caffrey, JJ, Hirata, M, Shears, SB	FEBS Lett	1999
15979280	Physiological levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P(5) pool Cho, J, Choi, K, Sulis, ML, Pesesse, X, Parsons, R, Deleu, S, Shears, SB	Cell Signal	2006