PI3K catalyses the phosphorylation of PIP2 to PIP3

Stable Identifier
R-HSA-186800
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PI3K catalyses the phosphorylation of PIP2 to PIP3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The preferred substrate of PI3K is phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] (PIP2), which is phosphorylated to the trisphosphate [PI(3,4,5)P3] (PIP3). PI3-kinase and its products have been found to be of importance in PDGF-stimulated actin reorganization, and directed cell movement, as well as in the stimulation of cell growth and inhibition of apoptosis.

Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane]

Physical Entity
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
Activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Orthologous Events
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Rattus norvegicus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2008-11-24)
Garapati, P V  (2008-11-24)
Reviewed
Heldin, CH  (2008-11-24)
Created
Jassal, B  (2006-08-15)
Cite Us!