Reactome | p-12Y-PDGFRB [plasma membrane]

p-12Y-PDGFRB [plasma membrane]

Stable Identifier

R-HSA-186803

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Phospho-beta PDGF receptor, PGDR_HUMAN, PDGFRB

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
        
        Phospho- PDGF receptor dimer [plasma membrane] (Homo sapiens)
        
        Phospho-alpha-Phospho-beta receptor heterodimer [plasma membrane] (Homo sapiens)
        
        p-12Y-PDGFRB [plasma membrane] (Homo sapiens)
        
        Phospho-beta receptor homodimer [plasma membrane] (Homo sapiens)
        
        p-12Y-PDGFRB [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
        
        PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
        
        Phospho- PDGF receptor dimer [plasma membrane] (Homo sapiens)
        
        Phospho-alpha-Phospho-beta receptor heterodimer [plasma membrane] (Homo sapiens)
        
        p-12Y-PDGFRB [plasma membrane] (Homo sapiens)
        
        Phospho-beta receptor homodimer [plasma membrane] (Homo sapiens)
        
        p-12Y-PDGFRB [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P09619 PDGFRB

Gene Names

PDGFRB, PDGFR, PDGFR1

Chain

signal peptide:1-32, chain:33-1106

Reference Genes

BioGPS Gene:5159 PDGFRB

COSMIC (genes):PDGFRB PDGFRB

CTD Gene:5159 PDGFRB

dbSNP Gene:5159 PDGFRB

ENSEMBL:ENSG00000113721 PDGFRB

ENSEMBL_homo_sapiens_GENE:ENSG00000113721.14 PDGFRB

HGNC:8804 PDGFRB

KEGG Gene (Homo sapiens):5159 PDGFRB

Monarch:5159 PDGFRB

NCBI Gene:5159 PDGFRB

OMIM:173410 PDGFRB

UCSC:P09619 PDGFRB

Reference Transcript

Other Identifiers

11715852_at

11715853_a_at

11715854_at

17001578

1771_s_at

202273_PM_at

202273_at

2881238

2881242

2881243

2881244

2881245

2881246

2881247

2881248

2881249

2881250

2881251

2881252

2881253

2881254

2881256

2881258

2881259

2881262

2881264

2881267

2881268

2881269

2881270

2881273

2881274

2881275

2881276

2881278

2881279

2881281

2881283

2881285

2881286

2881287

2881294

36993_at

5159

74696_r_at

8115099

GE57480

GO:0000166

GO:0000278

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0004992

GO:0005017

GO:0005019

GO:0005102

GO:0005161

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005764

GO:0005773

GO:0005794

GO:0005886

GO:0005925

GO:0006468

GO:0006629

GO:0006935

GO:0007010

GO:0007165

GO:0007169

GO:0007186

GO:0008284

GO:0010863

GO:0014911

GO:0016020

GO:0016301

GO:0016310

GO:0016324

GO:0016740

GO:0018108

GO:0019899

GO:0019901

GO:0023052

GO:0030154

GO:0030335

GO:0031401

GO:0031410

GO:0032516

GO:0032956

GO:0035441

GO:0035791

GO:0035793

GO:0035909

GO:0036120

GO:0036211

GO:0038085

GO:0038091

GO:0043202

GO:0043226

GO:0043231

GO:0043235

GO:0043406

GO:0045840

GO:0045937

GO:0046488

GO:0046777

GO:0048008

GO:0048407

GO:0048584

GO:0048661

GO:0048856

GO:0048870

GO:0050850

GO:0050921

GO:0051897

GO:0055003

GO:0060089

GO:0060326

GO:0060981

GO:0061298

GO:0070374

GO:0071670

GO:0072262

GO:0072277

GO:0090280

GO:0140014

GO:0140096

GO:2000379

GO:2000573

HMNXSV003010193

ILMN_1815057

J03278_at

PH_hs_0023673

TC05001933.hg

TC05003303.hg

g4505682_3p_at

g4505682_3p_x_at

p26300

Participates

as a component of

Other forms of this molecule

p-11Y-PDGFRB [plasma membrane]

PDGFRB [plasma membrane]

Inferred To

Ghost homologue of p-12Y-PDGFRB [plasma membrane] (Danio rerio)

phospho-p-12Y-PDGFRB [plasma membrane] (Bos taurus)

phospho-p-12Y-PDGFRB [plasma membrane] (Caenorhabditis elegans)

phospho-p-12Y-PDGFRB [plasma membrane] (Canis familiaris)

phospho-p-12Y-PDGFRB [plasma membrane] (Drosophila melanogaster)

phospho-p-12Y-PDGFRB [plasma membrane] (Gallus gallus)

phospho-p-12Y-PDGFRB [plasma membrane] (Mus musculus)

phospho-p-12Y-PDGFRB [plasma membrane] (Rattus norvegicus)

phospho-p-12Y-PDGFRB [plasma membrane] (Sus scrofa)

phospho-p-12Y-PDGFRB [plasma membrane] (Xenopus tropicalis)

Homologues of p-12Y-PDGFRB [plasma membrane] (Caenorhabditis elegans)

phospho-kin-36 [plasma membrane] (Caenorhabditis elegans)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1009

Coordinate

1009

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1021

Coordinate

1021

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 579

Coordinate

579

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 581

Coordinate

581

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 716

Coordinate

716

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 740

Coordinate

740

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 751

Coordinate

751

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 763

Coordinate

763

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 771

Coordinate

771

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 775

Coordinate

775

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 778

Coordinate

778

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 857

Coordinate

857

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_011535961.1, XP_011535960.1, NP_002600.1

ZINC - World Drugs

PGFRB_HUMAN

Guide to Pharmacology - Targets

1804

OpenTargets

ENSG00000113721

ZINC - FDA approved

PGFRB_HUMAN

ZINC - Substances

PGFRB_HUMAN

ZINC - Biogenic

PGFRB_HUMAN

ZINC target

P09619

PRO

P09619

PDB

2PLE, 2PLD, 1H9O, 1SHA, 2L6W, 1GQ5, 3MJG, 2IUI

ZINC - Investigational

PGFRB_HUMAN

ZINC - Metabolites

PGFRB_HUMAN

HPA

ENSG00000113721-PDGFRB

GeneCards

P09619

Ensembl

ENSP00000261799, ENST00000261799, ENSG00000113721

Pharos - Targets

P09619

Orphanet

16785

ZINC - Predictions - Purchasable

PGFRB_HUMAN

HMDB Protein

HMDBP01435

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.951	21
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.902	8
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.851	7
UniProt:P23727	3	PIK3R1 [plasma membrane] (R-BTA-198365) PIK3R1 [cytosol] (R-BTA-74789) PIK3R1 [cytosol] (R-BTA-3080572)	0.725	6
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.715	4
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.713	3
UniProt:P16234 PDGFRA	20	PDGFRA L629P [plasma membrane] (R-HSA-9673596) PDGFRA N659K [plasma membrane] (R-HSA-9671535) PDGFRA T674I [plasma membrane] (R-HSA-9673603) PDGFRA S601P [plasma membrane] (R-HSA-9673600) PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971) PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673609) p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027) p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673634) PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526) PDGFRA D842Y [plasma membrane] (R-HSA-9671956) PDGFRA D842V [plasma membrane] (R-HSA-9671549) PDGFRA I843_D846del [plasma membrane] (R-HSA-9671537) PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545) PDGFRA D842del [plasma membrane] (R-HSA-9671538) PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563) PDGFRA D846Y [plasma membrane] (R-HSA-9671958) PDGFRA D843_845del [plasma membrane] (R-HSA-9671552) PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547) PDGFRA N848K [plasma membrane] (R-HSA-9671961) PDGFRA Y849C [plasma membrane] (R-HSA-9671974)	0.706	5
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.704	3
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.675	3
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.643	3
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.643	3
UniProt:P41499 Ptpn11	5	p-Y-Shp2 [cytosol] (R-RNO-1369098) Ptpn11 [cytosol] (R-RNO-548923) PTPN11 [nucleoplasm] (R-RNO-8937745) PTPN11 [cytosol] (R-RNO-162563) phospho-p-Y542,Y580-PTPN11 [cytosol] (R-RNO-162573)	0.59	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q13535 ATR	1	ATR [nucleoplasm] (R-HSA-912443)	0.527	2
UniProt:P35918 Kdr	3	Mouse Vegfr2-Human CSF1R fusion protein [plasma membrane] (R-MMU-5218738) VEGFR2 [plasma membrane] (R-MMU-195382) phospho-p-6Y-VEGFR2 [plasma membrane] (R-MMU-4420103)	0.524	4
UniProt:P04085 PDGFA	1	PDGFA [extracellular region] (R-HSA-2426265)	0.524	5
UniProt:O75581 LRP6	8	p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884) p-S1490-LRP6 [plasma membrane] (R-HSA-206156) LRP6 [early endosome membrane] (R-HSA-5368481) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6N [extracellular region] (R-HSA-5334021) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) LRP6 [plasma membrane] (R-HSA-206252)	0.524	3
UniProt:Q14451 GRB7	1	GRB7 [cytosol] (R-HSA-204819)	0.462	4
UniProt:Q13239 SLA	1	SLA [cytosol] (R-HSA-9706158)	0.462	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.462	2
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2

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