Translocation of p27 to the nucleoplasm

Stable Identifier
R-HSA-187506
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Translocation of p27 to the nucleoplasm
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
p27 translocates to the nucleoplasm where it associates with CyclinE:Cdk2 complexes. Localization of p27 to the nucleus is necessary to inhibit Cdk activation by Cdk-activating kinase.
Literature References
PubMed ID Title Journal Year
9632134 Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells

Orend, G, Ruoslahti, E, Hunter, T

Oncogene 1998
Participants
Input
Output
Participates
as an event of
Orthologous Events
Translocation of p27 to the nucleoplasm (Bos taurus)
Translocation of p27 to the nucleoplasm (Caenorhabditis elegans)
Translocation of p27 to the nucleoplasm (Canis familiaris)
Translocation of p27 to the nucleoplasm (Danio rerio)
Translocation of p27 to the nucleoplasm (Drosophila melanogaster)
Translocation of p27 to the nucleoplasm (Gallus gallus)
Translocation of p27 to the nucleoplasm (Mus musculus)
Translocation of p27 to the nucleoplasm (Rattus norvegicus)
Translocation of p27 to the nucleoplasm (Sus scrofa)
Translocation of p27 to the nucleoplasm (Xenopus tropicalis)
Authored
Pagano, M  (2006-09-19)
Created
Matthews, L  (2006-09-20)
Cite Us!