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CUL1 [nucleoplasm]
Stable Identifier
R-HSA-187551
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cul-1_1
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Association of Cks1 with SCF(Skp2) complex (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Ubiquitination of phospho-p27/p21 (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Association of Cks1 with SCF(Skp2) complex (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Ubiquitination of phospho-p27/p21 (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
BTRC binds p-S344, 347 NFE2L2 (Homo sapiens)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Homo sapiens)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Regulation of BACH1 activity (Homo sapiens)
BACH1:FBXL17 binds SCF(SKP2) complex (Homo sapiens)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Homo sapiens)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner (Homo sapiens)
NPM1-p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
NPM1p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:p-S354 ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1:RBX1:SKP1:p-S354 ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1 (Homo sapiens)
CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
NPM1-p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
FBXW7 Mutants and NOTCH1 in Cancer (Homo sapiens)
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling (Homo sapiens)
FBXW7 WD mutants do not bind NICD1 (Homo sapiens)
FBXW7 WD mutants:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
SCF(SKP2) complex binds RUNX2 (Homo sapiens)
RUNX2:SCF(SKP2) [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
SCF(SKP2) polyubiquitinates RUNX2 (Homo sapiens)
RUNX2:SCF(SKP2) [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
Phosphorylated NICD1 binds FBXW7 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Ubiquitination of NICD1 by FBWX7 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
FBXW7 promotes ubiquitination of p-NICD4 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
CUL1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13616 CUL1
Gene Names
CUL1
Chain
chain:1-776
Reference Genes
BioGPS Gene:8454 CUL1
COSMIC (genes):CUL1 CUL1
CTD Gene:8454 CUL1
dbSNP Gene:8454 CUL1
ENSEMBL:ENSG00000055130 CUL1
ENSEMBL_homo_sapiens_GENE:ENSG00000055130.18 CUL1
HGNC:2551 CUL1
KEGG Gene (Homo sapiens):8454 CUL1
Monarch:8454 CUL1
NCBI Gene:8454 CUL1
OMIM:603134 CUL1
UCSC:Q13616 CUL1
Reference Transcript
RefSeq:XM_011516630.2 CUL1
RefSeq:XM_011516631.2 CUL1
RefSeq:XM_005250060.4 CUL1
RefSeq:XM_011516629.2 CUL1
RefSeq:XM_011516632.2 CUL1
RefSeq:NM_003592.2 CUL1
Other Identifiers
11716819_a_at
11747353_a_at
17053019
207614_PM_s_at
207614_s_at
2874246
3030286
3030287
3030288
3030289
3030290
3030299
3030300
3030301
3030302
3030312
3030313
3030314
3030315
3030316
3030317
3030320
3030321
3030337
3030338
3030339
3030340
3030342
3030343
3030345
3030349
3030354
3030355
3030357
3030359
3030361
3030362
3030363
3030369
39723_at
39724_s_at
8137054
8454
A_23_P59657
A_24_P303589
GE54578
GO:0000082
GO:0000278
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006511
GO:0006513
GO:0006915
GO:0008283
GO:0009887
GO:0012501
GO:0016567
GO:0019005
GO:0023052
GO:0030163
GO:0030674
GO:0031146
GO:0031461
GO:0031625
GO:0036211
GO:0043123
GO:0043161
GO:0043226
GO:0048856
GO:0060090
GO:0070936
GO:0097193
GO:0160072
GO:1990452
HMNXSV003016400
ILMN_1749629
PH_hs_0023905
TC07000969.hg
U58087_at
g4503160_3p_a_at
Participates
as a component of
CUL1:RBX1:SKP1:p-S354 ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
FBXW7 WD mutants:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
G76-NEDD8-K720-CUL1 [cytosol]
CUL1 [cytosol]
Inferred To
cul1 [nucleoplasm]
(Schizosaccharomyces pombe)
cul1 [nucleoplasm]
(Xenopus tropicalis)
cul-1 [nucleoplasm]
(Caenorhabditis elegans)
cul1a [nucleoplasm]
(Danio rerio)
Cul1 [nucleoplasm]
(Drosophila melanogaster)
Cul1 [nucleoplasm]
(Mus musculus)
Cul1 [nucleoplasm]
(Rattus norvegicus)
culB [nucleoplasm]
(Dictyostelium discoideum)
CDC53 [nucleoplasm]
(Saccharomyces cerevisiae)
CUL1 [nucleoplasm]
(Bos taurus)
CUL1 [nucleoplasm]
(Canis familiaris)
CUL1 [nucleoplasm]
(Gallus gallus)
CUL1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
XP_011514932.1
,
XP_005250117.1
,
XP_011514934.1
,
XP_011514931.1
,
XP_011514933.1
,
NP_003583.2
OpenTargets
ENSG00000055130
GeneCards
Q13616
HPA
ENSG00000055130-CUL1
Ensembl
ENST00000665936
,
ENSP00000499255
,
ENST00000662716
,
ENSP00000499398
,
ENST00000409469
,
ENST00000663044
,
ENSG00000055130
,
ENSP00000499277
,
ENSP00000473318
,
ENSP00000387160
,
ENST00000325222
,
ENSP00000326804
,
ENST00000602748
PRO
Q13616
Pharos - Targets
Q13616
PDB
8OR2
,
7B5N
,
1U6G
,
7B5M
,
8OR0
,
7B5L
,
7B5S
,
7B5R
,
8CDJ
,
3TDZ
,
7ZBW
,
7Z8T
,
8OR3
,
7Z8R
,
8OR4
,
3TDU
,
5V89
,
6WCQ
,
4P5O
,
8CDK
,
7Z8V
,
7ZBZ
,
3RTR
,
1LDK
,
6TTU
,
8CAF
,
4F52
,
1LDJ
Interactors (75)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62877 RBX1
2
RBX1 [nucleoplasm]
(R-HSA-1234142)
RBX1 [cytosol]
(R-HSA-180582)
0.978
31
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.961
23
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.957
20
UniProt:Q86VP6 CAND1
5
CAND1 [cytosol]
(R-HSA-5691146)
CAND1 [ficolin-1-rich granule lumen]
(R-HSA-6801399)
CAND1 [extracellular region]
(R-HSA-6806498)
CAND1 [secretory granule lumen]
(R-HSA-6801390)
CAND1 [nucleoplasm]
(R-HSA-8955089)
0.956
33
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.932
15
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.92
13
UniProt:Q969H0 FBXW7
1
FBXW7 [cytosol]
(R-HSA-391304)
0.888
10
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [nucleoplasm]
(R-HSA-975554)
0.823
15
UniProt:Q9UKT5 FBXO4
1
FBXO4 [cytosol]
(R-HSA-391298)
0.813
6
UniProt:Q9Y3I1 FBXO7
1
FBXO7 [cytosol]
(R-HSA-8862627)
0.812
12
UniProt:P61081 UBE2M
5
AcM-UBE2M [nucleoplasm]
(R-HSA-8952502)
G76-NEDD8-C111-AcM-UBE2M [nucleoplasm]
(R-HSA-8952508)
UBE2M [cytosol]
(R-HSA-947619)
AcM-UBE2M [cytosol]
(R-HSA-8951627)
G76-NEDD8-C111-AcM-UBE2M [cytosol]
(R-HSA-4419894)
0.786
5
UniProt:Q9Y4X5 ARIH1
1
ARIH1 [cytosol]
(R-HSA-1678825)
0.773
9
UniProt:Q86XK2 FBXO11
1
FBXO11 [cytosol]
(R-HSA-8955092)
0.758
8
UniProt:Q9NRD1 FBXO6
1
FBXO6 [cytosol]
(R-HSA-391296)
0.744
5
UniProt:Q96EF6 FBXO17
1
FBXO17 [cytosol]
(R-HSA-976036)
0.737
10
UniProt:Q9H469 FBXL15
1
FBXL15 [cytosol]
(R-HSA-8862625)
0.725
8
UniProt:Q92905 COPS5
2
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.723
14
UniProt:Q8N1E6 FBXL14
1
FBXL14 [cytosol]
(R-HSA-8862603)
0.69
6
UniProt:Q6P3S6 FBX42
0.69
9
UniProt:Q9UKT8 FBXW2
1
FBXW2 [cytosol]
(R-HSA-391300)
0.688
6
UniProt:Q96GG9 DCUN1D1
2
DCUN1D1 [nucleoplasm]
(R-HSA-8952487)
DCUN1D1 [cytosol]
(R-HSA-8951781)
0.669
7
UniProt:P41002 CCNF
1
CCNF [cytosol]
(R-HSA-8862602)
0.662
5
UniProt:Q9UK99 FBX3
0.662
9
UniProt:Q16526 CRY1
4
Ub-p-S-CRY1 [nucleoplasm]
(R-HSA-517931)
CRY1 [cytosol]
(R-HSA-400247)
p-S-CRY1 [nucleoplasm]
(R-HSA-400340)
p-S-CRY1 [cytosol]
(R-HSA-400270)
0.643
3
UniProt:Q5XUX0 FBXO31
1
FBXO31 [cytosol]
(R-HSA-8850911)
0.643
4
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.643
5
UniProt:Q9UKA1 FBXL5
1
FBXL5 [cytosol]
(R-HSA-391295)
0.643
4
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.643
3
IntAct:EBI-4399559 UBIQ
0.623
3
UniProt:P46527 CDKN1B
8
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
CDKN1B [cytosol]
(R-HSA-198622)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
0.609
2
UniProt:O94952 FBXO21
1
FBXO21 [cytosol]
(R-HSA-8862592)
0.597
9
UniProt:Q7L5N1 COPS6
2
COPS6 [nucleoplasm]
(R-HSA-5697026)
COPS6 [cytosol]
(R-HSA-416961)
0.597
11
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.597
4
UniProt:Q8TCJ0 FBX25
0.577
3
UniProt:O60826 CCDC22
2
CCDC22 [nucleoplasm]
(R-HSA-8955644)
CCDC22 [cytosol]
(R-HSA-8955640)
0.576
3
UniProt:Q969U6 FBXW5
1
FBXW5 [cytosol]
(R-HSA-391286)
0.564
3
UniProt:Q7Z6M2 FBX33
0.564
2
UniProt:Q13309-1 SKP2
0.564
3
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.564
8
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.564
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:P62837 UBE2D2
4
Ub-C85-UBE2D2 [nucleoplasm]
(R-HSA-8864153)
UBE2D2 [nucleoplasm]
(R-HSA-8852067)
UBE2D2 [cytosol]
(R-HSA-934628)
Ub-C85-UBE2D2 [cytosol]
(R-HSA-8864214)
0.558
2
UniProt:Q83730 MT5
0.556
5
UniProt:Q8BFZ4
1
Fbxl21 [cytosol]
(R-MMU-8862606)
0.547
3
UniProt:Q8C4V4 Fbxl3
2
Fbxl3 [nucleoplasm]
(R-MMU-508623)
Fbxl3 [cytosol]
(R-MMU-391289)
0.547
3
UniProt:P49427 CDC34
4
Ub-C93-CDC34 [cytosol]
(R-HSA-8864170)
Ub-C93-CDC34 [nucleoplasm]
(R-HSA-8864204)
CDC34 [nucleoplasm]
(R-HSA-8852125)
CDC34 [cytosol]
(R-HSA-947621)
0.544
3
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.527
3
UniProt:Q9H4M3 FBXO44
1
FBXO44 [cytosol]
(R-HSA-976031)
0.527
6
UniProt:Q9UH90 FBXO40
1
FBXO40 [cytosol]
(R-HSA-8862612)
0.527
3
UniProt:Q5XUX1 FBXW9
1
FBXW9 [cytosol]
(R-HSA-391290)
0.527
2
UniProt:Q6ZNC4 ZNF704
1
ZNF704 [nucleoplasm]
(R-HSA-2454141)
0.527
2
UniProt:Q99459 CDC5L
1
CDC5L [nucleoplasm]
(R-HSA-5420887)
0.527
2
UniProt:Q8IW75 SPA12
0.527
2
UniProt:Q92990 GLMN
1
GLMN [cytosol]
(R-HSA-8951779)
0.527
2
UniProt:Q9NXK8 FBXL12
1
FBXL12 [cytosol]
(R-HSA-8862611)
0.527
2
UniProt:P41182 BCL6
1
BCL6 [nucleoplasm]
(R-HSA-5223066)
0.527
2
UniProt:Q9UF56 FBXL17
1
FBXL17 [nucleoplasm]
(R-HSA-9708570)
0.527
8
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.527
3
UniProt:P42357 HAL
1
HAL [cytosol]
(R-HSA-70897)
0.527
2
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.527
3
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.524
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.519
7
UniProt:Q8NEZ5 FBXO22
1
FBXO22 [cytosol]
(R-HSA-8862600)
0.499
4
UniProt:Q6TVW2 Q6TVW2
0.499
5
UniProt:Q9BVP2 GNL3
1
GNL3 [nucleoplasm]
(R-HSA-8869324)
0.483
2
UniProt:Q16629 SRSF7
1
SRSF7 [nucleoplasm]
(R-HSA-72029)
0.483
2
UniProt:P61201 COPS2
2
COPS2 [cytosol]
(R-HSA-416971)
COPS2 [nucleoplasm]
(R-HSA-5697012)
0.462
6
UniProt:Q8N3Y1 FBXW8
1
FBXW8 [cytosol]
(R-HSA-976017)
0.462
2
UniProt:Q9UBW8 COPS7A
2
COPS7A [nucleoplasm]
(R-HSA-5697011)
COPS7A [cytosol]
(R-HSA-416964)
0.462
6
UniProt:Q96ME1 FBXL18
1
FBXL18 [cytosol]
(R-HSA-8854063)
0.462
6
UniProt:Q99627 COPS8
2
COPS8 [cytosol]
(R-HSA-416962)
COPS8 [nucleoplasm]
(R-HSA-5697014)
0.462
6
UniProt:Q13098 GPS1
2
GPS1 [nucleoplasm]
(R-HSA-5697010)
GPS1 [cytosol]
(R-HSA-416972)
0.462
5
UniProt:Q9H9Q2 COPS7B
2
COPS7B [cytosol]
(R-HSA-416966)
COPS7B [nucleoplasm]
(R-HSA-5697023)
0.462
6
UniProt:Q9BT78 COPS4
2
COPS4 [nucleoplasm]
(R-HSA-5697020)
COPS4 [cytosol]
(R-HSA-416965)
0.462
6
UniProt:Q9UNS2 COPS3
2
COPS3 [cytosol]
(R-HSA-416973)
COPS3 [nucleoplasm]
(R-HSA-5697017)
0.462
6
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