Reactome | Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

Stable Identifier

R-HSA-187552

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The association of Cks1 with both Skp2 and phosphorylated p27 promotes a tight interaction between p27 and the SCF complex (Hao et al., 2005).

Literature References

PubMed ID	Title	Journal	Year
15199159	Noncatalytic requirement for cyclin A-cdk2 in p27 turnover Traganos, F, Zhu, XH, Koff, A, Nguyen, H, Halicka, HD	Mol Cell Biol	2004
16209941	Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase Pavletich, NP, Miller, JJ, Wu, G, Schulman, BA, Pagano, M, Zheng, N, Hao, B	Mol Cell	2005
11231585	The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27 Ko, TK, Ganoth, D, Hershko, A, Bornstein, G, Tyers, M, Pagano, M, Larsen, B	Nat Cell Biol	2001
10375532	p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27 Sun, H, Zhang, H, Tsvetkov, LM, Lee, SJ, Yeh, KH	Curr Biol	1999