Degradation of ubiquitinated p27/p21 by the 26S proteasome

Stable Identifier
R-HSA-187574
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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Degradation of ubiquitinated p27/p21 by the 26S proteasome
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Following ubiquitination by the SCF(Skp2):Cks1 complex, phospho-p27/p21 is degraded by the 26S proteasome.

Literature References
PubMed ID Title Journal Year
10559916 SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Eytan, E, Hershko, A, Pagano, M, Carrano, AC

Nat Cell Biol 1999
10375532 p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

Sun, H, Zhang, H, Tsvetkov, LM, Lee, SJ, Yeh, KH

Curr Biol 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

Physical Entity
26S proteasome [nucleoplasm] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Danio rerio)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Dictyostelium discoideum)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Rattus norvegicus)
Authored
Pagano, M  (2006-09-19)
Reviewed
Coqueret, O  (2006-10-06)
Created
Matthews, L  (2006-09-20)
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