Reactome | MAPKAPK2 [cytosol]

MAPKAPK2 [cytosol]

Stable Identifier

R-HSA-187743

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MAP kinase-activated protein kinase 2, MKK2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P49137 MAPKAPK2

Gene Names

MAPKAPK2

Chain

chain:1-400

Reference Genes

BioGPS Gene:9261 MAPKAPK2

COSMIC (genes):MAPKAPK2 MAPKAPK2

CTD Gene:9261 MAPKAPK2

dbSNP Gene:9261 MAPKAPK2

ENSEMBL:ENSG00000162889 MAPKAPK2

HGNC:6887 MAPKAPK2

KEGG:hsa:9261 MAPKAPK2

Monarch:9261 MAPKAPK2

NCBI Gene:9261 MAPKAPK2

OMIM:602006 MAPKAPK2

UCSC:P49137 MAPKAPK2

Reference Transcript

Participates

as a member of

MAPKAP kinase [cytosol] (Homo sapiens)

Other forms of this molecule

MAPKAPK2 [nucleoplasm]

p-T222,S272,T334-MAPKAPK2 [nucleoplasm]

p-S272,T222,T334-MAPKAPK2 [cytosol]

p-T222,S272-MAPKAPK2 [nucleoplasm]

Inferred To

Homologues of MAPKAPK2 [cytosol] (Caenorhabditis elegans)

Homologues of MAPKAPK2 [cytosol] (Plasmodium falciparum)

MAPKAPK2 [cytosol] (Bos taurus)

MAPKAPK2 [cytosol] (Caenorhabditis elegans)

MAPKAPK2 [cytosol] (Danio rerio)

MAPKAPK2 [cytosol] (Drosophila melanogaster)

MAPKAPK2 [cytosol] (Gallus gallus)

MAPKAPK2 [cytosol] (Mus musculus)

MAPKAPK2 [cytosol] (Plasmodium falciparum)

MAPKAPK2 [cytosol] (Rattus norvegicus)

MAPKAPK2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_116584.2, NP_004750.1

Guide to Pharmacology - Targets

2094

OpenTargets

ENSG00000162889

ENSEMBL

ENSP00000294981, ENST00000294981, ENST00000367103, ENSP00000356070, ENSG00000162889

ZINC - Substances

MAPK2_HUMAN

ZINC - Biogenic

MAPK2_HUMAN

ZINC target

P49137

PRO

P49137

PDB

8XU4, 3M2W, 2ONL, 2PZY, 3KGA, 3R2B, 3R30, 2OZA, 7NRY, 3KC3, 3FYJ, 6TCA, 3FYK, 6T8X, 3GOK, 3A2C, 3WI6, 1NY3, 3KA0, 3FPM, 3M42, 4TYH, 2P3G, 1KWP, 2OKR, 8XX1, 2JBP, 2JBO, 3R2Y, 1NXK

ZINC - Investigational

MAPK2_HUMAN

ZINC - Metabolites

MAPK2_HUMAN

HPA

ENSG00000162889-MAPKAPK2

GeneCards

MAPKAPK2

Pharos - Targets

P49137

ZINC - Predictions - Purchasable

MAPK2_HUMAN

HMDB Protein

HMDBP02904

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16539 MAPK14	7	p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) MAPK14 [cytosol] (R-HSA-428933) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300)	0.93	15
UniProt:Q15759 MAPK11	4	p-T180,Y182-MAPK11 [cytosol] (R-HSA-171009) MAPK11 [cytosol] (R-HSA-170989) MAPK11 [nucleoplasm] (R-HSA-203790) p-T180,Y182-MAPK11 [nucleoplasm] (R-HSA-198741)	0.643	4
UniProt:Q00613 HSF1	11	HSF1 [cytosol] (R-HSA-3371452) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) hC36,103-HSF1 [cytosol] (R-HSA-4793916) HSF1 [nucleoplasm] (R-HSA-5082385) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906)	0.602	5
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.571	3
UniProt:Q16644 MAPKAPK3	4	MAPKAPK3 [nucleoplasm] (R-HSA-450218) p-S,2T-MAPKAPK3 [nucleoplasm] (R-HSA-450359) p-S,2T-MAPKAPK3 [cytosol] (R-HSA-187723) MAPKAPK3 [cytosol] (R-HSA-187764)	0.527	3
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.488	2

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