RIT/RIN are activated

Stable Identifier
R-HSA-187746
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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RIT/RIN are activated
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RIT and RIN are activated by neurotrophins through unknown exchange factors. Activation reaches a maximal level between 5 and 15 min after NGF stimulation and remains elevated for at least 2 h. RIN, which is neuron-specific, might function as a component of a neuron specific B-RAF signalosome complex, in which RIN provides spatial and/or substrate specificity to the B-RAF-MEK kinase cascade to direct stimulation of p38 signaling.
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Catalyst Activity

guanyl-nucleotide exchange factor activity of Guanine nucleotide exchange factor [cytosol]

Physical Entity
Guanine nucleotide exchange factor [cytosol] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Inferred From
Rit is activated (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2006-09-21)
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