Reactome | XYLTs transfer Xyl to core protein

XYLTs transfer Xyl to core protein

Stable Identifier

R-HSA-1878002

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

Synonyms

Xylose is transferred to a serine residue on the core protein

ReviewStatus

5/5

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Xylosyltransferases (XYLT1, XYLT2) catalyse the initial step in the tetrasaccharide linkage required forglycosaminoglycan biosynthesis. This reaction can take place in the Golgi apparatus and endoplasmic reticulum (not shown here). XYLTs mediates the transfer of xylose from the active nucleotide sugar UDP-xylose to specific serine hydroxy groups in the core protein. A C-terminal DxD motif on the enzyme is thought to be critical for activity (Muller et al. 2005, Goetting et al. 2004, Voglmeir et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
15461586	Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity Müller, S, Schöttler, M, Schön, S, Prante, C, Brinkmann, T, Kuhn, J, Götting, C, Kleesiek, K	Biochem J	2005
17194707	XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity Voglmeir, J, Voglauer, R, Wilson, IB	J. Biol. Chem.	2007
15294915	Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity Götting, C, Müller, S, Schöttler, M, Schön, S, Prante, C, Brinkmann, T, Kuhn, J, Kleesiek, K	J Biol Chem	2004
11099377	Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II Götting, C, Kuhn, J, Zahn, R, Brinkmann, T, Kleesiek, K	J Mol Biol	2000