Reactome | Translocation of p21 to the nucleus

Translocation of p21 to the nucleus

Stable Identifier

R-HSA-187828

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        Translocation of p21 to the nucleus (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - Translocation of p21 to the nucleus (Homo sapiens)

General

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SVG | | PPTX | SBGN

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p21 associates with and inhibits Cyclin:Cdk complexes in the nucleus.

Literature References

PubMed ID	Title	Journal	Year
9632134	Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells Orend, G, Hunter, T, Ruoslahti, E	Oncogene	1998