Reactome | EEA1 [endosome membrane]

EEA1 [endosome membrane]

Stable Identifier

R-HSA-187893

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15075 EEA1

Gene Names

EEA1, ZFYVE2

Chain

chain:1-1411

Reference Genes

BioGPS Gene:8411 EEA1

COSMIC (genes):EEA1 EEA1

CTD Gene:8411 EEA1

dbSNP Gene:8411 EEA1

ENSEMBL:ENSG00000102189 EEA1

HGNC:3185 EEA1

KEGG:hsa:8411 EEA1

Monarch:8411 EEA1

NCBI Gene:8411 EEA1

OMIM:605070 EEA1

UCSC:Q15075 EEA1

Reference Transcript

RefSeq:NM_003566.3 EEA1

Other Identifiers

11724301_a_at

11724302_a_at

11750257_a_at

16768478

204840_PM_s_at

204840_s_at

204841_PM_s_at

204841_s_at

225885_PM_at

225885_at

3465594

3465595

3465596

3465597

3465598

3465599

3465600

3465601

3465602

3465603

3465604

3465606

3465608

3465609

3465610

3465611

3465612

3465613

3465614

3465615

3465617

3465618

3465619

3465620

3465622

3465624

3465625

3465628

3465631

3465632

3465633

3465634

3465635

3465639

3465640

3465641

3465642

3465644

3465645

3465657

3465666

39627_at

50373_at

7965436

8411

A_23_P64762

A_23_P76159

GE81302

GE88824

GO:0005515

GO:0005516

GO:0005545

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005969

GO:0006897

GO:0006906

GO:0008270

GO:0008289

GO:0016020

GO:0016189

GO:0016192

GO:0030742

GO:0031410

GO:0031901

GO:0042803

GO:0043226

GO:0044308

GO:0044788

GO:0045022

GO:0046872

GO:0050877

GO:0055037

GO:0061024

GO:0070062

GO:0098685

GO:0098830

GO:0098842

GO:0098978

GO:0099565

HMNXSV003027195

Hs.24370.0.S1_3p_at

Hs.2864.0.S1_3p_a_at

ILMN_1743194

L40157_at

PH_hs_0000364

TC12001811.hg

g4503468_3p_a_at

Participates

as a component of

EEA1:EEA1 [endosome membrane] (Homo sapiens)

Inferred To

EEA1 [endosome membrane] (Bos taurus)

EEA1 [endosome membrane] (Canis familiaris)

EEA1 [endosome membrane] (Mus musculus)

EEA1 [endosome membrane] (Sus scrofa)

Eea1 [endosome membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_003557.2

ENSEMBL

ENST00000322349, ENSP00000317955

OpenTargets

ENSG00000102189

HPA

ENSG00000102189-EEA1

PRO

Q15075

Pharos - Targets

Q15075

GlyGen

Q15075

HMDB Protein

HMDBP02426

PDB

1HYJ, 1HYI, 1JOC, 3MJH

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20339 RAB5A	7	RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125)	0.765	4
UniProt:Q63635	2	Stx6 [Golgi membrane] (R-RNO-6811004) Stx6 [trans-Golgi network membrane] (R-RNO-6811007)	0.581	4
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.567	5
UniProt:Q7Z3T8 ZFYVE16	1	ZFYVE16 [early endosome membrane] (R-HSA-201645)	0.536	4
UniProt:P05120 SERPINB2	2	SERPINB2 [plasma membrane] (R-HSA-159004) SERPINB2 [extracellular region] (R-HSA-158997)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11

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