CAK-mediated phosphorylation of Cyclin A:Cdk2

Stable Identifier
R-HSA-187949
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase (CAK) is required for the activation of the CDK kinase activity. The association of p21/p27 with the Cyclin A/E:Cdk2 complex prevents CAK mediated phosphorylation of Cdk2 (Aprelikova et al., 1995).

Literature References
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Participates
Catalyst Activity

protein serine/threonine kinase activity of CAK [nucleoplasm]

Orthologous Events
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