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PIK3C3 [cytosol]
Stable Identifier
R-HSA-188011
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PI3K class III Catalytic subunit, VPS34
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Homo sapiens)
AMBRA1:DYNLL1,DYNLL2:BECN1 complex [cytosol] (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Autophagosome maturation (Homo sapiens)
UVRAG complex [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
BECN1 complex:p-AMBRA1:DYNLL1,DYNLL2 [cytosol] (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Beclin-1 complex phosphorylates PtdIns (Homo sapiens)
ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [endoplasmic reticulum membrane] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Beclin-1 complex translocates to the ER (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
The phagophore extends from the PIP3-enriched structure (Homo sapiens)
ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [endoplasmic reticulum membrane] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [phagophore assembly site membrane] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)
AMBRA1:DYNLL1,DYNLL2:BECN1 complex [cytosol] (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
BECN1 complex:p-AMBRA1:DYNLL1,DYNLL2 [cytosol] (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
ULK1 phosphorylates Beclin-1 (Homo sapiens)
ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [endoplasmic reticulum membrane] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Enhanced autophagosome formation (Homo sapiens)
UVRAG complex [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Enhanced autophagosome formation (Homo sapiens)
UVRAG complex [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Capturing cargo and formation of prebudding complex (Homo sapiens)
8:class I MHC:BECN1 complex [endoplasmic reticulum membrane] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
SARS-CoV-2 8:class I MHC binds BECN1 (Homo sapiens)
8:class I MHC:BECN1 complex [endoplasmic reticulum membrane] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
Capturing cargo and formation of prebudding complex (Homo sapiens)
8:class I MHC:BECN1 complex [endoplasmic reticulum membrane] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
Rab5-mediated recruitment of class III PI3K to TLR9 (Homo sapiens)
PI3K class III [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
activated TLR9:PI3K class III [cytosol] (Homo sapiens)
PI3K class III [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the Golgi membrane (Homo sapiens)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Homo sapiens)
PIK3C2A/3 [cytosol] (Homo sapiens)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Homo sapiens)
PIK3C3:Mn2+ [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Synthesis of PIPs at the early endosome membrane (Homo sapiens)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Homo sapiens)
PIK3C2A/3 [cytosol] (Homo sapiens)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Homo sapiens)
PIK3C3:Mn2+ [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Synthesis of PIPs at the late endosome membrane (Homo sapiens)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Homo sapiens)
PIK3C2A/3 [cytosol] (Homo sapiens)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Homo sapiens)
PIK3C3:Mn2+ [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
activated TLR9:PI3K class III [cytosol] (Homo sapiens)
PI3K class III [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
activated TLR9:PI3K class III [cytosol] (Homo sapiens)
PI3K class III [cytosol] (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate NADPH Oxidases (Homo sapiens)
PIK3C3:PIK3R4 phosphorylates PI to PI3P (Homo sapiens)
PIK3C3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NEB9 PIK3C3
Gene Names
PIK3C3, VPS34
Chain
chain:1-887
Reference Genes
BioGPS Gene:5289 PIK3C3
COSMIC (genes):PIK3C3 PIK3C3
CTD Gene:5289 PIK3C3
dbSNP Gene:5289 PIK3C3
ENSEMBL:ENSG00000078142 PIK3C3
ENSEMBL_homo_sapiens_GENE:ENSG00000078142.14 PIK3C3
HGNC:8974 PIK3C3
KEGG Gene (Homo sapiens):5289 PIK3C3
Monarch:5289 PIK3C3
NCBI Gene:5289 PIK3C3
OMIM:602609 PIK3C3
UCSC:Q8NEB9 PIK3C3
Reference Transcript
RefSeq:NM_002647.3 PIK3C3
Other Identifiers
11755049_a_at
16852098
204297_PM_at
204297_at
229705_PM_at
229705_at
232086_PM_at
232086_at
239300_PM_at
239300_at
35665_at
3786079
3786080
3786081
3786082
3786083
3786096
3786097
3786099
3786101
3786102
3786103
3786105
3786108
3786109
3786115
3786117
3786118
3786120
3786121
3786124
3786127
3786129
3786135
3786137
3786139
3786146
3786147
3786148
3786149
3786150
3786151
3786152
3786153
3786154
3786155
3786156
3786189
5289
61096_at
8021015
A_14_P111156
A_14_P117012
A_14_P123049
A_23_P164536
A_24_P288116
GE60410
GE665503
GE88078
GO:0000045
GO:0000166
GO:0000407
GO:0000910
GO:0003824
GO:0004672
GO:0005515
GO:0005524
GO:0005737
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005776
GO:0005777
GO:0005829
GO:0005856
GO:0005929
GO:0005930
GO:0006497
GO:0006622
GO:0006629
GO:0006886
GO:0006897
GO:0006914
GO:0007049
GO:0009267
GO:0010506
GO:0016020
GO:0016192
GO:0016236
GO:0016241
GO:0016301
GO:0016303
GO:0016310
GO:0016740
GO:0023052
GO:0030242
GO:0030496
GO:0030670
GO:0031410
GO:0032465
GO:0034271
GO:0034272
GO:0034497
GO:0035032
GO:0036092
GO:0036211
GO:0042149
GO:0043226
GO:0044754
GO:0044829
GO:0045022
GO:0045335
GO:0046854
GO:0048015
GO:0051301
GO:0061912
GO:0097352
GO:0140096
HMNXSV003018200
Hs.193041.0.A1_3p_at
Hs.239340.0.S1_3p_at
Hs.239340.0.S1_3p_x_at
Hs.3734.0.A1_3p_at
ILMN_1687896
PH_hs_0012896
PH_hs_0025089
TC18000156.hg
TC18000689.hg
Z46973_at
g4505800_3p_at
Participates
as a component of
PI3K class III [cytosol] (Homo sapiens)
PIK3C3:Mn2+ [cytosol] (Homo sapiens)
UVRAG complex [cytosol] (Homo sapiens)
ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [phagophore assembly site membrane] (Homo sapiens)
ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [endoplasmic reticulum membrane] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
Other forms of this molecule
PIK3C3 [phagocytic vesicle membrane]
Inferred To
Pi3K59F [cytosol]
(Drosophila melanogaster)
vps-34 [cytosol]
(Caenorhabditis elegans)
VPS34 [cytosol]
(Saccharomyces cerevisiae)
vps34 [cytosol]
(Schizosaccharomyces pombe)
Ghost homologue of PIK3C3 [cytosol]
(Xenopus tropicalis)
Pik3c3 [cytosol]
(Mus musculus)
Pik3c3 [cytosol]
(Rattus norvegicus)
pikE [cytosol]
(Dictyostelium discoideum)
PIK3C3 [cytosol]
(Bos taurus)
PIK3C3 [cytosol]
(Canis familiaris)
PIK3C3 [cytosol]
(Gallus gallus)
PIK3C3 [cytosol]
(Plasmodium falciparum)
PIK3C3 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_002638.2
Guide to Pharmacology - Targets
2152
OpenTargets
ENSG00000078142
ZINC - Substances
PK3C3_HUMAN
ZINC target
Q8NEB9
PRO
Q8NEB9
PDB
6HOG
,
5ENN
,
4UWL
,
7RSJ
,
6YKG
,
4OYS
,
7RSP
,
3LS8
,
6HOH
,
3IHY
,
4UWF
,
7RSV
,
4UWG
,
8SOR
,
7BL1
,
4UWH
,
6I3U
,
4UWK
,
4PH4
,
8SRQ
,
5ANL
ZINC - Investigational
PK3C3_HUMAN
IntEnz
2.7.1.137
HPA
ENSG00000078142-PIK3C3
GeneCards
Q8NEB9
Ensembl
ENST00000262039
,
ENSG00000078142
,
ENSP00000262039
Pharos - Targets
Q8NEB9
ZINC - Predictions - Purchasable
PK3C3_HUMAN
HMDB Protein
HMDBP03992
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14457 BECN1
4
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
BECN1 [cytosol]
(R-HSA-1632841)
0.967
39
UniProt:Q9P2Y5 UVRAG
2
UVRAG [cytosol]
(R-HSA-5668884)
UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9730510)
0.929
23
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