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SIGIRR [plasma membrane]
Stable Identifier
R-HSA-188067
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
SIGRR
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-37 signaling (Homo sapiens)
IL37:IL18R1 binds SIGIRR (Homo sapiens)
IL18R1:IL37,IL37(?-218):SIGIRR [plasma membrane] (Homo sapiens)
SIGIRR [plasma membrane] (Homo sapiens)
SIGIRR [plasma membrane] (Homo sapiens)
STAT3 phosphorylation (Homo sapiens)
IL18R1:IL37,IL37(?-218):SIGIRR [plasma membrane] (Homo sapiens)
SIGIRR [plasma membrane] (Homo sapiens)
TBK1 phosphorylation (Homo sapiens)
IL18R1:IL37,IL37(?-218):SIGIRR [plasma membrane] (Homo sapiens)
SIGIRR [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
SIGIRR [plasma membrane] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
SIGIRR [plasma membrane] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
SIGIRR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6IA17 SIGIRR
Gene Names
SIGIRR, UNQ301/PRO342
Chain
chain:1-410
Reference Genes
BioGPS Gene:59307 SIGIRR
COSMIC (genes):SIGIRR SIGIRR
CTD Gene:59307 SIGIRR
dbSNP Gene:59307 SIGIRR
ENSEMBL:ENSG00000185187 SIGIRR
ENSEMBL_homo_sapiens_GENE:ENSG00000185187.13 SIGIRR
HGNC:30575 SIGIRR
KEGG Gene (Homo sapiens):59307 SIGIRR
Monarch:59307 SIGIRR
NCBI Gene:59307 SIGIRR
OMIM:605478 SIGIRR
UCSC:Q6IA17 SIGIRR
Reference Transcript
RefSeq:NM_001135054.1 SIGIRR
RefSeq:NM_001135053.1 SIGIRR
RefSeq:NM_021805.2 SIGIRR
Other Identifiers
11734335_a_at
11734336_x_at
16733858
218921_PM_at
218921_at
3357886
3357887
3357890
3357893
3357895
3357897
3357898
3357899
3357900
3357901
3357902
3357903
3357904
3357905
3357906
3357907
3357908
52940_PM_at
52940_at
59307
79428_s_at
7945377
A_23_P84344
GE62087
GO:0001960
GO:0005515
GO:0005886
GO:0006351
GO:0006355
GO:0006953
GO:0006954
GO:0007165
GO:0016020
GO:0023052
GO:0031665
GO:0032682
GO:0043433
HMNXSV003019956
HMNXSV003026276
ILMN_1736965
ILMN_1807981
PH_hs_0020077
TC11001231.hg
TC11002980.hg
g11141876_3p_s_at
Participates
as an input of
IL37:IL18R1 binds SIGIRR (Homo sapiens)
as a component of
IL18R1:IL37,IL37(?-218):SIGIRR [plasma membrane] (Homo sapiens)
This entity regulates
Negatively
MyD88 forms a complex with TIRAP:activated TLR2/4
(Homo sapiens)
Inferred To
sc:d148 [plasma membrane]
(Danio rerio)
sigirr [plasma membrane]
(Xenopus tropicalis)
SIGIRR [plasma membrane]
(Bos taurus)
SIGIRR [plasma membrane]
(Canis familiaris)
SIGIRR [plasma membrane]
(Gallus gallus)
SIGIRR [plasma membrane]
(Sus scrofa)
Sigirr [plasma membrane]
(Mus musculus)
Sigirr [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001128526.1
,
NP_001128525.1
,
NP_068577.2
Guide to Pharmacology - Targets
2969
OpenTargets
ENSG00000185187
GeneCards
Q6IA17
HPA
ENSG00000185187-SIGIRR
Ensembl
ENST00000397632
,
ENSP00000403104
,
ENSP00000333656
,
ENSG00000185187
,
ENSP00000380756
,
ENST00000332725
,
ENST00000431843
PRO
Q6IA17
Pharos - Targets
Q6IA17
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:A6NDB9 PALM3
0.508
4
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