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PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm]
Stable Identifier
R-HSA-188192
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
17187060
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
Binné, UK
,
Kaelin, WG
,
Rape, M
,
Classon, MK
,
Wei, W
,
Dyson, NJ
,
Dick, FA
,
Näär, AM
Nat. Cell Biol.
2007
Participants
components
Cdh1:phospho-APC/C complex [nucleoplasm]
(Homo sapiens)
PolyUb-SKP2 [nucleoplasm]
(Homo sapiens)
RB1 [nucleoplasm]
(Homo sapiens)
Participates
as an output of
APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)
as an input of
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
Inferred To
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm]
(Bos taurus)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm]
(Canis familiaris)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm]
(Dictyostelium discoideum)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm]
(Drosophila melanogaster)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm]
(Gallus gallus)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm]
(Mus musculus)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm]
(Rattus norvegicus)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm]
(Sus scrofa)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm]
(Xenopus tropicalis)
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