Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MYC [nucleoplasm]
Stable Identifier
R-HSA-188379
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser for interactor UniProt:P26641 EEF1G
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
Regulation of NFE2L2 gene expression (Homo sapiens)
MYC binds the NFE2L2 promoter (Homo sapiens)
MYC [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA (Homo sapiens)
MYC [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NOTCH1 PEST domain mutants stimulate MYC transcription (Homo sapiens)
MYC [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NOTCH1 PEST domain mutants stimulate MYC transcription (Homo sapiens)
MYC [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex (Homo sapiens)
MYC [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates WNT signaling (Homo sapiens)
TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene (Homo sapiens)
MYC [nucleoplasm] (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of cell cycle factors (Homo sapiens)
TFAP2C homodimer binds MYC and KDM5B (Homo sapiens)
MYC [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
MYC binds MAPKAPK5 gene (Homo sapiens)
MYC [nucleoplasm] (Homo sapiens)
MYC mRNA translation is negatively regulated by miR-34B and C (Homo sapiens)
MYC [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
NOTCH1 stimulates MYC transcription (Homo sapiens)
MYC [nucleoplasm] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
Estrogen-responsive MYC gene expression (Homo sapiens)
MYC [nucleoplasm] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex (Homo sapiens)
MYC [nucleoplasm] (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Binding of TCF/LEF:CTNNB1 to target gene promoters (Homo sapiens)
TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene (Homo sapiens)
MYC [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01106 MYC
Gene Names
MYC, BHLHE39
Chain
chain:1-454
Reference Genes
BioGPS Gene:4609 MYC
COSMIC (genes):MYC MYC
CTD Gene:4609 MYC
dbSNP Gene:4609 MYC
ENSEMBL:ENSG00000136997 MYC
ENSEMBL_homo_sapiens_GENE:ENSG00000136997.22 MYC
HGNC:7553 MYC
KEGG Gene (Homo sapiens):4609 MYC
Monarch:4609 MYC
NCBI Gene:4609 MYC
OMIM:190080 MYC
UCSC:P01106 MYC
Reference Transcript
RefSeq:NM_002467.4 MYC
Other Identifiers
11745021_a_at
17072669
1827_s_at
1936_s_at
1973_s_at
202431_PM_s_at
202431_s_at
239931_PM_at
239931_at
3115511
3115512
3115513
3115514
3115515
3115516
3115517
3115518
3115519
3115520
3115521
3115522
3115523
3115524
3115525
3115526
3115527
37724_at
4609
69992_at
8148317
A_14_P137636
A_23_P215956
A_24_P178011
A_24_P38363
A_33_P3245163
GE57537
GE85078
GO:0000082
GO:0000122
GO:0000165
GO:0000278
GO:0000785
GO:0000978
GO:0000981
GO:0001046
GO:0001221
GO:0001227
GO:0001228
GO:0001658
GO:0002053
GO:0002376
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006879
GO:0006974
GO:0008284
GO:0009410
GO:0010332
GO:0010468
GO:0010564
GO:0010628
GO:0012501
GO:0023052
GO:0030154
GO:0032200
GO:0032204
GO:0032873
GO:0032986
GO:0032991
GO:0034644
GO:0042802
GO:0043066
GO:0043226
GO:0043280
GO:0044027
GO:0044346
GO:0044877
GO:0045656
GO:0045893
GO:0045944
GO:0046983
GO:0048146
GO:0048147
GO:0048856
GO:0050679
GO:0051276
GO:0051782
GO:0051973
GO:0055065
GO:0060633
GO:0070371
GO:0070848
GO:0070888
GO:0071456
GO:0071466
GO:0071943
GO:0090096
GO:0090571
GO:0098772
GO:0140110
GO:0140297
GO:0140537
GO:1902255
GO:1902895
GO:1904672
GO:1905761
HMNXSV003025638
HMNXSV003038212
Hs.202453.0.A1_3p_at
ILMN_1680618
ILMN_2110908
L00058_at
M13929_s_at
PH_hs_0023009
TC08000749.hg
g12962934_3p_a_at
Participates
as an output of
Estrogen-responsive MYC gene expression (Homo sapiens)
MYC mRNA translation is negatively regulated by miR-34B and C (Homo sapiens)
NOTCH1 PEST domain mutants stimulate MYC transcription (Homo sapiens)
MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA (Homo sapiens)
TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene (Homo sapiens)
NOTCH1 stimulates MYC transcription (Homo sapiens)
MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex (Homo sapiens)
as an input of
MYC binds MAPKAPK5 gene (Homo sapiens)
TFAP2C homodimer binds MYC and KDM5B (Homo sapiens)
MYC binds the NFE2L2 promoter (Homo sapiens)
as a component of
MAPKAPK5 gene:MYC [nucleoplasm] (Homo sapiens)
TFAP2C homodimer:MYC:KDM5B [nucleoplasm] (Homo sapiens)
MYC:MAX [nucleoplasm] (Homo sapiens)
NFE2L2 gene:MYC [nucleoplasm] (Homo sapiens)
as a member of
CLSPN, MYC [nucleoplasm] (Homo sapiens)
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
MYC,MYCN [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PolyUb-MYC [nucleoplasm]
Inferred To
Myc [nucleoplasm]
(Drosophila melanogaster)
Myc [nucleoplasm]
(Mus musculus)
Myc [nucleoplasm]
(Rattus norvegicus)
MYC [nucleoplasm]
(Bos taurus)
MYC [nucleoplasm]
(Canis familiaris)
MYC [nucleoplasm]
(Gallus gallus)
MYC [nucleoplasm]
(Sus scrofa)
mycb [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_002458.2
OpenTargets
ENSG00000136997
HPA
ENSG00000136997-MYC
ZINC - Substances
MYC_HUMAN
GeneCards
P01106
ZINC target
P01106
Ensembl
ENSG00000136997
,
ENST00000652288
,
ENSP00000367207
,
ENST00000377970
,
ENSP00000516744
,
ENSP00000516743
,
ENSP00000516742
,
ENSP00000430235
,
ENSP00000478887
,
ENST00000524013
,
ENSP00000516745
,
ENST00000707116
,
ENST00000621592
,
ENSP00000499105
,
ENST00000707114
,
ENST00000707115
,
ENST00000707113
PRO
P01106
Pharos - Targets
P01106
ZINC - Predictions - Purchasable
MYC_HUMAN
Orphanet
17399
PDB
2OR9
,
7T1Y
,
8J2Q
,
5I4Z
,
5I50
,
1MV0
,
2A93
,
4Y7R
,
6C4U
,
6E16
,
8OTS
,
7T1Z
,
6G6J
,
8OTT
,
1EE4
,
8Q1N
,
6E24
,
1A93
,
6G6K
,
1NKP
,
6G6L
Interactors (148)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61244 MAX
1
MAX [nucleoplasm]
(R-HSA-3006627)
0.982
50
UniProt:Q9Y4A5 TRRAP
1
TRRAP [nucleoplasm]
(R-HSA-3322951)
0.886
8
UniProt:Q969H0 FBXW7
1
FBXW7 [cytosol]
(R-HSA-391304)
0.832
7
UniProt:Q13105 ZBTB17
1
ZBTB17 [nucleoplasm]
(R-HSA-535577)
0.775
9
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.775
20
UniProt:Q96L91 EP400
1
EP400 [nucleoplasm]
(R-HSA-3321987)
0.763
6
UniProt:Q9Y5Q9 GTF3C3
1
GTF3C3 [nucleoplasm]
(R-HSA-83691)
0.75
5
UniProt:Q8N163 CCAR2
2
DBC1 [nucleoplasm]
(R-HSA-3371479)
p-T454-DBC1 [nucleoplasm]
(R-HSA-3371569)
0.749
9
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.731
7
UniProt:Q13526 PIN1
2
PIN1 [cytosol]
(R-HSA-9626823)
PIN1 [nucleoplasm]
(R-HSA-936016)
0.71
5
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.69
4
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.688
5
UniProt:Q15029 EFTUD2
1
EFTUD2 [nucleoplasm]
(R-HSA-71883)
0.677
6
UniProt:P42704 LRPPRC
1
LRPPRC [mitochondrial matrix]
(R-HSA-5336174)
0.669
3
UniProt:O94906 PRPF6
1
PRPF6 [nucleoplasm]
(R-HSA-71881)
0.669
3
UniProt:Q9NTJ3 SMC4
3
SMC4 [nucleoplasm]
(R-HSA-1629795)
p-S-SMC4 [cytosol]
(R-HSA-2529018)
SMC4 [cytosol]
(R-HSA-2517876)
0.669
3
UniProt:P11387 TOP1
2
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
TOP1 [nucleoplasm]
(R-HSA-4641363)
0.669
3
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.666
4
UniProt:Q9UBB4 ATX10
0.666
4
UniProt:P55084 HADHB
1
HADHB [mitochondrial inner membrane]
(R-HSA-77266)
0.643
3
UniProt:P52164
1
Max [nucleoplasm]
(R-RNO-3006627)
0.632
4
UniProt:Q14669 TRIP12
1
TRIP12 [cytosol]
(R-HSA-976046)
0.632
7
UniProt:Q8TAD8 SNIP1
1
SNIP1 [nucleoplasm]
(R-HSA-3222315)
0.625
9
UniProt:O15169 AXIN1
11
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
AXIN1 [cytosol]
(R-HSA-195249)
0.623
10
UniProt:Q62141
1
Sin3b [nucleoplasm]
(R-MMU-349685)
0.616
8
UniProt:O96019 ACTL6A
1
ACTL6A [nucleoplasm]
(R-HSA-2980912)
0.615
3
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.615
3
UniProt:P03204 EBNA6
0.61
11
UniProt:O75182 SIN3B
1
SIN3B [nucleoplasm]
(R-HSA-3006450)
0.607
7
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.602
4
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.597
3
UniProt:O00499-10 BIN1
0.593
3
UniProt:P11802 CDK4
3
CDK4 [cytosol]
(R-HSA-68330)
CDK4 [nucleoplasm]
(R-HSA-113843)
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
0.592
2
UniProt:Q8N3Y1 FBXW8
1
FBXW8 [cytosol]
(R-HSA-976017)
0.567
3
UniProt:P06788 VE7
0.567
5
UniProt:Q13263 TRIM28
3
SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm]
(R-HSA-3782600)
TRIM28 [nucleoplasm]
(R-HSA-974998)
SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm]
(R-HSA-9842867)
0.564
2
UniProt:O95347 SMC2
2
SMC2 [nucleoplasm]
(R-HSA-1629792)
SMC2 [cytosol]
(R-HSA-2517875)
0.564
2
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.564
2
UniProt:Q92922 SMARCC1
1
SMARCC1 [nucleoplasm]
(R-HSA-389257)
0.564
2
UniProt:O00567 NOP56
2
NOP56 [nucleoplasm]
(R-HSA-6790696)
NOP56 [cytosol]
(R-HSA-391293)
0.564
2
UniProt:Q9UHI6 DDX20
2
DDX20 [nucleoplasm]
(R-HSA-191847)
DDX20 [cytosol]
(R-HSA-191838)
0.564
2
UniProt:Q9NRZ9 HELLS
1
HELLS [nucleoplasm]
(R-HSA-9839382)
0.564
2
UniProt:Q13085 ACACA
2
ACACA [cytosol]
(R-HSA-1660609)
Btn-ACACA [cytosol]
(R-HSA-2976730)
0.564
2
UniProt:Q8TEX9 IPO4
0.564
2
UniProt:P17480 UBTF
2
p-UBTF [nucleoplasm]
(R-HSA-76039)
UBTF [nucleoplasm]
(R-HSA-73683)
0.564
2
UniProt:Q9Y678 COPG1
4
COPG1 [endoplasmic reticulum membrane]
(R-HSA-6810960)
COPG1 [Golgi membrane]
(R-HSA-6808747)
COPG1 [transport vesicle]
(R-HSA-6808749)
COPG1 [cytosol]
(R-HSA-199987)
0.564
2
UniProt:P17812 CTPS1
1
CTPS1 [cytosol]
(R-HSA-73536)
0.564
2
UniProt:Q96T76 MMS19
1
MMS19 [cytosol]
(R-HSA-2161121)
0.564
2
UniProt:Q9NTI5 PDS5B
4
PDS5B [cytosol]
(R-HSA-2484800)
PDS5B [chromosome]
(R-HSA-2466361)
PDS5B [chromosome, centromeric region]
(R-HSA-2468263)
PDS5B [nucleoplasm]
(R-HSA-2468051)
0.564
2
UniProt:P35249 RFC4
1
RFC4 [nucleoplasm]
(R-HSA-68429)
0.564
2
UniProt:P30876 POLR2B
1
POLR2B [nucleoplasm]
(R-HSA-63504)
0.564
2
UniProt:Q13576 IQGAP2
3
IQGAP2 [plasma membrane]
(R-HSA-6804811)
IQGAP2 [secretory granule membrane]
(R-HSA-6804779)
IQGAP2 [cytosol]
(R-HSA-5625975)
0.564
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.564
2
UniProt:P56192 MARS1
1
MARS [cytosol]
(R-HSA-379657)
0.564
2
UniProt:Q92974 ARHGEF2
1
ARHGEF2 [cytosol]
(R-HSA-195101)
0.564
2
UniProt:Q8WUM0 NUP133
2
NUP133 [nuclear envelope]
(R-HSA-157743)
NUP133 [cytosol]
(R-HSA-376251)
0.564
2
UniProt:Q07864 POLE
1
POLE [nucleoplasm]
(R-HSA-68473)
0.564
2
UniProt:P52701 MSH6
2
MSH6 L222* [nucleoplasm]
(R-HSA-5632954)
MSH6 [nucleoplasm]
(R-HSA-5357528)
0.564
2
UniProt:Q9GZR7 DDX24
0.564
2
UniProt:Q9HAV4 XPO5
2
XPO5 [cytosol]
(R-HSA-847719)
XPO5 [nucleoplasm]
(R-HSA-847721)
0.564
2
UniProt:Q8N1F7 NUP93
2
NUP93 [nuclear envelope]
(R-HSA-157749)
NUP93 [cytosol]
(R-HSA-9634167)
0.564
2
UniProt:Q3KQU3 MA7D1
0.564
2
UniProt:O75643 SNRNP200
1
SNRNP200 [nucleoplasm]
(R-HSA-71885)
0.564
2
UniProt:P16615 ATP2A2
2
ATP2A2 [platelet dense tubular network membrane]
(R-HSA-427903)
ATP2A2 [endoplasmic reticulum membrane]
(R-HSA-391962)
0.564
2
UniProt:Q96P70 IPO9
0.564
2
UniProt:O60313 OPA1
4
OPA1 [mitochondrial inner membrane]
(R-HSA-5333636)
OPA1(195-960) [mitochondrial inner membrane]
(R-HSA-8867513)
OPA1(88-194) [mitochondrial inner membrane]
(R-HSA-8867509)
OPA1 [mitochondrial inner membrane]
(R-HSA-8867508)
0.564
2
UniProt:P07910 HNRNPC
3
HNRNPC [cytosol]
(R-HSA-9715136)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [nucleoplasm]
(R-HSA-71933)
0.564
2
UniProt:Q9BQG0 MYBBP1A
1
MYBBP1A [nucleoplasm]
(R-HSA-5250650)
0.564
2
UniProt:A5D8W4 A5D8W4
0.556
3
UniProt:P55212 CASP6
5
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(194-293) [cytosol]
(R-HSA-266128)
0.556
3
UniProt:Q13148 TADBP
0.556
6
UniProt:Q01658 DR1
1
DR1 [nucleoplasm]
(R-HSA-3662280)
0.556
3
UniProt:O75400-2 PRPF40A
0.556
3
UniProt:P13473-2 P134732
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
0.556
3
UniProt:Q9Y371 SHLB1
0.556
3
UniProt:Q9Y649 Q9Y649
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:P28329-3 P283293
0.556
3
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.556
3
UniProt:Q00403 GTF2B
1
GTF2B [nucleoplasm]
(R-HSA-65888)
0.556
3
UniProt:P31948 STIP1
1
STIP1 [cytosol]
(R-HSA-443857)
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:P06307 CCK
1
CCK [extracellular region]
(R-HSA-388539)
0.556
3
UniProt:P52292 KPNA2
2
KPNA2 [nucleoplasm]
(R-HSA-206045)
KPNA2 [cytosol]
(R-HSA-205976)
0.547
2
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.547
2
UniProt:Q92616 GCN1
1
GCN1 [cytosol]
(R-HSA-9633010)
0.547
2
UniProt:P17980 PSMC3
5
PSMC3 [secretory granule lumen]
(R-HSA-6800917)
PSMC3 [extracellular region]
(R-HSA-6806496)
PSMC3 [ficolin-1-rich granule lumen]
(R-HSA-6800429)
PSMC3 [nucleoplasm]
(R-HSA-174313)
PSMC3 [cytosol]
(R-HSA-68774)
0.547
2
UniProt:Q8TCG1 CIP2A
0.544
2
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.536
2
UniProt:Q12888 TP53BP1
3
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
TP53BP1 [nucleoplasm]
(R-HSA-61175)
0.536
2
UniProt:P68366 TUBA4A
9
TUBA4A [cytosol]
(R-HSA-191694)
TUBA4A [axonemal microtubule]
(R-HSA-5610443)
TUBA4A [extracellular region]
(R-HSA-350734)
Polyglutamyl-TUBA4A [cytosol]
(R-HSA-8867386)
L-isoglutamyl polyglycyl-TUBA4A [cytosol]
(R-HSA-8867378)
TUBA4A unfolded [cytosol]
(R-HSA-392771)
TUBA4A folding intermediate [cytosol]
(R-HSA-392800)
Ac K40 TUBA4A [axonemal microtubule]
(R-HSA-5624859)
AcK-TUBA4A [cytosol]
(R-HSA-5618318)
0.527
5
UniProt:Q9UKN8 GTF3C4
1
GTF3C4 [nucleoplasm]
(R-HSA-83689)
0.527
2
UniProt:P56134 ATP5MF
1
ATP5MF [mitochondrial inner membrane]
(R-HSA-50516)
0.527
2
UniProt:Q15678 PTPN14
1
PTPN14 [nucleoplasm]
(R-HSA-9008917)
0.527
2
UniProt:P36542 ATP5F1C
1
ATP5F1C [mitochondrial matrix]
(R-HSA-164577)
0.527
2
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.527
3
UniProt:P62191 PSMC1
2
PSMC1 [nucleoplasm]
(R-HSA-174338)
PSMC1 [cytosol]
(R-HSA-68768)
0.527
2
UniProt:P02545 LMNA
3
LMNA(1-646) [nuclear envelope]
(R-HSA-535479)
LMNA(1-567)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802399)
LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802537)
0.527
3
UniProt:Q6PIV2 FOXR1
0.527
3
UniProt:Q9BRK5 CAB45
0.527
2
UniProt:Q14697 GANAB
1
GANAB [endoplasmic reticulum lumen]
(R-HSA-532674)
0.527
2
UniProt:O60762 DPM1
4
DPM1 R92G [endoplasmic reticulum membrane]
(R-HSA-4717370)
DPM1 Q210Rfs*4 [endoplasmic reticulum membrane]
(R-HSA-4717361)
DPM1 G111Lfs*45 [endoplasmic reticulum membrane]
(R-HSA-4717383)
DPM1 [endoplasmic reticulum membrane]
(R-HSA-162865)
0.527
2
UniProt:Q9Y6M1 IGF2BP2
1
IGF2BP2 [cytosol]
(R-HSA-428302)
0.527
2
UniProt:P26641 EEF1G
3
EEF1G [cytosol]
(R-HSA-156925)
EEF1G(1-343)-ALK(1106-1620) fusion [cytosol]
(R-HSA-9710839)
EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol]
(R-HSA-9710850)
0.527
2
IntAct:EBI-6620396 PYR1
0.527
2
UniProt:Q15233 NONO
0.527
2
UniProt:Q6PJQ5 FOXR2
0.527
2
UniProt:O75306 NDUFS2
1
NDUFS2 [mitochondrial matrix]
(R-HSA-6788520)
0.527
2
UniProt:P0C0S5 H2AZ1
1
H2AFZ [extracellular region]
(R-HSA-977575)
0.527
2
UniProt:P25786 PSMA1
2
PSMA1 [nucleoplasm]
(R-HSA-174333)
PSMA1 [cytosol]
(R-HSA-68724)
0.527
2
UniProt:P25788 PSMA3
2
PSMA3 [nucleoplasm]
(R-HSA-174323)
PSMA3 [cytosol]
(R-HSA-68728)
0.527
2
UniProt:Q9Y6N5 SQRDL
3
2xHC-SQRDL(1-450) [mitochondrial inner membrane]
(R-HSA-1614613)
SQRDL(1-450) [mitochondrial inner membrane]
(R-HSA-1614646)
CysS-SQRDL(1-450) [mitochondrial inner membrane]
(R-HSA-1614576)
0.527
2
UniProt:O43823 AKAP8
0.527
2
UniProt:P53597 SUCLG1
1
SUCLG1 [mitochondrial matrix]
(R-HSA-156623)
0.527
2
UniProt:O60264 SMARCA5
1
SMARCA5 [nucleoplasm]
(R-HSA-417140)
0.527
2
UniProt:P24928 POLR2A
7
p-S2,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6814543)
p-S5,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6810226)
p-S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-77100)
Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-6781855)
p-3S-POLR2A [nucleoplasm]
(R-HSA-6797701)
p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-113420)
POLR2A [nucleoplasm]
(R-HSA-63502)
0.527
4
UniProt:P78346 RPP30
1
RPP30 [nucleoplasm]
(R-HSA-5696779)
0.527
2
UniProt:Q13200 PSMD2
5
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [cytosol]
(R-HSA-68796)
0.527
3
UniProt:Q8N6T7 SIRT6
1
SIRT6 [nucleoplasm]
(R-HSA-5685963)
0.524
3
UniProt:O43524 FOXO3
11
p-S215 FOXO3 [nucleoplasm]
(R-HSA-5687010)
p-S215 FOXO3 [cytosol]
(R-HSA-5687014)
FOXO3 [cytosol]
(R-HSA-5687032)
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
(R-HSA-8870627)
p-S43,S173,S294,S325-FOXO3 [cytosol]
(R-HSA-8870560)
FOXO3(?-673) [mitochondrial matrix]
(R-HSA-9841824)
Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix]
(R-HSA-9841849)
Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]
(R-HSA-9620514)
p-T32,S253,S315-FOXO3 [cytosol]
(R-HSA-9614413)
p-T32,S253,S315-FOXO3 [nucleoplasm]
(R-HSA-199289)
FOXO3 [nucleoplasm]
(R-HSA-199305)
0.524
3
UniProt:Q86XR8 CEP57
1
CEP57 [cytosol]
(R-HSA-380271)
0.524
3
UniProt:Q15059 BRD3
0.524
3
UniProt:P04020 VE7
0.508
2
UniProt:A9UHW6 MI4GD
0.508
2
UniProt:P03129 VE7
0.508
2
UniProt:O00499-11 BIN1
0.508
2
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.499
3
UniProt:P03070 LT
0.499
2
UniProt:Q14839 CHD4
1
CHD4 [nucleoplasm]
(R-HSA-3702078)
0.499
2
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.499
4
IntAct:EBI-1648030 CDK4
0.499
2
UniProt:O75928 PIAS2
1
PIAS2 [nucleoplasm]
(R-HSA-2993787)
0.499
4
UniProt:O95619 YEATS4
1
YEATS4 [nucleoplasm]
(R-HSA-3322940)
0.483
2
UniProt:Q03164 KMT2A
6
KMT2A [cytosol]
(R-HSA-9818584)
KMT2A(2719-3969) [cytosol]
(R-HSA-9818590)
KMT2A(1-2718) [cytosol]
(R-HSA-9818597)
KMT2A [nucleoplasm]
(R-HSA-1183223)
KMT2A(1-2718) [nucleoplasm]
(R-HSA-9818591)
KMT2A(2719-3969) [nucleoplasm]
(R-HSA-9818593)
0.483
2
UniProt:P04843 RPN1
1
RPN1 [endoplasmic reticulum membrane]
(R-HSA-264994)
0.483
2
UniProt:Q9NV56 MRGBP
1
MRGBP [nucleoplasm]
(R-HSA-3322953)
0.483
2
UniProt:P40939 HADHA
1
HADHA [mitochondrial inner membrane]
(R-HSA-77264)
0.483
2
UniProt:Q9H2F5 EPC1
1
EPC1 [nucleoplasm]
(R-HSA-3321978)
0.483
2
UniProt:P58317 ZN121
0.482
2
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.463
3
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.463
3
UniProt:P12956 XRCC6
5
XRCC6 [secretory granule lumen]
(R-HSA-6801312)
XRCC6 [extracellular region]
(R-HSA-6806444)
XRCC6 [ficolin-1-rich granule lumen]
(R-HSA-6801300)
XRCC6 [cytosol]
(R-HSA-3134813)
XRCC6 [nucleoplasm]
(R-HSA-58272)
0.462
3
UniProt:O15379 HDAC3
2
HDAC3 [nucleoplasm]
(R-HSA-442464)
Unfolded HDAC3 [cytosol]
(R-HSA-6813777)
0.462
6
UniProt:Q15022 SUZ12
2
SUZ12 [nucleoplasm]
(R-HSA-212217)
monoSUMO1-K75-SUZ12 [nucleoplasm]
(R-HSA-4615932)
0.462
4
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.462
2
UniProt:Q9DH70 Q9DH70
0.462
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text