trehalose + H2O => 2 D-glucose

Stable Identifier
Reaction [transition]
Homo sapiens
Digestion of trehalose to yield glucose
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Extracellular trehalose, a disaccharide, is cleaved by trehalase associated with the plasma membrane to yield two molecules of glucose. Trehalase has been purified to homogeneity from rabbit intestine and shown to be a monomer attached to the plasma membrane by a GPI anchor (Galand 1984; Ruf et al. 1990). A human cDNA encoding a closely homologous protein has been cloned and its protein product has been shown to have trehalase activity in vitro (Ishihara et al. 1997). The human enzyme has not been characterized further, and so both the posttranslational modifications of the human enzyme and its activity in vivo have been inferred from the properties of the well studied rabbit enzyme.

Trehalase deficiency has been described in two isolated cases in Europe (Bergoz 1971; Madzarovovà-Nohejlova 1973) and at high frequency in a population of Greenland natives (Gudmand-Hoyer et al. 1988) but molecular defects responsible for the deficiency have not yet been described so it is not annotated in Reactome.

Literature References
PubMed ID Title Journal Year
5104075 Trehalose malabsorption causing intolerance to mushrooms. Report of a probable case

Bergoz, R

Gastroenterology 1971
1697585 Rabbit small intestinal trehalase. Purification, cDNA cloning, expression, and verification of glycosylphosphatidylinositol anchoring.

von Kieckebusch, A, Mantei, N, Semenza, G, James, P, Ruf, J, Galand, G, Wacker, H, Maffia, M, Seiler, P

J Biol Chem 1990
9427547 Molecular cloning, sequencing and expression of cDNA encoding human trehalase

Kobayashi, Y, Ishihara, R, Kino, M, Sasai-Takedatsu, M, Tokunaga, R, Taketani, S

Gene 1997
6466686 Purification and characterization of kidney and intestinal brush-border membrane trehalases from the rabbit

Galand, G

Biochim Biophys Acta 1984
4737205 Trehalase deficiency in a family

Madzarovovà-Nohejlova, J

Gastroenterology 1973
3227291 Trehalase deficiency in Greenland

Gudmand-Høyer, E, Skovbjerg, H, Madsen, PR, Fenger, HJ, Kern-Hansen, P

Scand. J. Gastroenterol. 1988
Catalyst Activity

alpha,alpha-trehalase activity of N-seryl-glycosylphosphatidylinositolethanolamine-TREH [plasma membrane]

Inferred From
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