Reactome | HMOX2 [endoplasmic reticulum membrane]

HMOX2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-189391

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Heme oxygenase 2, HO2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P30519 HMOX2

Gene Names

HMOX2, HO2

Chain

initiator methionine:1, chain:2-316, chain:2-295

Reference Genes

BioGPS Gene:3163 HMOX2

COSMIC (genes):HMOX2 HMOX2

CTD Gene:3163 HMOX2

dbSNP Gene:3163 HMOX2

ENSEMBL:ENSG00000103415 HMOX2

ENSEMBL:ENSG00000103415.12 HMOX2

ENSEMBL:ENSG00000277424.4 HMOX2

HGNC:5014 HMOX2

KEGG Gene (Homo sapiens):3163 HMOX2

Monarch:3163 HMOX2

NCBI Gene:3163 HMOX2

OMIM:141251 HMOX2

UCSC:P30519 HMOX2

Reference Transcript

Other Identifiers

11729615_a_at

11755424_a_at

16815528

218120_PM_s_at

218120_s_at

218121_PM_at

218121_at

3163

3646200

3646202

3646204

3646205

3646206

3646207

3646211

3646212

3646213

3646214

3646216

3646217

3646219

3646220

3646221

3646222

3646223

37916_at

64632_at

7992987

A_14_P200412

A_23_P100501

A_24_P381945

GE80151

GO:0001666

GO:0003824

GO:0004392

GO:0005515

GO:0005783

GO:0005789

GO:0005886

GO:0006788

GO:0006979

GO:0016020

GO:0016491

GO:0020037

GO:0031410

GO:0035579

GO:0042167

GO:0043226

GO:0043231

GO:0046872

HMNXSV003058246

ILMN_1658807

PH_hs_0014732

PH_hs_0035751

S34389_at

TC16000131.hg

g416226_3p_a_at

g8051607_3p_at

Participates

as a member of

HMOX1 dimer, HMOX2 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

HMOX2 [plasma membrane]

HMOX2 [specific granule membrane]

Inferred To

hmox2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

HMOX2 [endoplasmic reticulum membrane] (Bos taurus)

HMOX2 [endoplasmic reticulum membrane] (Canis familiaris)

HMOX2 [endoplasmic reticulum membrane] (Danio rerio)

HMOX2 [endoplasmic reticulum membrane] (Gallus gallus)

HMOX2 [endoplasmic reticulum membrane] (Mus musculus)

HMOX2 [endoplasmic reticulum membrane] (Rattus norvegicus)

HMOX2 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_001273196.1, NP_001273200.1, NP_001120676.1, NP_002125.3, XP_016878685.1, NP_001120677.1, XP_016878686.1, NP_001273198.1, NP_001273199.1, NP_001273197.1, NP_001120678.1

Guide to Pharmacology - Targets

1442

OpenTargets

ENSG00000103415

HPA

ENSG00000103415-HMOX2

GeneCards

P30519

Ensembl

ENSP00000385100, ENST00000612525, ENSP00000487673, ENSP00000394103, ENST00000414777, ENST00000621065, ENST00000615778, ENSP00000459214, ENST00000619913, ENSP00000219700, ENSP00000484423, ENST00000632458, ENSP00000484467, ENST00000619528, ENSP00000483319, ENSP00000481811, ENST00000575120, ENSP00000484422, ENSP00000481295, ENST00000458134, ENST00000219700, ENST00000631677, ENST00000633319, ENSP00000478785, ENST00000570646, ENSP00000381595, ENSP00000460926, ENST00000406590, ENST00000622146, ENSG00000277424, ENST00000620445, ENSG00000103415, ENSP00000488769, ENSP00000391637, ENSP00000488579, ENST00000398595, ENSP00000488880, ENST00000631540

PRO

P30519

Pharos - Targets

P30519

HMDB Protein

HMDBP00151

PDB

2Q32, 2QPP, 5UC9, 5UC8, 2RGZ, 5UCA, 4WMH

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IWU4 SLC30A8	2	SLC30A8 [Golgi membrane] (R-HSA-9817561) SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:O95470 SGPL1	1	PXLP-SGPL1 [endoplasmic reticulum membrane] (R-HSA-428661)	0.556	3
UniProt:Q14032 BAAT	2	BAAT [cytosol] (R-HSA-159392) BAAT [peroxisomal matrix] (R-HSA-193517)	0.556	3
UniProt:P21579 SYT1	7	SYT1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869113) SYT1 [synaptic vesicle membrane] (R-HSA-194789) SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-210536) SYT1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-372514) SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917741) SYT1 [plasma membrane] (R-HSA-168786) SYT1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372508)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q9Y2X7 GIT1	2	p-Y383-GIT1 [cytosol] (R-HSA-3928463) GIT1 [cytosol] (R-HSA-430326)	0.553	2
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.527	2

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