Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HMOX1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-189395
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Heme oxygenase 1, HO1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
HMOX1 dimer, HMOX2 [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 [endoplasmic reticulum membrane] (Homo sapiens)
Regulation of HMOX1 expression and activity (Homo sapiens)
HM13 cleaves HMOX1 dimer (Homo sapiens)
HMOX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Homo sapiens)
HMOX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 gene produces HMOX1 dimer (Homo sapiens)
HMOX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 [endoplasmic reticulum membrane] (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
NFE2L2-dependent HMOX1 gene expression (Homo sapiens)
HMOX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 [endoplasmic reticulum membrane] (Homo sapiens)
Heme signaling (Homo sapiens)
HMOX1 gene produces HMOX1 dimer (Homo sapiens)
HMOX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 [endoplasmic reticulum membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of HMOX1 (Homo sapiens)
HMOX1 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of porphyrins (Homo sapiens)
Heme degradation (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
HMOX1 dimer, HMOX2 [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 [endoplasmic reticulum membrane] (Homo sapiens)
Protein localization (Homo sapiens)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (Homo sapiens)
Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane (Homo sapiens)
Tail-anchored proteins [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 [endoplasmic reticulum membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
HMOX1 dimer, HMOX2 [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
HMOX1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09601 HMOX1
Gene Names
HMOX1, HO, HO1
Chain
chain:1-288, chain:1-265
Reference Genes
BioGPS Gene:3162 HMOX1
COSMIC (genes):HMOX1 HMOX1
CTD Gene:3162 HMOX1
dbSNP Gene:3162 HMOX1
ENSEMBL:ENSG00000100292 HMOX1
ENSEMBL_homo_sapiens_GENE:ENSG00000100292.18 HMOX1
HGNC:5013 HMOX1
KEGG Gene (Homo sapiens):3162 HMOX1
Monarch:3162 HMOX1
NCBI Gene:3162 HMOX1
OMIM:141250 HMOX1
Reference Transcript
RefSeq:NM_002133.2 HMOX1
Other Identifiers
11716939_a_at
11753445_a_at
11753446_x_at
16929562
203665_PM_at
203665_at
3162
33802_at
3944138
3944139
3944140
3944141
3944142
3944144
3944145
3944146
8072678
A_23_P120883
GE61857
GO:0001525
GO:0001935
GO:0002246
GO:0002376
GO:0002686
GO:0003012
GO:0003824
GO:0004392
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005739
GO:0005741
GO:0005783
GO:0005789
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006788
GO:0006879
GO:0006914
GO:0006915
GO:0006954
GO:0006979
GO:0012501
GO:0014806
GO:0016020
GO:0016236
GO:0016239
GO:0016242
GO:0016491
GO:0019899
GO:0020037
GO:0023052
GO:0032722
GO:0034101
GO:0034383
GO:0034605
GO:0035094
GO:0035556
GO:0042060
GO:0042167
GO:0042168
GO:0042542
GO:0042802
GO:0042803
GO:0043123
GO:0043226
GO:0045765
GO:0045766
GO:0046872
GO:0048471
GO:0048661
GO:0048662
GO:0048856
GO:0048870
GO:0055065
GO:0060586
GO:0071243
GO:0071276
GO:0071456
GO:0072719
GO:0090050
GO:1902042
GO:1903589
GO:1904019
GO:1904037
HMNXSV003008800
ILMN_1800512
PH_hs_0011943
TC22000259.hg
TC22001089.hg
X06985_at
g4504436_3p_at
p33878
Participates
as a member of
Tail-anchored proteins [endoplasmic reticulum membrane] (Homo sapiens)
as an output of
Expression of HMOX1 (Homo sapiens)
as a component of
HMOX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
HMOX1 [nucleoplasm]
HMOX1 [mitochondrial outer membrane]
HMOX1 [cytosol]
Inferred To
hmox1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
HMOX1 [endoplasmic reticulum membrane]
(Bos taurus)
HMOX1 [endoplasmic reticulum membrane]
(Canis familiaris)
HMOX1 [endoplasmic reticulum membrane]
(Danio rerio)
HMOX1 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
HMOX1 [endoplasmic reticulum membrane]
(Gallus gallus)
HMOX1 [endoplasmic reticulum membrane]
(Mus musculus)
HMOX1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
HMOX1 [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
RefSeq
NP_002124.1
Guide to Pharmacology - Targets
1441
OpenTargets
ENSG00000100292
ZINC - Substances
HMOX1_HUMAN
ZINC target
P09601
PRO
P09601
PDB
3HOK
,
1OZL
,
1OZE
,
1NI6
,
5BTQ
,
1T5P
,
1S8C
,
1N45
,
1XK3
,
1XK2
,
3TGM
,
1XK1
,
6EHA
,
1TWR
,
1N3U
,
1XJZ
,
4WD4
,
1XK0
,
3CZY
,
1OZW
,
1OZR
,
1OYK
,
1TWN
,
1OYL
,
1S13
,
3K4F
GeneCards
P09601
HPA
ENSG00000100292-HMOX1
Ensembl
ENSP00000216117
,
ENST00000216117
,
ENSG00000100292
Pharos - Targets
P09601
ZINC - Predictions - Purchasable
HMOX1_HUMAN
Orphanet
24601
HMDB Protein
HMDBP00198
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC3 3a
9
O-glycosyl 3a [virion membrane]
(R-COV-9694395)
O-glycosyl 3a [endocytic vesicle membrane]
(R-COV-9694729)
O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694386)
GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694658)
3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694716)
3a [endoplasmic reticulum lumen]
(R-COV-9694584)
O-glycosyl 3a [endolysosome membrane]
(R-COV-9754541)
O-glycosyl 3a [plasma membrane]
(R-COV-9694433)
O-glycosyl 3a [extracellular region]
(R-COV-9694387)
0.738
4
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.601
4
UniProt:P11912 CD79A
2
p-Y188,Y199-CD79A [plasma membrane]
(R-HSA-983539)
CD79A [plasma membrane]
(R-HSA-197154)
0.556
3
UniProt:Q96KR6 F210B
0.556
3
UniProt:Q8TBP5 F174A
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:P49447 CY561
0.556
3
UniProt:Q13113 PDZ1I
0.556
3
UniProt:Q9NUH8 TM14B
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:O60669 SLC16A7
1
SLC16A7 [plasma membrane]
(R-HSA-373955)
0.556
3
UniProt:Q9BUF7-2 CRB3
0.556
3
UniProt:Q9BY50 SEC11C
1
SEC11C [endoplasmic reticulum membrane]
(R-HSA-265065)
0.556
3
UniProt:Q96MV1 TLCD4
0.556
3
UniProt:Q7Z7G2 CPLX4
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:Q9GZR5 ELOVL4
1
ELOVL4 [endoplasmic reticulum membrane]
(R-HSA-548705)
0.556
3
UniProt:Q8N5M9 JAGN1
0.556
3
IntAct:EBI-22344578 CCSB ORF ID
0.556
3
UniProt:O75208 COQ9
1
COQ9 [mitochondrial inner membrane]
(R-HSA-8932994)
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:Q96DZ7 T4S19
0.556
3
UniProt:Q53TN4 CYBRD1
1
CYBRD1 [plasma membrane]
(R-HSA-917788)
0.556
3
UniProt:Q9NYP7 ELOVL5
1
ELOVL5 [endoplasmic reticulum membrane]
(R-HSA-548679)
0.556
3
UniProt:Q15800 MSMO1
1
MSMO1 [endoplasmic reticulum membrane]
(R-HSA-194648)
0.556
3
UniProt:Q9H5J4 ELOVL6
1
ELOVL6 [endoplasmic reticulum membrane]
(R-HSA-548680)
0.556
3
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
UniProt:Q9Y6I9 TEX264
2
TEX264 [extracellular region]
(R-HSA-8863002)
TEX264 [platelet alpha granule lumen]
(R-HSA-8863000)
0.527
3
UniProt:Q9BZ11 ADAM33
1
ADAM33 [plasma membrane]
(R-HSA-708324)
0.527
2
UniProt:Q9P296 C5AR2
1
C5AR2 [plasma membrane]
(R-HSA-964798)
0.527
2
UniProt:Q9NU19 TB22B
0.527
2
UniProt:Q16880 UGT8
1
UGT8 [endoplasmic reticulum membrane]
(R-HSA-9844570)
0.527
3
UniProt:Q9Y5M8 SRPRB
1
SRPRB [endoplasmic reticulum membrane]
(R-HSA-265002)
0.527
2
UniProt:Q9NUX5 POT1
1
POT1 [nucleoplasm]
(R-HSA-174890)
0.508
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text