Reactome | UROD [cytosol]

UROD [cytosol]

Stable Identifier

R-HSA-189427

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Uroporphyrinogen III decarboxylase, DCUP_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P06132 UROD

Gene Names

UROD

Chain

chain:1-367

Reference Genes

BioGPS Gene:7389 UROD

COSMIC (genes):UROD UROD

CTD Gene:7389 UROD

dbSNP Gene:7389 UROD

ENSEMBL:ENSG00000126088 UROD

HGNC:12591 UROD

KEGG:hsa:7389 UROD

Monarch:7389 UROD

NCBI Gene:7389 UROD

OMIM:613521 UROD

UCSC:P06132 UROD

Reference Transcript

RefSeq:NM_000374.4 UROD

Other Identifiers

11748578_x_at

11756593_a_at

11756594_x_at

11757384_x_at

11760949_a_at

11760950_x_at

16664048

208970_PM_s_at

208970_s_at

208971_PM_at

208971_at

222074_PM_at

222074_at

2334255

2334280

2334281

2334282

2334283

2334284

2334285

2334286

2334287

2334288

2334289

2334290

2334291

2334292

2334293

2334294

2334295

2334296

2334297

2334298

2334299

2334300

2334301

2334302

2334303

37667_at

61107_at

64614_at

7389

7901073

A_14_P125373

A_14_P200853

A_23_P63050

GE54801

GO:0003824

GO:0004853

GO:0005515

GO:0005654

GO:0005737

GO:0005829

GO:0006778

GO:0006779

GO:0006782

GO:0006783

GO:0006784

GO:0006785

GO:0006787

GO:0016829

GO:0016831

GO:0042168

GO:0048034

HMNXSV003025738

ILMN_1740742

M14016_at

M60891_s_at

PH_hs_0004534

TC01000569.hg

TC01004350.hg

g340180_3p_a_at

Participates

as a component of

2xUROD [cytosol] (Homo sapiens)

Inferred To

UROD [cytosol] (Bos taurus)

UROD [cytosol] (Canis familiaris)

UROD [cytosol] (Danio rerio)

UROD [cytosol] (Dictyostelium discoideum)

UROD [cytosol] (Drosophila melanogaster)

UROD [cytosol] (Gallus gallus)

UROD [cytosol] (Mus musculus)

UROD [cytosol] (Plasmodium falciparum)

UROD [cytosol] (Rattus norvegicus)

UROD [cytosol] (Saccharomyces cerevisiae)

UROD [cytosol] (Schizosaccharomyces pombe)

UROD [cytosol] (Sus scrofa)

urod [cytosol] (Xenopus tropicalis)

Cross References

ENSEMBL

ENSP00000246337, ENST00000246337

OpenTargets

ENSG00000126088

IntEnz

4.1.1.37

HPA

ENSG00000126088-UROD

PRO

P06132

Pharos - Targets

P06132

GlyGen

P06132

Orphanet

UROD

HMDB Protein

HMDBP00250

PDB

3GVR, 3GW3, 1R3Y, 1R3S, 1R3T, 1R3W, 1R3V, 3GVV, 2Q6Z, 1JPK, 1URO, 1R3R, 1JPI, 1JPH, 1R3Q, 3GW0, 3GVW, 3GVQ, 2Q71

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2

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