Reactome | UROD [cytosol]

UROD [cytosol]

Stable Identifier

R-HSA-189427

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Uroporphyrinogen III decarboxylase, DCUP_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P06132 UROD

Gene Names

UROD

Chain

chain:1-367

Reference Genes

BioGPS Gene:7389 UROD

COSMIC (genes):UROD UROD

CTD Gene:7389 UROD

dbSNP Gene:7389 UROD

ENSEMBL:ENSG00000126088 UROD

ENSEMBL:ENSG00000126088.14 UROD

HGNC:12591 UROD

KEGG Gene (Homo sapiens):7389 UROD

Monarch:7389 UROD

NCBI Gene:7389 UROD

OMIM:613521 UROD

UCSC:P06132 UROD

Reference Transcript

RefSeq:NM_000374.4 UROD

Other Identifiers

11748578_x_at

11756593_a_at

11756594_x_at

11757384_x_at

11760950_x_at

208970_PM_s_at

208970_s_at

208971_PM_at

208971_at

2334283

2334284

2334286

2334288

2334291

2334293

2334294

2334296

2334298

2334301

2334302

2334303

37667_at

7389

7901073

A_14_P200853

GE54801

GO:0003824

GO:0004853

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006778

GO:0006779

GO:0006782

GO:0006783

GO:0006787

GO:0016829

GO:0016831

GO:0042168

GO:0043226

M60891_s_at

PH_hs_0004534

TC01004350.hg

g340180_3p_a_at

Participates

as a component of

2xUROD [cytosol] (Homo sapiens)

Inferred To

UROD [cytosol] (Bos taurus)

UROD [cytosol] (Canis familiaris)

UROD [cytosol] (Danio rerio)

UROD [cytosol] (Dictyostelium discoideum)

UROD [cytosol] (Drosophila melanogaster)

UROD [cytosol] (Gallus gallus)

UROD [cytosol] (Mus musculus)

UROD [cytosol] (Plasmodium falciparum)

UROD [cytosol] (Rattus norvegicus)

UROD [cytosol] (Saccharomyces cerevisiae)

UROD [cytosol] (Schizosaccharomyces pombe)

UROD [cytosol] (Sus scrofa)

urod [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_000365.3

OpenTargets

ENSG00000126088

GeneCards

P06132

HPA

ENSG00000126088-UROD

Ensembl

ENSG00000126088, ENST00000246337, ENSP00000246337

PRO

P06132

Pharos - Targets

P06132

Orphanet

15698

HMDB Protein

HMDBP00250

PDB

1JPH, 1URO, 3GVV, 1JPK, 1R3S, 3GVQ, 1R3Y, 2Q71, 1R3Q, 1R3V, 2Q6Z, 3GW0, 1JPI, 3GVW, 3GVR, 1R3R, 1R3W, 3GW3, 1R3T

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2

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