Reactome | FGF19 [extracellular region]

FGF19 [extracellular region]

Stable Identifier

R-HSA-189888

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Fibroblast growth factor-19, FGFJ_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P31749 AKT1

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR4 (Homo sapiens)
      - FGFR4 ligand binding and activation (Homo sapiens)
        
        betaKlotho-mediated ligand binding (Homo sapiens)
        
        FGFR4 binds HS:KLB:FGF19 (Homo sapiens)
        
        FGF19 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95750 FGF19

Gene Names

FGF19, UNQ334/PRO533

Chain

signal peptide:1-24, chain:25-216

Reference Genes

BioGPS Gene:9965 FGF19

COSMIC (genes):FGF19 FGF19

CTD Gene:9965 FGF19

dbSNP Gene:9965 FGF19

ENSEMBL:ENSG00000162344 FGF19

HGNC:3675 FGF19

KEGG:hsa:9965 FGF19

Monarch:9965 FGF19

NCBI Gene:9965 FGF19

OMIM:603891 FGF19

UCSC:O95750 FGF19

Reference Transcript

RefSeq:NM_005117.3 FGF19

Other Identifiers

11731165_at

16741393

223761_PM_at

223761_at

3380128

3380129

3380130

3380131

3380132

3380133

3380134

3380138

3380139

3380140

48270_at

7950023

9965

A_23_P427587

A_23_P52714

GE80672

GO:0001755

GO:0001934

GO:0005104

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0007399

GO:0007507

GO:0008083

GO:0008284

GO:0008543

GO:0009617

GO:0010629

GO:0022008

GO:0030154

GO:0030334

GO:0043410

GO:0045471

GO:0046326

GO:0046330

GO:0048018

GO:0048856

GO:0048870

GO:0070374

GO:0070858

GO:0098772

HMNXSV003008439

ILMN_1760909

PH_hs_0013216

TC11002018.hg

g5668600_3p_at

g5668600_3p_x_at

Participates

as an input of

FGFR4 binds HS:KLB:FGF19 (Homo sapiens)

as a component of

as a member of

FGFR4-binding FGFs [extracellular region] (Homo sapiens)

Inferred To

Fgf19 [extracellular region] (Rattus norvegicus)

FGF19 [extracellular region] (Bos taurus)

FGF19 [extracellular region] (Canis familiaris)

FGF19 [extracellular region] (Gallus gallus)

FGF19 [extracellular region] (Sus scrofa)

fgf19 [extracellular region] (Danio rerio)

fgf19 [extracellular region] (Xenopus tropicalis)

Fgf15 [extracellular region] (Mus musculus)

bnl [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_005108.1

ENSEMBL

ENSP00000294312, ENSG00000162344, ENST00000294312

OpenTargets

ENSG00000162344

GeneCards

FGF19

HPA

ENSG00000162344-FGF19

PRO

O95750

Pharos - Targets

O95750

HMDB Protein

HMDBP12677

PDB

2P23, 6NFJ, 1PWA, 6KTR

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.471	2

Cite Us!