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FGF23(25-251) [extracellular region]
Stable Identifier
R-HSA-189891
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
FGF23, Fibroblast growth factor-23, FGFN_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Downstream signaling of activated FGFR1 (Homo sapiens)
Activated FGFR1 binds FLRT1,2,3 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:FLRT [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
FRS-mediated FGFR1 signaling (Homo sapiens)
Activated FGFR1 binds FRS2 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1 binds FRS3 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1 phosphorylates FRS2 (Homo sapiens)
Activated FGFR1:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1 phosphorylates FRS3 (Homo sapiens)
Activated FGFR1:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS bind to PPTN11 (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Homo sapiens)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
PI-3K cascade:FGFR1 (Homo sapiens)
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Phospholipase C-mediated cascade: FGFR1 (Homo sapiens)
Activated FGFR1 binds PLCG1 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
activated FGFR1:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1 phosphorylates PLCG1 (Homo sapiens)
activated FGFR1:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
p-4Y-PLCG1 dissociates from activated FGFR1 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
SHC-mediated cascade:FGFR1 (Homo sapiens)
Activated FGFR1 binds SHC1 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1 phosphorylates SHC1 (Homo sapiens)
Activated FGFR1:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
FGFR1 ligand binding and activation (Homo sapiens)
FGFR1c and Klotho ligand binding and activation (Homo sapiens)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
FGFR1c binds to Klotho-bound FGF23 (Homo sapiens)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Negative regulation of FGFR1 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Homo sapiens)
Activated FGFR1:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
CBL ubiquitinates FRS2 and FGFR1 (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
FGF23(25-251) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9GZV9 FGF23
Gene Names
FGF23, HYPF, UNQ3027/PRO9828
Chain
signal peptide:1-24, chain:25-251, chain:25-179, chain:180-251
Reference Genes
BioGPS Gene:8074 FGF23
COSMIC (genes):FGF23 FGF23
CTD Gene:8074 FGF23
dbSNP Gene:8074 FGF23
ENSEMBL:ENSG00000118972 FGF23
HGNC:3680 FGF23
KEGG:hsa:8074 FGF23
Monarch:8074 FGF23
NCBI Gene:8074 FGF23
OMIM:605380 FGF23
UCSC:Q9GZV9 FGF23
Reference Transcript
RefSeq:NM_020638.2 FGF23
Other Identifiers
11738379_at
11738380_at
11738381_at
16760148
221166_PM_at
221166_at
3441169
3441170
3441171
3441172
3441173
3441174
3441175
7960397
8074
A_23_P117095
GE82551
GO:0000165
GO:0005104
GO:0005105
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005788
GO:0005796
GO:0006355
GO:0006629
GO:0006766
GO:0008083
GO:0008284
GO:0008543
GO:0009887
GO:0010628
GO:0010966
GO:0010980
GO:0030154
GO:0030334
GO:0030500
GO:0030502
GO:0030643
GO:0032026
GO:0042359
GO:0042369
GO:0043410
GO:0044320
GO:0045668
GO:0045893
GO:0046888
GO:0048018
GO:0055062
GO:0055074
GO:0070371
GO:0070374
GO:0071305
GO:0071354
GO:0071374
GO:0090080
GO:0098772
GO:1904383
HMNXSV003016648
ILMN_1696488
ILMN_1869676
ILMN_2071316
PH_hs_0014821
TC12001120.hg
g10190673_3p_at
Participates
as a component of
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-FGF23 [endoplasmic reticulum lumen]
FGF23 [endoplasmic reticulum lumen]
FGF23(25-251) [Golgi lumen]
GalNAc-T178-FGF23(25-251) [Golgi lumen]
GalNAc-T178-FGF23(25-251) [extracellular region]
Inferred To
Fgf23 [extracellular region]
(Mus musculus)
Fgf23 [extracellular region]
(Rattus norvegicus)
Homologues of FGF23(25-251) [extracellular region]
(Xenopus tropicalis)
fgf23 [extracellular region]
(Danio rerio)
fgf23 [extracellular region]
(Xenopus tropicalis)
fgf23.2 [extracellular region]
(Xenopus tropicalis)
FGF8B [extracellular region]
(Canis familiaris)
FGF23 [extracellular region]
(Bos taurus)
FGF23 [extracellular region]
(Gallus gallus)
FGF23 [extracellular region]
(Sus scrofa)
bnl [extracellular region]
(Drosophila melanogaster)
egl-17 [extracellular region]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_065689.1
ENSEMBL
ENSP00000237837
,
ENST00000237837
OpenTargets
ENSG00000118972
HPA
ENSG00000118972-FGF23
PRO
Q9GZV9
Pharos - Targets
Q9GZV9
GlyGen
Q9GZV9
Orphanet
FGF23
HMDB Protein
HMDBP02741
PDB
6S22
,
7YSU
,
7YSW
,
7YSH
,
2P39
,
5W21
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O35082
2
Kl [plasma membrane]
(R-MMU-190198)
Kl [extracellular region]
(R-MMU-190201)
0.733
5
UniProt:P11362 FGFR1
9
FGFR1 [plasma membrane]
(R-HSA-9756433)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
0.544
2
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