FGFR3 ligand binding and activation

Stable Identifier
R-HSA-190239
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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FGFR3 ligand binding and activation
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FGFR3 is a receptor tyrosine kinase of the FGF receptor family, known to have a negative regulatory effect on long bone growth. Somatically, some of the same activating mutations are associated with hypochondroplasia, multiple myeloma, and cervical and vesical carcinoma.
Literature References
PubMed ID Title Journal Year
16597617 Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

Ornitz, DM, Umemori, H, Mohammadi, M, Olsen, SK, Ibrahimi, OA, Zhang, X

J Biol Chem 2006
15748888 Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

L'Hote, CG, Knowles, MA

Exp Cell Res 2005
9045692 Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.

Podolsky, DK, Goke, M, Tsunekawa, S, Kanai, M

J Biol Chem 1997
Participants
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Event Information
Go Biological Process
fibroblast growth factor receptor signaling pathway (0008543)
Orthologous Events
FGFR3 ligand binding and activation (Bos taurus)
FGFR3 ligand binding and activation (Caenorhabditis elegans)
FGFR3 ligand binding and activation (Canis familiaris)
FGFR3 ligand binding and activation (Danio rerio)
FGFR3 ligand binding and activation (Drosophila melanogaster)
FGFR3 ligand binding and activation (Gallus gallus)
FGFR3 ligand binding and activation (Mus musculus)
FGFR3 ligand binding and activation (Rattus norvegicus)
FGFR3 ligand binding and activation (Sus scrofa)
FGFR3 ligand binding and activation (Xenopus tropicalis)
Authored
de Bono, B  (2007-01-10)
Reviewed
Mohammadi, M  (2007-02-07)
Created
de Bono, B  (2006-12-18)
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