Reactome | FGFR3b binds to FGF

FGFR3b binds to FGF

Stable Identifier

R-HSA-190263

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR3 (Homo sapiens)
      - FGFR3 ligand binding and activation (Homo sapiens)
        
        FGFR3b ligand binding and activation (Homo sapiens)
        
        FGFR3b binds to FGF (Homo sapiens)

General

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In this reaction, FGF receptor in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate.

Literature References

PubMed ID	Title	Journal	Year
15863029	Structural basis for fibroblast growth factor receptor activation Olsen, SK, Mohammadi, M, Ibrahimi, OA	Cytokine Growth Factor Rev	2005
16597617	Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. Ornitz, DM, Umemori, H, Mohammadi, M, Olsen, SK, Ibrahimi, OA, Zhang, X	J Biol Chem	2006