Reactome | p-5Y-FGFR4 [plasma membrane]

p-5Y-FGFR4 [plasma membrane]

Stable Identifier

R-HSA-190330

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

phosphorylated FGFR4, Phosphorylated Fibroblast growth factor receptor 4, FGR4_HUMAN, FGFR4

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
        
        p-5Y-FGFR4 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
        
        p-5Y-FGFR4 [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
        
        p-5Y-FGFR4 [plasma membrane] (Homo sapiens)
        
        Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
        
        p-5Y-FGFR4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P22455 FGFR4

Gene Names

FGFR4, JTK2, TKF

Chain

signal peptide:1-21, chain:22-802

Reference Genes

BioGPS Gene:2264 FGFR4

COSMIC (genes):FGFR4 FGFR4

CTD Gene:2264 FGFR4

dbSNP Gene:2264 FGFR4

ENSEMBL:ENSG00000160867 FGFR4

HGNC:3691 FGFR4

KEGG:hsa:2264 FGFR4

Monarch:2264 FGFR4

NCBI Gene:2264 FGFR4

OMIM:134935 FGFR4

UCSC:P22455 FGFR4

Reference Transcript

Other Identifiers

11735873_a_at

11740240_a_at

11744657_x_at

11752172_a_at

11753528_a_at

11757181_x_at

11762799_a_at

1291_s_at

1554961_PM_at

1554961_at

1554962_PM_a_at

1554962_a_at

16992957

204579_PM_at

204579_at

211237_PM_s_at

211237_s_at

2264

2842910

2842912

2842913

2842914

2842915

2842916

2842918

2842919

2842920

2842921

2842922

2842923

2842924

2842925

2842926

2842928

2842929

2842930

2842931

2842932

2842933

2842934

2842935

2842936

2842937

2842938

2842939

2842940

2842941

2842943

2842944

8110265

A_14_P131381

A_14_P138290

A_23_P92754

GE57553

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005007

GO:0005515

GO:0005524

GO:0005576

GO:0005737

GO:0005768

GO:0005783

GO:0005794

GO:0005886

GO:0005911

GO:0006468

GO:0008201

GO:0008284

GO:0008543

GO:0010628

GO:0010715

GO:0016020

GO:0016477

GO:0016740

GO:0017134

GO:0018108

GO:0019216

GO:0030133

GO:0031410

GO:0042593

GO:0042632

GO:0043085

GO:0043226

GO:0043235

GO:0045862

GO:0046777

GO:0048870

GO:0055062

GO:0060089

GO:0070374

GO:0070857

GO:0140096

GO:2000573

HMNXSV003054104

Hs2.165950.4.S1_3p_at

ILMN_1730355

ILMN_2241412

ILMN_2410713

L03840_s_at

PH_hs_0010000

TC05001010.hg

g13112051_3p_at

g6739817_3p_a_at

Participates

as a component of

Other forms of this molecule

FGFR4 [plasma membrane]

p5Y-FGFR4 Y367C mutant [plasma membrane]

p-5Y-FGFR4 N535D [plasma membrane]

p-5Y-FGFR4 V550L [plasma membrane]

p-5Y-FGFR4 N535K [plasma membrane]

p-5Y-FGFR4 V550E [plasma membrane]

FGFR4 N535D [plasma membrane]

FGFR4 V550L [plasma membrane]

FGFR4 V550E [plasma membrane]

FGFR4 N535K [plasma membrane]

FGFR4 Y367C [plasma membrane]

Inferred To

Homologues of p-5Y-FGFR4 [plasma membrane] (Drosophila melanogaster)

phospho-p-5Y-FGFR4 [plasma membrane] (Bos taurus)

phospho-p-5Y-FGFR4 [plasma membrane] (Caenorhabditis elegans)

phospho-p-5Y-FGFR4 [plasma membrane] (Canis familiaris)

phospho-p-5Y-FGFR4 [plasma membrane] (Danio rerio)

phospho-p-5Y-FGFR4 [plasma membrane] (Drosophila melanogaster)

phospho-p-5Y-FGFR4 [plasma membrane] (Gallus gallus)

phospho-p-5Y-FGFR4 [plasma membrane] (Mus musculus)

phospho-p-5Y-FGFR4 [plasma membrane] (Rattus norvegicus)

phospho-p-5Y-FGFR4 [plasma membrane] (Sus scrofa)

phospho-p-5Y-FGFR4 [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 643

Coordinate

643

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 642

Coordinate

642

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 719

Coordinate

719

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 754

Coordinate

754

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 764

Coordinate

764

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002002.3, NP_998812.1, XP_005265895.1, NP_001278909.1, NP_075252.2

ZINC - World Drugs

FGFR4_HUMAN

Guide to Pharmacology - Targets

1811

OpenTargets

ENSG00000160867

ENSEMBL

ENSP00000377254, ENST00000502906, ENST00000393637, ENSP00000292408, ENST00000292408, ENSP00000424960

ZINC - FDA approved

FGFR4_HUMAN

ZINC - Substances

FGFR4_HUMAN

ZINC - Biogenic

FGFR4_HUMAN

ZINC target

P22455

PRO

P22455

PDB

4TYJ, 7DTZ, 7N1J, 7F3M, 4QQ5, 4TYI, 4TYG, 7WCW, 7YC1, 7YC3, 5JKG, 4QQT, 7VJL, 6IUP, 6NVH, 7TYD, 4R6V, 4QQC, 7YBP, 6NVI, 4QQJ, 4TYE, 6JPE, 6IUO, 6YI8, 7WCT, 8XLQ, 6NVG, 7YSW, 5NUD, 6NVK, 6NVJ, 4XCU, 5XFJ, 7V29, 5NWZ, 5XFF, 6V9C, 6J6Y, 4UXQ, 7WCX, 7YBX, 6JPJ, 4QRC, 7YBO

ZINC - Investigational

FGFR4_HUMAN

HPA

ENSG00000160867-FGFR4

Pharos - Targets

P22455

ZINC - Predictions - Purchasable

FGFR4_HUMAN

HMDB Protein

HMDBP01234

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11362 FGFR1	9	FGFR1 [plasma membrane] (R-HSA-9756433) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) FGFR1 R576W [plasma membrane] (R-HSA-2011844) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241)	0.539	3
UniProt:Q6ZMH5 SLC39A5	1	SLC39A5 [plasma membrane] (R-HSA-442360)	0.527	2
UniProt:P55899 FCGRN			0.527	2
UniProt:Q96G30 MRAP2			0.527	2
UniProt:Q3MIR4 CC50B			0.527	2
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.519	2
UniProt:P07949 RET	2	RET [plasma membrane] (R-HSA-8853797) p-5Y-RET [plasma membrane] (R-HSA-8854162)	0.499	2
UniProt:P05230 FGF1	1	FGF1 [extracellular region] (R-HSA-189856)	0.483	2

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