Reactome | GJC1 [endoplasmic reticulum membrane]

GJC1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-190716

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Connexin 45

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Gap junction trafficking and regulation (Homo sapiens)
    - Gap junction trafficking (Homo sapiens)
      - Gap junction assembly (Homo sapiens)
        
        Connexin synthesis (generic) (Homo sapiens)
        
        Monomeric connexin protein [endoplasmic reticulum membrane] (Homo sapiens)
        
        GJC1 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P36383 GJC1

Gene Names

GJC1, GJA7

Chain

chain:1-396

Reference Genes

BioGPS Gene:10052 GJC1

COSMIC (genes):GJC1 GJC1

CTD Gene:10052 GJC1

dbSNP Gene:10052 GJC1

ENSEMBL:ENSG00000182963 GJC1

ENSEMBL_homo_sapiens_GENE:ENSG00000182963.11 GJC1

HGNC:4280 GJC1

KEGG Gene (Homo sapiens):10052 GJC1

Monarch:10052 GJC1

NCBI Gene:10052 GJC1

OMIM:608655 GJC1

UCSC:P36383 GJC1

Reference Transcript

Other Identifiers

10052

11740256_s_at

11753126_s_at

11754438_x_at

16845736

208460_PM_at

208460_at

228563_PM_at

228563_at

228776_PM_at

228776_at

231048_PM_at

231048_at

243502_PM_at

243502_at

33041_at

3759332

3759334

3759336

3759337

3759338

3759339

3759340

3759341

3759342

3759343

3759344

3759345

3759346

3759348

3759349

3759351

41927_at

45229_at

59139_at

8016094

81220_at

87504_at

A_23_P428287

A_32_P702236

A_33_P3373358

GE62949

GE85625

GO:0001570

GO:0003012

GO:0003013

GO:0005215

GO:0005216

GO:0005243

GO:0005515

GO:0005634

GO:0005654

GO:0005783

GO:0005789

GO:0005886

GO:0005921

GO:0005922

GO:0006936

GO:0007043

GO:0007154

GO:0007267

GO:0007268

GO:0007507

GO:0007601

GO:0014704

GO:0016020

GO:0016264

GO:0023052

GO:0030154

GO:0034220

GO:0034330

GO:0043226

GO:0045202

GO:0048468

GO:0048738

GO:0048856

GO:0050877

GO:0055085

GO:0070161

GO:0086014

GO:0086020

GO:0086021

GO:0086053

GO:0086077

HMNXSV003006828

Hs.193480.0.A1_3p_at

Hs.245330.0.A1_3p_at

Hs.43761.0.A1_3p_at

Hs.43761.1.A1_3p_at

ILMN_1687023

ILMN_2397484

PH_hs_0011414

PH_hs_0026533

TC17001585.hg

g4885168_3p_at

p6853

Participates

as a member of

Monomeric connexin protein [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

GJC1 [plasma membrane]

Inferred To

Gjc1 [endoplasmic reticulum membrane] (Mus musculus)

Gjc1 [endoplasmic reticulum membrane] (Rattus norvegicus)

GJC1 [endoplasmic reticulum membrane] (Bos taurus)

GJC1 [endoplasmic reticulum membrane] (Canis familiaris)

GJC1 [endoplasmic reticulum membrane] (Gallus gallus)

GJC1 [endoplasmic reticulum membrane] (Sus scrofa)

gjc1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_005256978.1, NP_005488.2, XP_005256977.1, NP_001073852.1

Guide to Pharmacology - Targets

729

OpenTargets

ENSG00000182963

GeneCards

P36383

HPA

ENSG00000182963-GJC1

Ensembl

ENSP00000466339, ENSP00000333193, ENSG00000182963, ENST00000330514, ENSP00000467201, ENST00000592524, ENST00000590758

PRO

P36383

Pharos - Targets

P36383

Orphanet

25380

PDB

3SHW

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43119 PTGIR	1	PTGIR [plasma membrane] (R-HSA-391834)	0.527	2